The transcription factor HACA mediates the unfolded protein response in Aspergillus niger, and up-regulates its own transcription

Molecular Genetics and Genomics

Volumn 271, Issue 2, 2004, Pages 130-140

  Mulder, H J ^a   Saloheimo, M ^b   Penttila M ^b   Madrid, S M ^a  

^a DANISCO A S   (Denmark)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

Author keywords

Endoplasmic reticulum stress; Foldases; HACA; Tissue plasminogen activator (t PA); Unfolded protein response (UPR)

Indexed keywords

CHAPERONE; DITHIOTHREITOL; MESSENGER RNA; TISSUE PLASMINOGEN ACTIVATOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BIPA; TRANSCRIPTION FACTOR CYPB; TRANSCRIPTION FACTOR HACA; TRANSCTIPTION FACTOR PDIA; TUNICAMYCIN; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS NIGER; ENDOPLASMIC RETICULUM; FUSION GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; IN VITRO STUDY; MOLECULAR CLONING; MYCELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING;

AMINO ACID SEQUENCE; ASPERGILLUS NIGER; BASE SEQUENCE; DITHIOTHREITOL; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, PLANT; GREEN FLUORESCENT PROTEINS; IMMUNOBLOTTING; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PLASMIDS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TISSUE PLASMINOGEN ACTIVATOR; TRANS-ACTIVATORS; TUNICAMYCIN; UP-REGULATION;

ASPERGILLUS; ASPERGILLUS NIGER;

EID: 1842787878     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-003-0965-5     Document Type: Article

References (39)

1. Archer DB, Peberdy JF (1997) The molecular biology of secreted enzyme production by fungi. Crit Rev Biotechnol 17:273-306
2. Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D (2000) Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2:326-332
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
4. Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415:92-96
5. Cox JS, Walter P (1996) A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87:391-404
6. Derkx PM, Madrid SM (2001a) The Aspergillus niger cypA gene encodes a cyclophilin that mediates sensitivity to the immunosuppressant cyclosporin A. Mol Genet Genomics 266:527-536
7. Derkx PM, Madrid SM (2001b) The foldase CYPB is a component of the secretory pathway of Aspergillus niger and contains the endoplasmic reticulum retention signal HEEL. Mol Genet Genomics 266:537-545
8. Ellgaard L, Molinari M, Helenius A (1999) Setting the standards: quality control in the secretory pathway. Science 286:1882-1888
9. Gasch AP, Spellman PT, Kao CM, Carmel-Harel O, Eisen MB, Storz G, Botstein D, Brown PO (2000) Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell 11:4241-4257
10. Gething MJ, Sambrook J (1992) Protein folding in the cell. Nature 355:33-45
11. Gonzalez TN, Sidrauski C, Dorfler S, Walter P (1999) Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J 18:3119-3132
12. Goosen T, Bloemheuvel G, Gysler C, de Bie DA, van den Broek HW, Swart K (1987) Transformation of Aspergillus niger using the homologous orotidine-5′-phosphate-decarboxylase gene. Curr Genet 11:499-503
13. Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D (2000) Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 6:1099-1108
14. Hinnebusch AG (1997) Translational regulation of yeast GCN4. A window on factors that control initiator-tRNA binding to the ribosome. J Biol Chem 272:21661-21664
15. Jeenes DJ, Pfaller R, Archer DB (1997) Isolation and characterisation of a novel stress-inducible PDI-family gene from Aspergillus niger. Gene 193:151-156
16. Kaufman RJ (1999) Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13:1211-1233
17. Kawahara T, Yanagi H, Yura T, Mori K (1997) Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response. Mol Biol Cell 8:1845-1862
18. Kusters-van Someren MA, Harmsen JA, Kester HC, Visser J (1991) Structure of the Aspergillus niger pelA gene and its expression in Aspergillus niger and Aspergillus nidulans. Curr Genet 20:293-299
19. Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ (2002) IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev 16:452-466
20. Meijer HA, Thomas AA (2002) Control of eukaryotic protein synthesis by upstream open reading frames in the 5′-untranslated region of an mRNA. Biochem J 367:1-11
21. Ngiam C, Jeenes DJ, Archer DB (1997) Isolation and characterisation of a gene encoding protein disulphide isomerase, pdiA, from Aspergillus niger. Curr Genet 31:133-138
22. Partaledis JA, Berlin V (1993) The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. Proc Natl Acad Sci USA 90:5450-5454
23. Patil C, Walter P (2001) Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol 13:349-355
24. Ruegsegger U, Leber JH, Walter P (2001) Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Cell 107:103-114
25. Saloheimo M, Valkonen M, Penttila M (2003) Activation mechanisms of the HACI-mediated unfolded protein response in filamentous fungi. Mol Microbiol 47:1149-1161
26. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual (2nd edn). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
27. Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ (2001) Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell 107:893-903
28. Sidrauski C, Walter P (1997) The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90:1031-1039
29. Sidrauski C, Cox JS, Walter P (1996) tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87:405-413
30. Sidrauski C, Chapman R, Walter P (1998) The unfolded protein response: an intracellular signalling pathway with many surprising features. Trends Cell Biol 8:245-249
31. Siebert PD, Chenchik A, Kellogg DE, Lukyanov KA, Lukyanov SA (1995) An improved PCR method for walking in uncloned genomic DNA. Nucleic Acids Res 23:1087-1088
32. Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weissman JS, Walter P (2000) Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101:249-258
33. Van Gemeren IA, Punt PJ, Drint-Kuyvenhoven A, Broekhuijsen MP, van't Hoog A, Beijersbergen A, Verrips CT, van den Hondel CA (1997) The ER chaperone encoding bipA gene of black Aspergilli is induced by heat shock and unfolded proteins. Gene 198:43-52
34. Vishniac W, Santer M (1957) The Thiobacilli. Bacteriol Rev 21:195-213
35. Wang H, Ward M (2000) Molecular characterization of a PDI-related gene, prpA, in Aspergillus niger var. awamori. Curr Genet 37:57-64
36. Welihinda AA, Tirasophon W, Kaufman RJ (1999) The cellular response to protein misfolding in the endoplasmic reticulum. Gene Expr 7:293-300
37. Wiebe MG, Karandikar A, Robson GD, Trinci AP, Candia JL, Trappe S, Wallis G, Rinas U, Derkx PM, Madrid SM, Sisniega H, Faus I, Montijn R, van den Hondel CA, Punt PJ (2001) Production of tissue plasminogen activator (t-PA) in Aspergillus niger. Biotechnol Bioeng 76:164-174
38. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107:881-891
39. Zapun A, Jakob CA, Thomas DY, Bergeron JJ (1999) Protein folding in a specialized compartment: the endoplasmic reticulum. Structure Fold Des 7:R173-R182