The design and synthesis of potent cyclic peptide VCAM-VLA-4 antagonists incorporating an achiral Asp-Pro mimetic

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 11, 2000, Pages 1171-1173

  Fotouhi, Nader ^a   Joshi, Pramod ^a   Fry, David ^a   Cook, Charles ^a   Tilley, Jefferson W ^a   Kaplan, Gerry ^a   Hanglow, Angela ^a   Rowan, Karen ^a   Schwinge, Virginia ^a   Wolitzky, Barry ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; CARBOXYLIC ACID DERIVATIVE; CYCLIC NUCLEOTIDE; PROTEIN INHIBITOR; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION;

ASPARTIC ACID; DRUG DESIGN; INTEGRIN ALPHA4BETA1; INTEGRINS; MOLECULAR MIMICRY; PEPTIDES, CYCLIC; PROLINE; RECEPTORS, LYMPHOCYTE HOMING; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0034608629     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00174-8     Document Type: Article

References (7)

1. Elices, M. In Cell Adhesion Molecules and Matrix Proteins: Role in Health and Diseases: Mousa, S. A., Ed.; Springer-Verlag: 1998; pp 133-147.
2. Lin, K.-c.; Ateeq, H. S.; Hsiung, S. H.; Chong, L. T.; Zimmerman, C. N.; Castro, A.; Lee, W.-c.; Hammond, C. E.; Kalkunte, S.; Chen, L.-L.; Pepinsky, R. B.; Leone, D. R.; Sprague, A. G.; Abraham, W. M.; Gill, A.; Lobb, R. A.; Adams, S. P. J. Med. Chem. 1999, 42, 920. Lin, K.-C., Castro, A. C. Curr. Opin. Chem. Biol. 1998, 2, 453.
3. Lin, K.-c.; Ateeq, H. S.; Hsiung, S. H.; Chong, L. T.; Zimmerman, C. N.; Castro, A.; Lee, W.-c.; Hammond, C. E.; Kalkunte, S.; Chen, L.-L.; Pepinsky, R. B.; Leone, D. R.; Sprague, A. G.; Abraham, W. M.; Gill, A.; Lobb, R. A.; Adams, S. P. J. Med. Chem. 1999, 42, 920. Lin, K.-C., Castro, A. C. Curr. Opin. Chem. Biol. 1998, 2, 453.
4. Elices M. Curr. Opin. in Antiinflammat. and Immunomodulat. Investigat. Drugs. 1:1999;14.
5. Jackson D., Quan C., Artis D.R., Rawson T., Blackburn B., Struble M., Fitzgerald G., Chan K., Mullins S., Burnier J.P., Fairbrother W.J., Clark K., Berisini M., Chui H., Renz M., Jones S., Fong S. J. Med. Chem. 40:1997;3359.
6. Lobl, T. J.; Chiang, S.-L.; Cardarelli, P. M. WO 9200995, 1992.
7. Chen, I.; Guthrie, R.; Huang, T.-N.; Hull, K.; Sidduri, A.; Tilley, J. W. WO 9910312, 1999.