-
1
-
-
0035370483
-
Regulation and function of the p53 tumor suppressor protein
-
DOI 10.1016/S0955-0674(00)00216-7
-
Ryan KM, Phillips AC, Vousden KH. Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol 2001; 13:332-37. (Pubitemid 32429498)
-
(2001)
Current Opinion in Cell Biology
, vol.13
, Issue.3
, pp. 332-337
-
-
Ryan, K.M.1
Phillips, A.C.2
Vousden, K.H.3
-
4
-
-
0033552613
-
Regulation of p53 stability
-
Ashcroft M, Vousden KH. Regulation of p53 stability. Oncogene 1999; 18:7637-43. (Pubitemid 30052690)
-
(1999)
Oncogene
, vol.18
, Issue.53
, pp. 7637-7643
-
-
Ashcroft, M.1
Vousden, K.H.2
-
5
-
-
0034818446
-
Post-translational modifications and activation of p53 by genotoxic stresses
-
DOI 10.1046/j.1432-1327.2001.02225.x
-
Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 2001; 268:2764-72. (Pubitemid 32862957)
-
(2001)
European Journal of Biochemistry
, vol.268
, Issue.10
, pp. 2764-2772
-
-
Appella, E.1
Anderson, C.W.2
-
6
-
-
0033552640
-
Mechanisms of switching on p53: A role for covalent modification?
-
Meek DW. Mechanisms of switching on p53: a role for covalent modification ? Oncogene 1999; 18:7666-75.
-
(1999)
Oncogene
, vol.18
, pp. 7666-7675
-
-
Meek, D.W.1
-
7
-
-
0037127284
-
Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2
-
DOI 10.1074/jbc.M108881200
-
Bean LJH, Stark GR. Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binding Mdm2. J Biol Chem 2002; 277:1864-71. (Pubitemid 34968760)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.3
, pp. 1864-1871
-
-
Bean, L.J.H.1
Stark, G.R.2
-
8
-
-
0033598754
-
Phosphorylation of serine 20 mediates stabilisation of human p53 in response to DNA damage
-
Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD. Phosphorylation of serine 20 mediates stabilisation of human p53 in response to DNA damage. Proc Natl Acad Sci USA 1999; 96:13777-13782.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13777-13782
-
-
Chehab, N.H.1
Malikzay, A.2
Stavridi, E.S.3
Halazonetis, T.D.4
-
9
-
-
0033567340
-
18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers
-
DOI 10.1042/0264-6021:3420133
-
Craig AL, Burch L, Vojtesek B, Mitukovska J, Thompson A, Hupp, TR. Novel phosphorylation sites of human tumour suppressor protein p53 at ser20 and thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers. Biochem J 1999; 342:133-41. (Pubitemid 29410859)
-
(1999)
Biochemical Journal
, vol.342
, Issue.1
, pp. 133-141
-
-
Craig, A.L.1
Burch, L.2
Vojtesek, B.3
Mikutowska, J.4
Thompson, A.5
Hupp, T.R.6
-
10
-
-
0033429271
-
Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15
-
DOI 10.1016/S0014-5793(99)01647-6, PII S0014579399016476
-
Dumaz N, Milne DM, Meek DW. Protein kinase CK1 is a p53 threonine-18 protein kinase which requires prior phosphorylation of serine 15. FEBS Lett 1999; 463:312-16. (Pubitemid 30001941)
-
(1999)
FEBS Letters
, vol.463
, Issue.3
, pp. 312-316
-
-
Dumaz, N.1
Milne, D.M.2
Meek, D.W.3
-
11
-
-
0035887213
-
Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover
-
DOI 10.1042/0264-6021:3590459
-
Dumaz N, Milne DM, Jardine LJ, Meek DW. Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover. Biochem J 2001; 359:459-64. (Pubitemid 32999793)
-
(2001)
Biochemical Journal
, vol.359
, Issue.2
, pp. 459-464
-
-
Dumaz, N.1
Milne, D.M.2
Jardine, L.J.3
Meek, D.W.4
-
12
-
-
0034737438
-
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on MDM2 binding
-
DOI 10.1074/jbc.275.13.9278
-
Sakaguchi K, Saito S, Higashimoto Y, Roy S, Anderson CW, Appella E. Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J Biol Chem 2000; 275:9278-83. (Pubitemid 30185148)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.13
, pp. 9278-9283
-
-
Sakaguchi, K.1
Saito, S.2
Higashimoto, Y.3
Roy, S.4
Anderson, C.W.5
Appella, E.6
-
13
-
-
0033119627
-
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
-
Unger T, Juven-Gershon T, Moallem E, Berger M, Siononv RV, Lozano G, et al. Critical role for ser20 of human p53 in the negative regulation of p53 by MDM2. EMBO J 1999; 18:1805-14. (Pubitemid 29158524)
-
(1999)
EMBO Journal
, vol.18
, Issue.7
, pp. 1805-1814
-
-
Unger, T.1
Juven-Gershon, T.2
Moallem, E.3
Berger, M.4
Vogt, S.R.5
Lozano, G.6
Oren, M.7
Haupt, Y.8
-
14
-
-
0034142325
-
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
-
Chehab NH, Malikzay A, Appel M, Halazonetis TD. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev 2000; 14:278-88.
-
(2000)
Genes Dev
, vol.14
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.D.4
-
15
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase chk2
-
Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, et al. DNA damage-induced activation of p53 by the checkpoint kinase chk2. Science 2000; 287:1824-7.
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
Kong, Y.Y.2
Matsuoka, S.3
Wakeham, A.4
Ruland, J.5
Yoshida, H.6
-
16
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate, p53 at multiple DNA damage-inducible sites
-
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C. The human homologs of checkpoint kinases chk1 and cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 2000; 14:289-300. (Pubitemid 30106484)
-
(2000)
Genes and Development
, vol.14
, Issue.3
, pp. 289-300
-
-
Shieh, S.-Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
17
-
-
0035951809
-
Characterization of tumor-associated Chk2 mutations
-
Wu X, Webster SR, Chen J. Characterization of tumor-associated Chk2 mutations. J Biol Chem 2001; 276:2971-74.
-
(2001)
J Biol Chem
, vol.276
, pp. 2971-2974
-
-
Wu, X.1
Webster, S.R.2
Chen, J.3
-
18
-
-
0030575937
-
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
-
DOI 10.1126/science.274.5289.948
-
Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, et al. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 1996; 274:948-53. (Pubitemid 26398409)
-
(1996)
Science
, vol.274
, Issue.5289
, pp. 948-953
-
-
Kussie, P.H.1
Gorina, S.2
Marechal, V.3
Elenbaas, B.4
Moreau, J.5
Levine, A.J.6
Pavletich, N.P.7
-
19
-
-
0034114544
-
Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
-
DOI 10.1128/MCB.20.8.2803-2808.2000
-
Webley K, Bond JA, Jones CJ, Blaydes JP, Craig A, Hupp T, et al. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage. Mol Cell Biol 2000; 20:2803-8. (Pubitemid 30183499)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.8
, pp. 2803-2808
-
-
Webley, K.1
Bond, J.A.2
Jones, C.J.3
Blaydes, J.P.4
Craig, A.5
Hupp, T.6
Wynford-Thomas, D.7
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