The role of RANKL (TRANCE/TNFSF11), a tumor necrosis factor family member, in skeletal development: Effects of gene knockout and transgenic rescue

Connective Tissue Research

Volumn 44, Issue SUPPL. 1, 2003, Pages 264-271

  Odgren, Paul R ^a   Kim, Nacksung ^b   MacKay, Carole A ^a   Mason Savas, April ^a   Choi, Yongwon ^b   Marks Jr , Sandy C ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Chondrodysplasia; Osteoclast; Osteopetrosis; Tooth eruption

Indexed keywords

ACID PHOSPHATASE; GROWTH PROMOTOR; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR;

ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BONE DEVELOPMENT; BONE GROWTH; CELLULAR IMMUNITY; CHONDRODYSPLASIA; CONTROLLED STUDY; DIAPHYSIS; DISEASE SEVERITY; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GROWTH PLATE; GROWTH RETARDATION; IMMUNOPATHOLOGY; JAW; LAMELLAR BODY; LIMB; LONG BONE; LYMPH NODE; MOUSE; NONHUMAN; ORGANOGENESIS; OSTEOCLAST; OSTEOPENIA; OSTEOPOROSIS; OSTEOSCLEROSIS; PERIOSTEUM; PUERPERIUM; T LYMPHOCYTE; TOOTH DISEASE; TOOTH ERUPTION; TRANSGENE;

ANIMALIA; MAMMALIA;

EID: 12244307844     PISSN: 03008207     EISSN: None     Source Type: Journal    
DOI: 10.1080/03008200390181753     Document Type: Article

References (26)

1. Anderson, D.M., Maraskovsky, E., Billingsley, W.L., Dougall, W.C., Tometsko, M.E., Roux, E.R., Teepe, M.C., DuBose, R.F., Cosman, D., and Galibert, L. (1997). A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390:175-179.
2. ASBMR President's Committee on Nomenclature. (2000). Proposed standard nomenclature for new tumor necrosis factor family members involved in the regulation of bone resorption. J. Bone Min. Res. 15:2293-2296.
3. Collin-Osdoby, P., Rothe, L., Anderson, F., Nelson, M., Maloney, W., and Osdoby, P. (2001). Receptor activator of NF-kappa B and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesis. J. Biol. Chem. 276:20659-20672.
4. Eggli, P.S., Herrmann, W., Hunziker, E.B., and Schenk, R.K. (1985). Matrix compartments in the growth plate of the proximal tibia of rats. Anat. Rec. 211:246-257.
5. Ek-Rylander, B., Marks, S.C., Jr., Hammarstrom, L.E., and Andersson, G.N. (1989). Osteoclastic acid ATPase: Biochemical and histochemical studies of the osteopetrotic mutations in the rat. Bone Miner. 5:309-321.
6. Hofbauer, L.C., Khosla, S., Dunstan, C.R., Lacey, D.L., Boyle, W.J., and Riggs, B.L. (2000). The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J. Bone Miner. Res. 15:2-12.
7. Hunziker, E.B., Herrmann, W., and Schenk, R.K. (1982). Improved cartilage fixation by ruthenium hexammine trichloride (RHT). A prerequisite for morphometry in growth cartilage. J. Ultrastruct. Res. 81:1-12.
8. Idriss, H.T., and Naismith, J.H. (2000). TNF alpha and the TNF receptor superfamily: Structure-function relationship(s). Microsc. Res. Tech. 50:184-195.
9. Kim, D., Mebius, R.E., MacMicking, J.D., Jung, S., Cupedo, T., Castellanos, Y., Rho, J., Wong, B.R., Josien, R., Kim, N., Rennert, P.D., and Choi, Y. (2000a). Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCE. J. Exp. Med. 192:1467-1478.
10. Kim, N., Odgren, P.R., Kim, D.K., Marks, S.C., Jr., and Choi, Y. (2000b). Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene. Proc. Natl. Acad. Sci. USA 97:10905-10910.
11. Kong, Y.Y., Boyle, W.J., and Penninger, J.M. (1999a). Osteoprotegerin ligand: A common link between osteoclastogenesis, lymph node formation and lymphocyte development. Immunol. Cell Biol. 77:188-193.
12. Kong, Y.Y., Yoshida, H., Sarosi, I., Tan, H.L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A.J., Van, G., Itie, A., Khoo, W., Wakeham, A., Dunstan, C.R., Lacey, D.L., Mak, T.W., Boyle, W. J., and Penninger, J.M. (1999b). OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315-323.
13. Lacey, D.L., Timms, E., Tan, H.L., Kelley, M.J., Dunstan, C.R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y.X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J., and Boyle, W.J. (1998). Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176.
14. Lee, E.R., Lamplugh, L., Shepard, N.L., and Mort, J.S. (1995). The septoclast, a cathepsin B-rich cell involved in the resorption of growth plate cartilage. J. Histochem. Cytochem. 43:525-536.
15. Locksley, R.M., Killeen, N., and Lenardo, M.J. (2001). The TNF and TNF receptor superfamilies: Integrating mammalian biology. Cell 104:487-501.
16. Marks, S.C., Jr., Cielinski, M.J., Sundquist, K., Wise, G.E., and Gorski, J.P. (1994). The role of bone resorption in tooth eruption. In Proceedings of the International Conference on Biological Mechanisms of Tooth Eruption, Resorption and Replacement by Implants, Z. Davidovitch (ed.), pp. 483-488. (Birmingham, AL: EBSCO Press).
17. Min, H., Morony, S., Sarosi, I., Dunstan, C.R., Capparelli, C., Scully, S., Van, G., Kaufman, S., Kostenuik, P.J., Lacey, D.L., Boyle, W.J., and Simonet, W.S. (2000). Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis. J. Exp. Med. 192:463-474.
18. Odgren, P.R., Kim, N., Van Wesenbeeck, L., MacKay, C.A., Mason-Savas, A., Safadi, F.F., Popoff, S. N., Lengner, C., Van Hul, W., Choi, Y., and Marks, S.C.J. (2001). Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene. Int. J. Dev. Biol. 45:853-859.
19. Odgren, P.R., Popoff, S.N., Safadi, F.F., MacKay, C.A., Mason-Savas, A., Seifert, M.F., and Marks, S.C., Jr. (1999). The toothless osteopetrotic rat has a normal vitamin D-binding protein-macrophage activating factor (DBP-MAF) cascade and chondrodysplasia resistant to treatments with colony stimulating factor-1 (CSF-1) and/or DBP-MAF. Bone 25:175-181.
20. Seifert, M.F. (1996). Abnormalities in bone cell function and endochondral ossification in the osteopetrotic toothless rat. Bone. 19:329-338.
21. Simonet, W.S., Lacey, D.L., Dunstan, C.R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., Shimamoto, G., DeRose, M., Elliott, R., Colombero, A., Tan, H.-L., Trail, G., Sullivan, J., Davy, E., Bucay, N., Renshaw-Gegg, L., Hughes, T.M., Hill, D., Pattison, W., Campbell, P., Sander, S., Van, G., Tarpley, J., Derby, P., Lee, R., and Boyle, W.J. (1997). Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89:309-319.
22. Sundquist, K.T., and Marks, S.C., Jr. (1994). Bafilomycin A1 inhibits bone resorption and tooth eruption in vivo. J. Bone. Miner. Res. 9:1575-1582.
23. Takahashi, N., Udagawa, N., and Suda, T. (1999). A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function. Biochem. Biophys. Res. Comm. 256:449-455.
24. Wong, B.R., Josien, R., Lee, S.Y., Sauter, B., Li, H. L., Steinman, R.M., and Choi, Y. (1997a). TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J. Exp. Med. 186:2075-2080.
25. Wong, B.R., Rho, J., Arron, J., Robinson, E., Orlinick, J., Chao, M., Kalachikov, S., Cayani, E., Bartlett, F.S., 3rd, Frankel, W.N., Lee, S.Y., and Choi, Y. (1997b). TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J. Biol. Chem. 272:25190-25194.
26. Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., Tsuda, E., Morinaga, T., Higashio, K., Udagawa, N., Takahashi, N., and Suda, T. (1998). Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc. Natl. Acad. Sci. USA 95:3597-3602.