Modelling flavin and substrate substituent effects on the activation barrier and rate of oxygen transfer by p-hydroxybenzoate hydroxylase

FEBS Letters

Volumn 478, Issue 1-2, 2000, Pages 197-201

  Ridder, Lars ^a   Palfey, Bruce A ^b   Vervoort, Jacques ^a   Rietjens, Ivonne M C M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Bronsted correlation; Solvation effect; Substituent effect

Indexed keywords

4 HYDROXYBENZOIC ACID; FUNCTIONAL GROUP; OXYGENASE; QUERCETIN;

ARTICLE; CALCULATION; CATALYSIS; COMPUTER MODEL; CONTROLLED STUDY; CORRELATION FUNCTION; ENERGY; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SUBSTRATE; HYDROXYLATION; OXYGEN TRANSPORT; PRIORITY JOURNAL; REACTION ANALYSIS; SIMULATION; SOLVATION; STRUCTURE ACTIVITY RELATION;

4-HYDROXYBENZOATE-3-MONOOXYGENASE; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; ELECTROSTATICS; FLAVIN-ADENINE DINUCLEOTIDE; HYDROXYBENZOIC ACIDS; HYDROXYLATION; KINETICS; OXYGEN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 0034725979     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(00)01844-5     Document Type: Article

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