N-(arylacetyl)-biphenylalanines as potent VLA-4 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 16, 2002, Pages 2141-2144

  Li, Bing ^a   De Laszlo, Stephen E ^a   Kamenecka, Theodore M ^a   Kopka, Ihor E ^a   Durette, Philippe L ^a   Lanza, Jr, Thomas ^a   MacCoss, Malcolm ^a   Tong, Sharon ^a   Mumford, Richard A ^a   McCauley, Ermengilda D ^a   Van Riper, Gail ^a   Schmidt, John A ^a   Hagmann, William K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4 ANTAGONIST; DRUG DERIVATIVE; PHENYLALANINE; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL EXPERIMENT; ARTICLE; CHEMISTRY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; NONHUMAN; RAT; SAPONIFICATION; SOLID; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; DRUG ANTAGONISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BINDING SITES; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHA4BETA1; MOLECULAR STRUCTURE; PHENYLALANINE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18444363322     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00366-9     Document Type: Article

References (16)