Overexpression of CREB reduces CRE-mediated transcription: Behavioral and cellular analyses in transgenic mice

Molecular and Cellular Neuroscience

Volumn 25, Issue 4, 2004, Pages 602-611

  Brodie, Christopher R ^a   Khaliq, Mahmooda ^a   Yin, Jerry C P ^b   Clark, H Brent ^a,c   Orr, Harry T ^a,c   Boland, Linda M ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

cAMP response element; cAMP response element binding transcription factor; CRE; CREB; Dentate gyrus; DG; Long term depression; Long term potentiation; LTD; LTP; Wild type; WT

Indexed keywords

BETA GALACTOSIDASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; SERINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATAXIA; BRAIN REGION; CYCLIC AMP RESPONSIVE ELEMENT; DENTATE GYRUS; GENETIC TRANSCRIPTION; GRANULE CELL; LONG TERM POTENTIATION; MOTOR PERFORMANCE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PURKINJE CELL; SIGNAL TRANSDUCTION; TASK PERFORMANCE; TRANSGENIC MOUSE;

ACTIVATING TRANSCRIPTION FACTORS; ANIMALS; BLOOD PROTEINS; CEREBELLUM; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DENTATE GYRUS; GENES, REPORTER; LAC OPERON; LONG-TERM POTENTIATION; MICE; MICE, TRANSGENIC; MOTOR SKILLS; MUSCULOSKELETAL EQUILIBRIUM; NEURONAL PLASTICITY; PHOSPHORYLATION; PURKINJE CELLS; RESPONSE ELEMENTS; TRANSCRIPTION FACTORS;

MUS MUSCULUS;

EID: 1842739589     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2003.11.008     Document Type: Article

References (49)

1. Abel T., Nguyen P.V., Barad M., Deuel T.A., Kandel E.R., Bourtchouladze R. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell. 88:1997;615-626.
2. Ahn S., Ginty D.D., Linden D.J. A late phase of cerebellar long-term depression requires activation of CaMKIV and CREB. Neuron. 2:1999;559-568.
3. Balschun D., Wolfer D.P., Gass P., Mantamadiotis T., Welzl H., Schutz G., Frey J.U., Lipp H.P. Does cAMP response element-binding protein have a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent memory? J. Neurosci. 23:2003;6304-6314.
4. Barrot M., Olivier J.D., Perrotti L.I., DiLeone R.J., Berton O., Eisch A.J., Impey S., Storm D.R., Neve R.L., Yin J.C., Zachariou V., Nestler E.J. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc. Natl. Acad. Sci. U. S. A. 99:2002;11435-11440.
5. Barski J.J., Hartmann J., Rose C.R., Hoebeek F., Morl K., Noll-Hussong M., De Zeeuw C.I., Konnerth A., Meyer M. Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination. J. Neurosci. 23:2003;3469-3477.
6. Bartsch D., Casadio A., Karl K.A., Serodio P., Kandel E.R. CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation. Cell. 95:1998;211-223.
7. Bourtchuladze R., Frenguelli B., Blendy J., Cioffi D., Schutz G., Silva A.J. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell. 79:1994;59-68.
8. Brindle P., Linke S., Montminy M. Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors. Nature. 364:1993;821-824.
9. Burright E.N., Clark H.B., Servadio A., Matilla T., Feddersen R.M., Yunis W.S., Duvick L.A., Zoghbi H.Y., Orr H.T. SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat. Cell. 82:1995;937-948.
10. Carlezon W.A. Jr., Thome J., Olson V.G., Lane-Ladd S.B., Brodkin E.S., Hiroi N., Duman R.S., Neve R.L., Nestler E.J. Regulation of cocaine reward by CREB. Science. 282:1998;2272-2275.
11. Chrivia J.C., Kwok R.P., Lamb N., Hagiwara M., Montminy M.R., Goodman R.H. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 365:1993;855-859.
12. Chung J.H., Whiteley M., Felsenfeld G. A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell. 74:1993;505-514.
13. De Zeeuw C.I., Hansel C., Bian F., Koekkoek S.K., van Alphen A.M., Linden D.J., Oberdick J. Expression of a protein kinase C inhibitor in Purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex. Neuron. 20:1998;495-508.
14. Frank D.A., Greenberg M.E. CREB: a mediator of long-term memory from mollusks to mammals. Cell. 79:1994;5-8.
15. Gass P., Wolfer D.P., Balschun D., Rudolph D., Frey U., Lipp H.P., Schutz G. Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learn. Mem. 5:1998;274-288.
16. Gerlai R., Friend W., Becker L., O'Hanlon D., Marks A., Roder J. Female transgenic mice carrying multiple copies of the human gene for S100 beta are hyperactive. Behav. Brain Res. 55:1993;51-59.
17. Gonzalez G.A., Montminy M.R. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell. 59:1989;675-680.
18. Hagiwara M., Brindle P., Harootunian A., Armstrong R., Rivier J., Vale W., Tsien R., Montminy M.R. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol. Cell. Biol. 13:1993;4852-4859.
19. Herdegen T., Leah J.D. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res. Brain Res. Rev. 28:1998;370-490.
20. Herdegen T., Gass P., Brecht S., Neiss W.F., Schmid W. The transcription factor CREB is not phosphorylated at serine 133 in axotomized neurons: implications for the expression of AP-1 proteins. Brain Res. Mol. Brain Res. 26:1994;259-270.
21. Impey S., Mark M., Villacres E.C., Poser S., Chavkin C., Storm D.R. Induction of CRE-mediated gene expression by stimuli that generatelong-lasting LTP in area CA1 of the hippocampus. Neuron. 16:1996;973-982.
22. 2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron. 21:1998;869-883.
23. Impey S., Smith D.M., Obrietan K., Donahue R., Wade C., Storm D.R. Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nat. Neurosci. 1:1998;595-600.
24. Josselyn S.A., Shi C., Carlezon W.A. Jr., Neve R.L., Nestler E.J., Davis M. Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala. J. Neurosci. 21:2001;2404-2412.
25. Kaufer D., Friedman A., Seidman S., Soreq H. Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature. 393:1998;373-377.
26. Kwok R.P., Lundblad J.R., Chrivia J.C., Richards J.P., Bachinger H.P., Brennan R.G., Roberts S.G., Green M.R., Goodman R.H. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature. 370:1994;223-226.
27. Kwok R.P., Laurance M.E., Lundblad J.R., Goldman P.S., Shih H., Connor L.M., Marriott S.J., Goodman R.H. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. Nature. 380:1996;642-646.
28. Lundblad J.R., Kwok R.P., Laurance M.E., Harter M.L., Goodman R.H. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature. 374:1995;85-88.
29. Matthies H., Schulz S., Thiemann W., Siemer H., Schmidt H., Krug M., Hollt V. Design of a multiple slice interface chamber and application for resolving the temporal pattern of CREB phosphorylation in hippocampal long-term potentiation. J. Neurosci. Methods. 30:1997;173-179.
30. Mayall T.P., Sheridan P.L., Montminy M.R., Jones K.A. Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro. Genes Dev. 11:1997;887-899.
31. Mayr B., Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell. Biol. 2:2001;599-609.
32. McLean J.H., Harley C.W., Darby-King A., Yuan Q. pCREB in the neonate rat olfactory bulb is selectively and transiently increased by odor preference-conditioned training. Learn. Mem. 6:1999;608-618.
33. Molina C.A., Foulkes N.S., Lalli E., Sassone-Corsi P. Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor. Cell. 75:1993;875-886.
34. Obrietan K., Impey S., Smith D., Athos J., Storm D.R. Circadian regulation of cAMP response element-mediated gene expression in the suprachiasmatic nuclei. J. Biol. Chem. 274:1999;17748-17756.
35. Parker D., Ferreri K., Nakajima T., LaMorte V.J., Evans R., Koerber S.C., Hoeger C., Montminy M.R. Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol. Cell. Biol. 16:1996;694-703.
36. Parker D., Jhala U.S., Radhakrishnan I., Yaffe M.B., Reyes C., Shulman A.I., Cantley L.C., Wright P.E., Montminy M. Analysis of an activator: coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol. Cell. 2:1998;353-359.
37. Pittenger C., Huang Y.Y., Paletzki R.F., Bourtchouladze R., Scanlin H., Vronskaya S., Kandel E.R. Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory. Neuron. 34:2002;447-462.
38. Rammes G., Steckler T., Kresse A., Schutz G., Zieglgansberger W., Lutz B. Synaptic plasticity in the basolateral amygdala in transgenic mice expressing dominant-negative cAMP response element-binding protein (CREB) in forebrain. Eur. J. Neurosci. 12:2000;2534-2546.
39. Richards J.P., Bachinger H.P., Goodman R.H., Brennan R.G. Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB. J. Biol. Chem. 271:1996;13716-13723.
40. Ruppert S., Cole T.J., Boshart M., Schmid E., Schutz G. Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes. EMBO J. 11:1992;1503-1512.
41. Sakai N., Thome J., Newton S.S., Chen J., Kelz M.B., Steffen C., Nestler E.J., Duman R.S. Inducible and brain region-specific CREB transgenic mice. Mol. Pharmacol. 61:2002;1453-1464.
42. Shaywitz A.J., Greenberg M.E. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu. Rev. Biochem. 68:1999;821-861.
43. Silva A.J., Kogan J.H., Frankland P.W., Kida S. CREB and memory. Annu. Rev. Neurosci. 21:1998;127-148.
44. Steidl J.V., Gomez-Isla T., Mariash A., Ashe K.H., Boland L.M. Altered short-term hippocampal synaptic plasticity in mutant a-synuclein transgenic mice. NeuroReport. 14:2003;219-223.
45. Vandaele S., Nordquist D.T., Feddersen R.M., Tretjakoff I., Peterson A.C., Orr H.T. Purkinje cell protein-2 regulatory regions and transgene expression in cerebellar compartments. Genes Dev. 5:1991;1136-1148.
46. Viola H., Furman M., Izquierdo L.A., Alonso M., Barros D.M., de Souza M.M., Izquierdo I., Medina J.H. Phosphorylated cAMP response element-binding protein as a molecular marker of memory processing in rat hippocampus: effect of novelty. J. Neurosci. 20(RC112):2000;1-5.
47. Wu X., Spiro C., Owen W.G., McMurray C.T. cAMP response element-binding protein monomers cooperatively assemble to form dimers on DNA. J. Biol. Chem. 273:1998;20820-20827.
48. Wu G.Y., Deisseroth K., Tsien R.W. Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc. Natl. Acad. Sci. U. S. A. 98:2001;2808-2813.
49. Yin J.C., Wallach J.S., Del Vecchio M., Wilder E.L., Zhou H., Quinn W.G., Tully T. Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell. 79:1994;49-58.