Methylation of cortical brain proteins from patients with HIV infection

Acta Neurologica Scandinavica

Volumn 100, Issue 5, 1999, Pages 326-331

  Goggins, Michael ^a,b   Scott, J M ^a   Weir, D G ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Alzheimer's disease; HIA encephalitis; Protein carboxmethyltransferase; Protein methylation; S adenosylhomocysteine; S adenosylmethionine

Indexed keywords

BRAIN PROTEIN; PROTEIN CARBOXYL METHYLTRANSFERASE; S ADENOSYLMETHIONINE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; ENCEPHALITIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MALE; NEUROPATHY; PROTEIN METHYLATION; SPINAL CORD ATROPHY;

EID: 0032842432     PISSN: 00016314     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0404.1999.tb00405.x     Document Type: Article

References (40)

1. LIPTON SA, GENDELMAN HE. Dementia associated with the acquired immune deficiency syndrome. N Engl J Med 1995;332:934-41.
2. MASLIAH E. In vivo modeling of HIV-1 mediated neuro-degeneration. Am J Pathol 1996;149:745-50.
3. TOGGAS SM, MASLIAH E, ROCKENSTEIN EM, RALL GF, ABRAHAM CR, MUCKE L. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 1994;367:188-93.
4. GOUDREAU G, CARPENTER S, BEAULIEU N, JOLICOEUR P. Vacuolar myelopathy in transgenic mice expressing human immunodeficiency virus type 1 proteins under the regulator of the myelin basic protein gene promoter. Nat Med 1996;2:655-61.
5. GLASS JD, WESSELINGH SL, SELNES OA, MCARTHUR JC. Clinical-neuropathologic correlation in HIV-associated dementia. Neurology 1993;43:2230-7.
6. EVERALL IP, LUTHERT PJ, LANTOS PL. Neuronal loss in the frontal cortex in HIV infection. Lancet 1991;337:1119-21.
7. WILEY CA, MASLIAH E, MOREY M et al. Neocortical damage during HIV infection. Ann Neurol 1991;29:651-7.
8. PEITTO CK, NOVIA BA, CHO ES. Vacuolar myelopathy pathologically resembling subacute combined degeneration in patients with the acquired immune deficiency syndrome. N Engl J Med 1985;312:874-9.
9. BUDKA H. Neuropathology of human immunodeficiency virus infection. Brain Pathol 1991;1:163-75.
10. ALBRIGHT AV, STRIZKI J, HAROUSE JM, LAVI E, O'CONNOR M, GONZALEZ-SCARANO F. HIV-1 infection of cultured human adult oligodendrocytes. Virology 1996;217:211-19.
11. BHAT S, SPITALNIK SL, GONZALEZ-SCARANO F, SILBERBERG DH. Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type I envelope glycoprotein gp120. Proc Natl Acad Sci USA 1991;88:7131-4.
12. KIMURA-KURODA J, NAGASHIMA K, YASUI K. Inhibition of myelin formation by HIV-1 gp120 in rat cerebral cortex culture. Arch Virol 1994;137:81-99.
13. SELMAJ KW, RINE CS. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 1988;23:339-46.
14. ROBBINS DS, SHIRAZI Y, DRYSDALE BE, LIEBERMAN A, SHIN HS, SHIN ML. Production of cytotoxic factors for oligodendrocytes by stimulated astrocytes. J Immunol 1987;139:2593-7.
15. BUZY J, BRENNEMAN DE, PERT CB, MARTIN A, SALAZAR A, RUFF MR. Potent gp120-like neurotoxic activity in the cerebrospinal fluid of HIV-infected individuals is blocked by peptide T. Brain Res 1992;598:10-18.
16. BRUCE AJ, BOLING W, KINDY MS et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 1996;2:788-94.
17. 12 inactivation. Clin Sci 1995;88:471-7.
18. KEATING JN, TRIMBLE KC, MULCAHY F, SCOTT JM, WEIR DG. Evidence of brain methyltransferase inhibition and early brain involvement in HIV-positive patients. Lancet 1991;337:935-9.
19. SURTEES R, HYLAND K, SMITH I. Central nervous system methyl-group metabolism in children with neurological complications of HIV infection. Lancet 1990;335:619-21.
20. CASTAGNA A, LE GRAZIE C, ACCORDINI A et al. Cerebrospinal fluid S-adenosylmethionine (SAMe) and glutathione concentrations in HIV infection: effect of parenteral treatment with SAMe. Neurology 1995;45:1678-83.
21. WEIR DG, MOLLOY AM, KEATING JN et al. Correlation of the ratio of S-adenosyl-L-methionine to S-adenosyl-L-homocysteine in the brain and cerebrospinal fluid of the pig: implications for the determination of this methylation ratio in human brain. Clin Sci 1992;82:93-7.
22. BERGMANN S, SHATROV V, RATTER F, SCHIEMANN S, SCHULZE-OSTHOFF K, LEHMANN V. S-adenosythomocysteine as a modulator of tumor necrosis factor (TNF)-mediated cytotoxicity: mode of action. J Immunol 1994;153:1736.
23. GOGGINS M, SCOTT JM, WEIR DG. Regional differences in protein methylation in postmortem human brain. Clin Sci 1998;94:677-85.
24. MCKEEVER M, MOLLOY A, WEIR DG et al. An abnormal methylation ratio induces hypomethylation in vitro in the brain of pig and man, but not in rat. Clin Sci 1995;88:73-9.
25. PAIK WK, KIM S. Protein methylase I. J Biol Chem 1968;243:2108-14.
26. KIM S. S-adenosylmethionine: protein-carboxyl O-methyl-transferase (protein methylase II). Methods Enzymol 1984;106:295-309.
27. DAWSON-SAUNDERS B, TRAPP RG. Basic and Clinical Biostatistics. Norwalk Connecticut: Appleton and Lange, 1994.
28. PERRY EK, PERRY RH, TOMLINSON BE. The influence of agonal status on some neurochemical activities of postmortem human brain tissue. Neurosci Lett 1982;29:303-7.
29. PERRY EK, PERRY RH. Human brain neurochemistry some postmortem problems. Life Sci 1983;33:1733-43.
30. BRAY GP, TREDGER JM, WILLIAMS R. S-adenosylmethionine protects against acetaminophen hepatotoxicity in two mouse models. Hepatology 1992;15:297-301.
31. SCOTT JM, WEIR DG. The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic acid-induced exacerbation of subacute combined degeneration. Lancet 1981;ii:337-40.
32. LERTRARANANGKOON K, SCIMECA JM. Prevention of bromobenzene toxicity by N-acetylmethionine: correlation between toxicity and impairment in O- and S-methylation of bromothiocatechols. Toxicol Appl Pharmacol 1993;122:191-9.
33. LERTRARANANGKOON K, ORKISZEWSKI RS, SCIMECA JM. Methyl-donor deficiency due to chemically induced glutathione depletion. Cancer Res 1996;56:995-1005.
34. SELHUR J, MILLER JW. The pathogenesis of homocysteinaemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and trans-sulphuration of homocysteine. Am J Clin Nutr 1992;55:131-8.
35. FINKELSTEIN JD, MARTIN JJ. Methionine metabolism in mammals: adaptation to methionine excess. J Biol Chem 1986;261:1582-7.
36. HORTIN GL, LANDT M, POWDERLY WG. Changes in plasma amino acid concentrations in response to HIV-1 infection. Clin Chem 1994;40:785-9.
37. STAAL FJ, ELA SW, ROEDERER M, ANDERSON MT, HERZENBERG LA. Glutathione deficiency and human immunodeficiency virus infection. Lancet 1992;339:909-12.
38. BUSCIGLIO J, YANKNER BA. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 1995;378:776-9.
39. ADAMS JD Jr. KLAIDMAN LK, ODUNZE IN, SHEN HC, MILLER CA. Alzheimer's disease and Parkinson's disease. Brain levels of glutathione, glutathione disulphide and vitamin E. Mol Chem Neuropathol 1991;14:213-26.
40. PERRY TL, YONG VW, BERGERON C, HANSEN S, JONES K. Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease. Ann Neurol 1987;21:331-6.