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Volumn 6, Issue 3, 2005, Pages 186-193

Determination of gene organization in the human IGHV region on single chromosomes

Author keywords

Deletion insertion polymorphism; IGHV; Microarray; Multiplex PCR; Single sperm

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

EID: 18444394036     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6364176     Document Type: Article
Times cited : (28)

References (50)
  • 1
    • 0003472822 scopus 로고
    • Chromosomal location of the genes for human immunoglobulin heavy chains
    • Croce CM, Shander M, Martinis J et al. Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci USA 1979; 76: 3416-3419.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 3416-3419
    • Croce, C.M.1    Shander, M.2    Martinis, J.3
  • 2
    • 0020327819 scopus 로고
    • Genes for immunoglobulin heavy chains and for alpha 1-antitrypsin are localized to specific regions of chromosome 14q
    • Cox DW, Markovic VD, Teshima IE. Genes for immunoglobulin heavy chains and for alpha 1-antitrypsin are localized to specific regions of chromosome 14q. Nature 1982; 297: 428-430.
    • (1982) Nature , vol.297 , pp. 428-430
    • Cox, D.W.1    Markovic, V.D.2    Teshima, I.E.3
  • 3
    • 0020051390 scopus 로고
    • Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes
    • Kirsch IR, Morton CC, Nakahara K, Leder P. Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes. Science 1982; 216: 301-303.
    • (1982) Science , vol.216 , pp. 301-303
    • Kirsch, I.R.1    Morton, C.C.2    Nakahara, K.3    Leder, P.4
  • 4
    • 0025196326 scopus 로고
    • New localizations of VH sequences by in situ hybridization with biotinylated probes
    • Cherif D, Berger R. New localizations of VH sequences by in situ hybridization with biotinylated probes. Genes Chromosomes Cancer 1990; 2: 103-108.
    • (1990) Genes Chromosomes Cancer , vol.2 , pp. 103-108
    • Cherif, D.1    Berger, R.2
  • 5
    • 0025282239 scopus 로고
    • Organization of variable region segments of the human immunoglobulin heavy chain: Duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments
    • Matsuda F, Shin EK, Hirabayashi Y, Nagaoka H. Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments. EMBO J 1990; 9: 2501-2506.
    • (1990) EMBO J. , vol.9 , pp. 2501-2506
    • Matsuda, F.1    Shin, E.K.2    Hirabayashi, Y.3    Nagaoka, H.4
  • 6
    • 0028180225 scopus 로고
    • Human immunoglobulin VH and D segments on chromosomes 15q11.2 and 16p11.2
    • Tomlinson IM, Cook GP, Carter NP et al. Human immunoglobulin VH and D segments on chromosomes 15q11.2 and 16p11.2. Hum Mol Genet 1994; 3: 853-860.
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 853-860
    • Tomlinson, I.M.1    Cook, G.P.2    Carter, N.P.3
  • 7
    • 0026785856 scopus 로고
    • The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops
    • Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol 1992; 227: 776-798.
    • (1992) J. Mol. Biol. , vol.227 , pp. 776-798
    • Tomlinson, I.M.1    Walter, G.2    Marks, J.D.3    Llewelyn, M.B.4    Winter, G.5
  • 8
    • 0028235295 scopus 로고
    • A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q
    • Cook GP, Tomlinson IM, Walter G et al. A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. Nat Genet 1994; 7: 162-168.
    • (1994) Nat. Genet. , vol.7 , pp. 162-168
    • Cook, G.P.1    Tomlinson, I.M.2    Walter, G.3
  • 10
    • 0027475327 scopus 로고
    • Structure and physical map of 64 variable segments in the 3′0.8-megabase region of the human immunoglobulin heavy-chain locus
    • Matsuda F, Shin EK, Nagaoka H et al. Structure and physical map of 64 variable segments in the 3′0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat Genet 1993; 3: 88-94.
    • (1993) Nat. Genet. , vol.3 , pp. 88-94
    • Matsuda, F.1    Shin, E.K.2    Nagaoka, H.3
  • 11
    • 0031775443 scopus 로고    scopus 로고
    • The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus
    • Matsuda F, Ishii K, Bourvagnet Pet al. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus. J Exp Med 1998; 188: 2151-2162.
    • (1998) J. Exp. Med. , vol.188 , pp. 2151-2162
    • Matsuda, F.1    Ishii, K.2    Bourvagnet, P.3
  • 13
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity. Nature 1983; 302: 575-581.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 14
    • 0022271336 scopus 로고
    • Origin of immune diversity: Genetic variation and selection
    • Honjo T, Habu S. Origin of immune diversity: genetic variation and selection. Annu Rev Biochem 1985; 54: 803-830.
    • (1985) Annu. Rev. Biochem. , vol.54 , pp. 803-830
    • Honjo, T.1    Habu, S.2
  • 15
    • 0023821895 scopus 로고
    • The dynamic nature of the antibody repertoire
    • Berek C, Milstein C. The dynamic nature of the antibody repertoire. Immunol Rev 1988; 105: 5-26.
    • (1988) Immunol. Rev. , vol.105 , pp. 5-26
    • Berek, C.1    Milstein, C.2
  • 16
    • 0026060620 scopus 로고
    • Intraclonal generation of antibody mutants in germinal centres
    • Jacob J, Kelsoe G, Rajewsky K, Weiss U. Intraclonal generation of antibody mutants in germinal centres. Nature 1991; 354: 389-392.
    • (1991) Nature , vol.354 , pp. 389-392
    • Jacob, J.1    Kelsoe, G.2    Rajewsky, K.3    Weiss, U.4
  • 17
    • 0037926476 scopus 로고    scopus 로고
    • Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation
    • Pham P, Bransteitter R, Petruska J, Goodman MF. Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature 2003; 424: 103-107.
    • (2003) Nature , vol.424 , pp. 103-107
    • Pham, P.1    Bransteitter, R.2    Petruska, J.3    Goodman, M.F.4
  • 18
    • 0037128169 scopus 로고    scopus 로고
    • Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: Implication of AID involvement in a common step of class switch recombination and somatic hypermutation
    • Nagaoka H, Muramatsu M, Yamamura N, Kinoshita K, Honjo T. Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation. J Exp Med 2002; 195: 529-534.
    • (2002) J. Exp. Med. , vol.195 , pp. 529-534
    • Nagaoka, H.1    Muramatsu, M.2    Yamamura, N.3    Kinoshita, K.4    Honjo, T.5
  • 19
    • 0842303307 scopus 로고    scopus 로고
    • Unraveling V(D)J recombination; insights into gene regulation
    • Jung D, Alt FW. Unraveling V(D)J recombination; insights into gene regulation. Cell 2004; 116: 299-311.
    • (2004) Cell , vol.116 , pp. 299-311
    • Jung, D.1    Alt, F.W.2
  • 20
    • 0033621672 scopus 로고    scopus 로고
    • Human immunoglobulin VH4 sequences resolved by population-based analysis after enzymatic amplification and denaturing gradient gel electrophoresis
    • Cui X, Li H. Human immunoglobulin VH4 sequences resolved by population-based analysis after enzymatic amplification and denaturing gradient gel electrophoresis. Eur J Immunogenet 2000; 27: 37-46.
    • (2000) Eur. J. Immunogenet. , vol.27 , pp. 37-46
    • Cui, X.1    Li, H.2
  • 21
    • 0032167853 scopus 로고    scopus 로고
    • Determination of gene organization in individual haplotypes by analyzing single DNA fragments from single spermatozoa
    • Cui X, Li H. Determination of gene organization in individual haplotypes by analyzing single DNA fragments from single spermatozoa. Proc Natl Acad Sci USA 1998; 95: 10791-10796.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10791-10796
    • Cui, X.1    Li, H.2
  • 22
    • 0030872569 scopus 로고    scopus 로고
    • Discriminating between allelic and interlocus differences among human immunoglobulin VH4 sequences by analyzing single spermatozoa
    • Cui X, Li H. Discriminating between allelic and interlocus differences among human immunoglobulin VH4 sequences by analyzing single spermatozoa. Hum Genet 1997; 100: 96-100.
    • (1997) Hum. Genet. , vol.100 , pp. 96-100
    • Cui, X.1    Li, H.2
  • 23
    • 0036954986 scopus 로고    scopus 로고
    • Genetic diversity of the human immunoglobulin heavy chain VH region
    • Li H, Cui X, Pramanik S, Chimge NO. Genetic diversity of the human immunoglobulin heavy chain VH region. Immunol Rev 2002; 190: 53-68.
    • (2002) Immunol. Rev. , vol.190 , pp. 53-68
    • Li, H.1    Cui, X.2    Pramanik, S.3    Chimge, N.O.4
  • 24
    • 0036908779 scopus 로고    scopus 로고
    • Direct detection of insertion/deletion polymorphisms in an autosomal region by analyzing high-density markers in individual spermatozoa
    • Pramanik S, Li H. Direct detection of insertion/deletion polymorphisms in an autosomal region by analyzing high-density markers in individual spermatozoa. Am J Hum Genet 2002; 71: 1342-1352.
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 1342-1352
    • Pramanik, S.1    Li, H.2
  • 26
    • 0028922293 scopus 로고
    • Multiplex genotype determination at a DNA sequence polymorphism cluster in the human immunoglobulin heavy-chain region
    • Li H, Hood L. Multiplex genotype determination at a DNA sequence polymorphism cluster in the human immunoglobulin heavy-chain region. Genomics 1995; 26: 199-206.
    • (1995) Genomics , vol.26 , pp. 199-206
    • Li, H.1    Hood, L.2
  • 27
    • 0034908554 scopus 로고    scopus 로고
    • Nomenclature for the description of human sequence variations
    • den Dunnen JT, Antonarakis SE. Nomenclature for the description of human sequence variations. Hum Genet 2001; 109: 121-124.
    • (2001) Hum. Genet. , vol.109 , pp. 121-124
    • den Dunnen, J.T.1    Antonarakis, S.E.2
  • 28
    • 0025940703 scopus 로고
    • Physical map of the 3′ region of the human immunoglobulin heavy chain locus: Clustering of autoantibody-related variable segments in one haplotype
    • Shin EK, Matsuda F, Nagaoka H et al. Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype. EMBO J 1991; 10: 3641-3645.
    • (1991) EMBO J. , vol.10 , pp. 3641-3645
    • Shin, E.K.1    Matsuda, F.2    Nagaoka, H.3
  • 29
    • 0025318399 scopus 로고
    • A segment of human Vh gene locus is duplicated
    • Chen PP, Yang PM. A segment of human Vh gene locus is duplicated. Scand J Immunol 1990; 31: 593-599.
    • (1990) Scand. J. Immunol. , vol.31 , pp. 593-599
    • Chen, P.P.1    Yang, P.M.2
  • 30
    • 0025186353 scopus 로고
    • Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases
    • Yang PM, Olsen NJ, Siminovitch KA et al. Possible deletion of a developmentally regulated heavy-chain variable region gene in autoimmune diseases. Proc Natl Acad Sci USA 1990; 87: 7907-7911.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7907-7911
    • Yang, P.M.1    Olsen, N.J.2    Siminovitch, K.A.3
  • 34
    • 0025850625 scopus 로고
    • A deletion map of the human immunoglobulin heavy chain variable region
    • Walter MA, Dosch HM, Cox DW. A deletion map of the human immunoglobulin heavy chain variable region. J Exp Med 1991; 174: 335-349.
    • (1991) J. Exp. Med. , vol.174 , pp. 335-349
    • Walter, M.A.1    Dosch, H.M.2    Cox, D.W.3
  • 35
  • 36
    • 0020636838 scopus 로고
    • Variable amplification of immunoglobulin lambda light-chain genes in human populations
    • Taub RA, Hollis GF, Hieter PA, Korsmeyer S, Waldmann TA, Leder P. Variable amplification of immunoglobulin lambda light-chain genes in human populations. Nature 1983; 304: 172-174.
    • (1983) Nature , vol.304 , pp. 172-174
    • Taub, R.A.1    Hollis, G.F.2    Hieter, P.A.3    Korsmeyer, S.4    Waldmann, T.A.5    Leder, P.6
  • 37
    • 0027231544 scopus 로고
    • The immunoglobulin kappa locus: Polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals
    • Schaible G, Rappold GA, Pargent W, Zachau HG. The immunoglobulin kappa locus: polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals. Hum Genet 1993; 91: 261-267.
    • (1993) Hum. Genet. , vol.91 , pp. 261-267
    • Schaible, G.1    Rappold, G.A.2    Pargent, W.3    Zachau, H.G.4
  • 38
    • 0024464684 scopus 로고
    • Deletion, insertion, and restriction site polymorphism of the T-cell receptor gamma variable locus in French, Lebanese, Tunisian, and black African populations
    • Ghanem N, Buresi C, Moisan JP et al. Deletion, insertion, and restriction site polymorphism of the T-cell receptor gamma variable locus in French, Lebanese, Tunisian, and black African populations. Immunogenetics 1989; 30: 350-360.
    • (1989) Immunogenetics , vol.30 , pp. 350-360
    • Ghanem, N.1    Buresi, C.2    Moisan, J.P.3
  • 39
    • 0025730535 scopus 로고
    • Polymorphism of the T-cell receptor gamma variable and constant region genes in a Chinese population
    • Ghanem N, Soua Z, Zhang XG et al. Polymorphism of the T-cell receptor gamma variable and constant region genes in a Chinese population. Hum Genet 1991; 86: 450-456.
    • (1991) Hum. Genet. , vol.86 , pp. 450-456
    • Ghanem, N.1    Soua, Z.2    Zhang, X.G.3
  • 40
    • 0022340433 scopus 로고
    • HLA-DR beta genes vary in number between different DR specificities, whereas the number of DQ beta genes is constant
    • Bohme J, Andersson M, Andersson G, Moller E, Peterson PA, Rask L. HLA-DR beta genes vary in number between different DR specificities, whereas the number of DQ beta genes is constant. J Immunol 1985; 135: 2149-2155.
    • (1985) J. Immunol. , vol.135 , pp. 2149-2155
    • Bohme, J.1    Andersson, M.2    Andersson, G.3    Moller, E.4    Peterson, P.A.5    Rask, L.6
  • 41
    • 0023764110 scopus 로고
    • Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis
    • Tokunaga K, Saueracker G, Kay PH, Christiansen FT, Anand R, Dawkins RL. Extensive deletions and insertions in different MHC supratypes detected by pusled field gel electrophoresis. J Exp Med 1988; 168: 933-940.
    • (1988) J. Exp. Med. , vol.168 , pp. 933-940
    • Tokunaga, K.1    Saueracker, G.2    Kay, P.H.3    Christiansen, F.T.4    Anand, R.5    Dawkins, R.L.6
  • 43
    • 0347572662 scopus 로고    scopus 로고
    • Variations of human killer cell lectin-like receptors: Common occurrence of NKG2-C deletion in the general population
    • Hikami K, Tsuchiya N, Yabe T, Tokunaga K. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. Genes Immun 2003; 4: 160-167.
    • (2003) Genes Immun. , vol.4 , pp. 160-167
    • Hikami, K.1    Tsuchiya, N.2    Yabe, T.3    Tokunaga, K.4
  • 44
    • 0020454947 scopus 로고
    • Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals
    • Lefranc MP, Lefranc G, Rabbitts TH. Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals. Nature 1982; 300: 760-762.
    • (1982) Nature , vol.300 , pp. 760-762
    • Lefranc, M.P.1    Lefranc, G.2    Rabbitts, T.H.3
  • 45
    • 0021207635 scopus 로고
    • Multiple gene deletions within the human immunoglobulin heavy-chain cluster
    • Migone N, Oliviero S, de Lange G et al. Multiple gene deletions within the human immunoglobulin heavy-chain cluster. Proc Natl Acad Sci USA 1984; 81: 5811-5815.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 5811-5815
    • Migone, N.1    Oliviero, S.2    de Lange, G.3
  • 46
    • 0030792902 scopus 로고    scopus 로고
    • The G4 gene is duplicated in 44% of human immunoglobulin heavy chain constant region haplotypes
    • Brusco A, Cinque F, Saviozzi S, Boccazzi C, De Marchi M, Carbonara AO. The G4 gene is duplicated in 44% of human immunoglobulin heavy chain constant region haplotypes. Hum Genet 1997; 100: 84-89.
    • (1997) Hum. Genet. , vol.100 , pp. 84-89
    • Brusco, A.1    Cinque, F.2    Saviozzi, S.3    Boccazzi, C.4    De Marchi, M.5    Carbonara, A.O.6
  • 47
    • 0028964024 scopus 로고
    • Variability of the immunoglobulin heavy chain constant region locus: A population study
    • Brusco A, Cariota U, Bottaro A et al. Variability of the immunoglobulin heavy chain constant region locus: a population study. Hum Genet 1995; 95: 319-326.
    • (1995) Hum. Genet. , vol.95 , pp. 319-326
    • Brusco, A.1    Cariota, U.2    Bottaro, A.3
  • 48
    • 0022614074 scopus 로고
    • Duplication of the human immunoglobulin heavy chain gamma 2 gene
    • Bech-Hansen NT, Cox DW. Duplication of the human immunoglobulin heavy chain gamma 2 gene. Am J Hum Genet 1986; 38: 67-74.
    • (1986) Am. J. Hum. Genet. , vol.38 , pp. 67-74
    • Bech-Hansen, N.T.1    Cox, D.W.2
  • 49
    • 0027368968 scopus 로고
    • Novel human immunoglobulin heavy chain constant region gene deletion haplotypes characterized by pulsed-field electrophoresis
    • Olsson PG, Rabbani H, Hammarstrom L, Smith CI. Novel human immunoglobulin heavy chain constant region gene deletion haplotypes characterized by pulsed-field electrophoresis. Clin Exp Immunol 1993; 94: 84-90.
    • (1993) Clin. Exp. Immunol. , vol.94 , pp. 84-90
    • Olsson, P.G.1    Rabbani, H.2    Hammarstrom, L.3    Smith, C.I.4
  • 50
    • 0024399081 scopus 로고
    • Single-sperm typing: Determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers
    • Cui XF, Li HH, Goradia TM et al. Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers. Proc Natl Acad Sci USA 1989; 86: 9389-9393.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9389-9393
    • Cui, X.F.1    Li, H.H.2    Goradia, T.M.3


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