Hyperglycaemia potentiates the teratogenicity of retinoic acid in diabetic pregnancy in mice

Diabetologia

Volumn 47, Issue 3, 2004, Pages 515-522

  Leung, M B W ^a   Choy, K W ^a   Copp, A J ^b   Pang, C P ^a   Shum, A S W ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Caudal regression; Cell death; Hyperglycaemia; Maternal diabetes; Mouse embryo; Retinoic acid; Wnt 3a

Indexed keywords

GLUCOSE; PHLORIZIN; RETINOIC ACID; WNT1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAUDAL REGRESSION SYNDROME; CELL DEATH; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOWN REGULATION; EMBRYO; FEMALE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; MALE; MOUSE; NONHUMAN; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENAL DIABETES; RISK FACTOR; TAIL; TERATOGENICITY;

ANIMALS; BLOOD GLUCOSE; DISEASE SUSCEPTIBILITY; EMBRYO; EMBRYONIC DEVELOPMENT; FEMALE; GLUCOSE; HYPERGLYCEMIA; MICE; PREGNANCY; PREGNANCY IN DIABETICS; TERATOGENS; TRETINOIN;

EID: 1842866376     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1350-6     Document Type: Article

References (44)

1. Chung CS, Myrianthopoulos NC (1975) Factors affecting the risks of congenital malformations. II. Effect of maternal diabetes on congenital malformations. Birth Defects Orig Artic Ser 11:23-38
2. Hawthorne G, Robson S, Ryall EA, Sen D, Roberts SH, Ward Platt MP (1997) Prospective population based survey of outcome of pregnancy in diabetic women: results of the Northern Diabetic Pregnancy Audit, 1994. BMJ 315:279-281
3. Mills JL, Baker L, Goldman AS (1979) Malformations in infants of diabetic mothers occur before the seventh gestational week: Implications for treatment. Diabetes 28:292-293
4. Reece EA, Homko CJ, Wu YK (1996) Multifactorial basis of the syndrome of diabetic embryopathy. Teratology 54: 171-182
5. Chan BW, Chan KS, Koide T et al. (2002) Maternal diabetes increases the risk of caudal regression caused by retinoic acid. Diabetes 51:2811-2816
6. Kitzmiller JL, Gavin LA, Gin GD, Jovanovic-Peterson L, Main EK, Zigrang WD (1991) Preconception care of diabetes. Glycemic control prevents congenital anomalies. JAMA 265:731-736
7. Langer O, Conway DL (2000) Level of glycemia and perinatal outcome in pregestational diabetes. J Matern Fetal Med 9:35-41
8. Suhonen L, Hiilesmaa V, Teramo K (2000) Glycaemic control during early pregnancy and fetal malformations in women with type I diabetes mellitus. Diabetologia 43:79-82
9. Gale TF (1991) Effects of in vivo exposure of pregnant hamsters to glucose. 1. Abnormalities in LVG strain fetuses following intermittent multiple treatments with two isomers. Teratology 44:193-202
10. Fine EL, Horal M, Chang TI, Fortin G, Loeken MR (1999) Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy. Diabetes 48:2454-2462
11. Sadler TW (1980) Effects of maternal diabetes on early embryogenesis: II. Hyperglycemia-induced exencephaly. Teratology 21:349-356
12. Wilkinson DG (1992) Whole mount in situ hybridisation of vertebrate embryos. In: Wilkinson DG (ed) In situ hybridisation. IRL Press, Oxford, pp 75-83
13. Roelink H, Nusse R (1991) Expression of two members of the Wnt family during mouse development - restricted temporal and spatial patterns in the developing neural tube. Genes Dev 5:381-388
14. Shum ASW, Poon LLM, Tang WWT et al. (1999) Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo. Mech Dev 84:17-30
15. Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA (1986) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 79:1510-1515
16. Eriksson UJ, Lewis NJ, Freinkel N (1984) Growth retardation during early organogenesis in embryos of experimentally diabetic rats. Diabetes 33:281-284
17. Phelan SA, Ito M, Loeken MR (1997) Neural tube defects in embryos of diabetic mice. Role of the Pax-3 gene and apoptosis. Diabetes 46:1189-1197
18. Shenefelt RE (1972) Morphogenesis of malformations in hamsters caused by retinoic acid: relations to dose and stage at treatment. Teratology 5:103-118
19. Wentzel P, Jansson L, Eriksson UJ (1995) Diabetes in pregnancy: uterine blood flow and embryonic development in the rat. Pediatr Res 28:598-606
20. Bavik C, Ward SJ, Chambon P (1996) Developmental abnormalities in cultured mouse embryos deprived of retinoic acid by inhibition of yolk-sac retinol binding protein synthesis. Proc Natl Acad Sci USA 93:3110-3114
21. Sapin V, Ward SJ, Bronner S, Chambon P, Dolle P (1997) Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse. Dev Dyn 208:199-210
22. Dollé P, Ruberte E, Leroy P, Morriss-Kay G, Chambon P (1990) Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis. Development 110:1133-1151
23. Ruberte E, Dolle P, Chambon P, Morriss-Kay G (1991) Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development 111: 45-60
24. Tuitoek PJ, Ritter SJ, Smith JE, Basu TK (1996) Streptozotocin-induced diabetes lowers retinol-binding protein and transthyretin concentrations in rats. Br J Nutr 76:891-897
25. Krill D, O'Leary L, Koehler AN et al. (1997) Association of retinol binding protein in multiple-case families with insulin-dependent diabetes. Hum Biol 69:89-96
26. Lu J, Dixon WT, Tsin AT, Basu TK (2000) The metabolic availability of vitamin A is decreased at the onset of diabetes in BB rats. J Nutr 130:1958-1962
27. Baena RM, Campoy C, Bayes R, Blanca E, Fernandez JM, Molina-Font JA (2002) Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus. Eur J Clin Nutr 56: 44-50
28. Abu-Abed S, Dolle P, Metzger D, Beckett B, Chambon P, Petkovich M (2001) The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structure. Genes Dev 15:226-240
29. Maden M (2000) The role of retinoic acid in embryonic and post-embryonic development. Proc Nutr Soc 59:65-73
30. Ozeki H, Shirai S (1998) Developmental eye abnormalities in mouse fetuses induced by retinoic acid. Jpn J Ophthalmol 42:162-167
31. Yasuda Y, Konishi H, Kihara T, Tanimura T (1987) Developmental anomalies induced by all-trans-retinoic acid in fetal mice: II. Induction of abnormal neuroepithelium. Teratology 35:355-366
32. Dickman ED, Thaller C, Smith SM (1997) Temporally-regulated retinoic acid depletion produces specific neural crest, ocular and nervous system defects. Development 124:3111-3121
33. Fujii H, Sato T, Kaneko S et al. (1997) Metabolic inactivation of retinoic acid by novel P450 differentially expressed in developing mouse embryos. EMBO J 16:4163-4173
34. Swindell EC, Thaller C, Sockanathan S, Petkovich M, Jessell TM, Eichele G (1999) Complementary domains of retinoic acid production and degradation in the early chick embryo. Dev Biol 216:282-296
35. Yamamoto Y, Zolfaghari R, Ross AC (2000) Regulation of CYP26 (cytochrome P450RAI) mRNA expression and retinoic acid metabolism by retinoids and dietary vitamin A in liver of mice and rats. FASEB J 14:2119-2127
36. Basu TK, Basualdo C (1997) Vitamin A homeostasis and diabetes mellitus. Nutrition 13:804-806
37. Olmedilla B, Granado F, Gil-Martinez E, Blanco I, Rojas-Hidalgo E (1997) Reference values for retinol, tocopherol, and main carotenoids in serum of control and insulin-dependent diabetic Spanish subjects. Clin Chem 43:1066-1071
38. Granado F, Olmedilla B, Gil-Martinez E, Blanco I, Millan I, Rojas-Hidalgo E (1998) Carotenoids, retinol and tocopherols in patients with insulin-dependent diabetes mellitus and their immediate relatives. Clin Sci (Lond) 94:189-195
39. Tuitoek PJ, Ziari S, Tsin AT, Rajotte RV, Suh M, Basu TK (1996) Streptozotocin-induced diabetes in rats is associated with impaired metabolic availability of vitamin A (retinol). Br J Nutr 75:615-622
40. Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P (1993) Function of retinoic acid receptor gamma in the mouse. Cell 73:643-658
41. Cui J, Michaille JJ, Jiang W, Zile MH (2003) Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by retinoic acid. Dev Biol 260:496-511
42. Haq RU, Pfahl M, Chytil F (1991) Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats. Proc Natl Acad Sci USA 88:8272-8276
43. Eckhoff CH, Nau H (1990) Vitamin A supplementation increases levels of retinoic acid compounds in human plasma: possible implications for teratogenesis. Arch Toxicol 64:502-503
44. Tzimas G, Collins MD, Burgin H, Hummler H, Nau H (1996) Embryotoxic doses of vitamin A to rabbits result in low plasma but high embryonic concentrations of all-trans-retinoic acid: risk of vitamin A exposure in humans. J Nutr 126:2159-2171