메뉴 건너뛰기




Volumn 559, Issue 1-2, 2004, Pages 177-187

Inhibitory effects of beer on heterocyclic amine-induced mutagenesis and PhIP-induced aberrant crypt foci in rat colon

Author keywords

2 amino 1 methyl 6 phenylimidazo 4,5 b pyridine; 2 amino 3,8 dimethylimidazo 4,5 f quinoxaline; 2 amino 3 methylimidazo 4,5 f quinoline; 3 amino 1 methyl 5H pyrido 4,3 b indole; Glu P 1; HCAs; Heterocyclic amines; IQ; MeIQx; PhIP; Trp P 2

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; 2 AMINO 6 METHYLDIPYRIDO[1,2 A:3',2' D]IMIDAZOLE; 3 AMINO 1 METHYL 5H PYRIDO[4,3 B]INDOLE; ANTIMUTAGENIC AGENT; ANTINEOPLASTIC AGENT; CYTOCHROME P450 1A2; HETEROCYCLIC AMINE; PHOSPHORUS 32; S 9;

EID: 1842579604     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2004.01.008     Document Type: Article
Times cited : (28)

References (43)
  • 2
    • 0030981184 scopus 로고    scopus 로고
    • Overview of carcinogenic heterocyclic amines
    • Sugimura T. Overview of carcinogenic heterocyclic amines. Mutat. Res. 376:1997;211-219.
    • (1997) Mutat. Res. , vol.376 , pp. 211-219
    • Sugimura, T.1
  • 3
    • 0025768966 scopus 로고
    • A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP)
    • Ito N., Hasegawa R., Sano M., Tamano S., Esumi H., Takayama S., Sugimura T. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 12:1991;1503-1506.
    • (1991) Carcinogenesis , vol.12 , pp. 1503-1506
    • Ito, N.1    Hasegawa, R.2    Sano, M.3    Tamano, S.4    Esumi, H.5    Takayama, S.6    Sugimura, T.7
  • 6
    • 0029889350 scopus 로고    scopus 로고
    • Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals
    • Nagao M., Wakabayashi K., Ushijima T., Toyota M., Totsuka Y., Sugimura T. Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals. Environ. Health Perspect. 104(Suppl. 3):1996;497-501.
    • (1996) Environ. Health Perspect. , vol.104 , Issue.SUPPL. 3 , pp. 497-501
    • Nagao, M.1    Wakabayashi, K.2    Ushijima, T.3    Toyota, M.4    Totsuka, Y.5    Sugimura, T.6
  • 7
    • 0023017251 scopus 로고
    • The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    • Felton J.S., Knize M.G., Shen N.H., Lewis P.R., Andresen B.D., Happe J., Hatch F.T. The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. 7:1986;1081-1086.
    • (1986) Carcinogenesis , vol.7 , pp. 1081-1086
    • Felton, J.S.1    Knize, M.G.2    Shen, N.H.3    Lewis, P.R.4    Andresen, B.D.5    Happe, J.6    Hatch, F.T.7
  • 8
    • 0028835983 scopus 로고
    • Cancer risk of heterocyclic amines in cooked foods: An analysis and implications for research
    • Layton D.W., Bogen K.T., Knize M.G., Hatch F.T., Johnson V.M., Felton J.S. Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. Carcinogenesis. 16:1995;39-52.
    • (1995) Carcinogenesis , vol.16 , pp. 39-52
    • Layton, D.W.1    Bogen, K.T.2    Knize, M.G.3    Hatch, F.T.4    Johnson, V.M.5    Felton, J.S.6
  • 9
    • 0026673950 scopus 로고
    • Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine
    • Turesky R.J., Rossi S.C., Welti D.H., Lay J.O. Jr., Kadlubar F.F. Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine. Chem. Res. Toxicol. 5:1992;479-490.
    • (1992) Chem. Res. Toxicol. , vol.5 , pp. 479-490
    • Turesky, R.J.1    Rossi, S.C.2    Welti, D.H.3    Lay Jr., J.O.4    Kadlubar, F.F.5
  • 10
    • 0031815379 scopus 로고    scopus 로고
    • Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2
    • Turesky R.J., Constable A., Richoz J., Varga N., Markovic J., Martin M.V., Guengerich F.P. Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2. Chem. Res. Toxicol. 11:1998;925-936.
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 925-936
    • Turesky, R.J.1    Constable, A.2    Richoz, J.3    Varga, N.4    Markovic, J.5    Martin, M.V.6    Guengerich, F.P.7
  • 11
    • 0026650976 scopus 로고
    • N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells
    • Minchin R.F., Reeves P.T., Teitel C.H., McManus M.E., Mojarrabi B., Ilett K.F., Kadlubar F.F. N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells. Biochem. Biophys. Res. Commun. 185:1992;839-844.
    • (1992) Biochem. Biophys. Res. Commun. , vol.185 , pp. 839-844
    • Minchin, R.F.1    Reeves, P.T.2    Teitel, C.H.3    McManus, M.E.4    Mojarrabi, B.5    Ilett, K.F.6    Kadlubar, F.F.7
  • 12
    • 0028952449 scopus 로고
    • Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s)
    • Chou H.C., Lang N.P., Kadlubar F.F. Metabolic activation of N-hydroxy arylamines and N-hydroxy heterocyclic amines by human sulfotransferase(s). Cancer Res. 55:1995;525-529.
    • (1995) Cancer Res. , vol.55 , pp. 525-529
    • Chou, H.C.1    Lang, N.P.2    Kadlubar, F.F.3
  • 13
    • 0031001829 scopus 로고    scopus 로고
    • Inhibition of PhIP mutagenicity by catechins, and by theaflavins and gallate esters
    • Apostolides Z., Balentine D.A., Harbowy M.E., Hara Y., Weisburger J.H. Inhibition of PhIP mutagenicity by catechins, and by theaflavins and gallate esters. Mutat. Res. 389:1997;167-172.
    • (1997) Mutat. Res. , vol.389 , pp. 167-172
    • Apostolides, Z.1    Balentine, D.A.2    Harbowy, M.E.3    Hara, Y.4    Weisburger, J.H.5
  • 14
    • 0030866720 scopus 로고    scopus 로고
    • The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: A structure-activity relationship study
    • Edenharder R., Rauscher R., Platt K.L. The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure-activity relationship study. Mutat. Res. 379:1997;21-32.
    • (1997) Mutat. Res. , vol.379 , pp. 21-32
    • Edenharder, R.1    Rauscher, R.2    Platt, K.L.3
  • 15
    • 0029964530 scopus 로고    scopus 로고
    • Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens
    • Dashwood R., Yamane S., Larsen R. Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens. Environ. Mol. Mutagen. 27:1996;211-218.
    • (1996) Environ. Mol. Mutagen. , vol.27 , pp. 211-218
    • Dashwood, R.1    Yamane, S.2    Larsen, R.3
  • 16
    • 0030868098 scopus 로고    scopus 로고
    • Chemoprevention by inducers of carcinogen detoxication enzymes
    • Kensler T.W. Chemoprevention by inducers of carcinogen detoxication enzymes. Environ. Health Perspect. 105(Suppl. 4):1997;965-970.
    • (1997) Environ. Health Perspect. , vol.105 , Issue.SUPPL. 4 , pp. 965-970
    • Kensler, T.W.1
  • 17
    • 0030837693 scopus 로고    scopus 로고
    • Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens
    • Sanyal R., Darroudi F., Parzefall W., Nagao M., Knasmuller S. Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens. Mutagenesis. 12:1997;297-303.
    • (1997) Mutagenesis , vol.12 , pp. 297-303
    • Sanyal, R.1    Darroudi, F.2    Parzefall, W.3    Nagao, M.4    Knasmuller, S.5
  • 18
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175:1988;184-191.
    • (1988) Exp. Cell Res. , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 19
    • 0030988121 scopus 로고    scopus 로고
    • Detection of chemically induced DNA lesions in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay
    • Sasaki Y.F., Tsuda S., Izumiyama F., Nishidate E. Detection of chemically induced DNA lesions in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow) using the alkaline single cell gel electrophoresis (Comet) assay. Mutat. Res. 388:1997;33-44.
    • (1997) Mutat. Res. , vol.388 , pp. 33-44
    • Sasaki, Y.F.1    Tsuda, S.2    Izumiyama, F.3    Nishidate, E.4
  • 20
    • 0037330680 scopus 로고    scopus 로고
    • Chemoprevention of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced colonic and hepatic preneoplastic lesions in the F344 rat by cruciferous vegetables administered simultaneously with the carcinogen
    • Kassie F., Uhl M., Rabot S., Grasl-Kraupp B., Verkerk R., Kundi M., Chabicovsky M., Schulte-Hermann R., Knasmuller S. Chemoprevention of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced colonic and hepatic preneoplastic lesions in the F344 rat by cruciferous vegetables administered simultaneously with the carcinogen. Carcinogenesis. 24:2003;255-261.
    • (2003) Carcinogenesis , vol.24 , pp. 255-261
    • Kassie, F.1    Uhl, M.2    Rabot, S.3    Grasl-Kraupp, B.4    Verkerk, R.5    Kundi, M.6    Chabicovsky, M.7    Schulte-Hermann, R.8    Knasmuller, S.9
  • 22
    • 0037294159 scopus 로고    scopus 로고
    • Direct reduction of N-acetoxy-PhIP by tea polyphenols: A possible mechanism for chemoprevention against PhIP-DNA adduct formation
    • Lin D.X., Thompson P.A., Teitel C., Chen J.S., Kadlubar F.F. Direct reduction of N-acetoxy-PhIP by tea polyphenols: a possible mechanism for chemoprevention against PhIP-DNA adduct formation. Mutat. Res. 523-524:2003;193-200.
    • (2003) Mutat. Res. , vol.523-524 , pp. 193-200
    • Lin, D.X.1    Thompson, P.A.2    Teitel, C.3    Chen, J.S.4    Kadlubar, F.F.5
  • 23
    • 0023629080 scopus 로고
    • Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings
    • Bird R.P. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett. 37:1987;147-151.
    • (1987) Cancer Lett. , vol.37 , pp. 147-151
    • Bird, R.P.1
  • 25
    • 0031416754 scopus 로고    scopus 로고
    • Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA)
    • Takahashi M., Totsuka Y., Masuda M., Fukuda K., Oguri A., Yazawa K., Sugimura T., Wakabayashi K. Reduction in formation of 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA). Carcinogenesis. 18:1997;1937-1941.
    • (1997) Carcinogenesis , vol.18 , pp. 1937-1941
    • Takahashi, M.1    Totsuka, Y.2    Masuda, M.3    Fukuda, K.4    Oguri, A.5    Yazawa, K.6    Sugimura, T.7    Wakabayashi, K.8
  • 26
    • 0032840096 scopus 로고    scopus 로고
    • Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in F344 rats
    • Chewonarin T., Kinouchi T., Kataoka K., Arimochi H., Kuwahara T., Vinitketkumnuen U., Ohnishi Y. Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in F344 rats. Food Chem. Toxicol. 37:1999;591-601.
    • (1999) Food Chem. Toxicol. , vol.37 , pp. 591-601
    • Chewonarin, T.1    Kinouchi, T.2    Kataoka, K.3    Arimochi, H.4    Kuwahara, T.5    Vinitketkumnuen, U.6    Ohnishi, Y.7
  • 28
    • 0028342393 scopus 로고
    • Determination of proanthocyanidins and catechins in beer and barley by high-performance liquid chromatography with dual-electrode electrochemical detection
    • Madigan D., McMurrough I., Smyth M.R. Determination of proanthocyanidins and catechins in beer and barley by high-performance liquid chromatography with dual-electrode electrochemical detection. Analyst. 119:1994;863-868.
    • (1994) Analyst , vol.119 , pp. 863-868
    • Madigan, D.1    McMurrough, I.2    Smyth, M.R.3
  • 29
    • 0032900267 scopus 로고    scopus 로고
    • Inhibitory effects of beer and other alcoholic beverages on mutagenesis and DNA adduct formation induced by several carcinogens
    • Arimoto-Kobayashi S., Sugiyama C., Harada N., Takeuchi M., Takemura M., Hayatsu H. Inhibitory effects of beer and other alcoholic beverages on mutagenesis and DNA adduct formation induced by several carcinogens. J. Agric. Food Chem. 47:1999;221-230.
    • (1999) J. Agric. Food Chem. , vol.47 , pp. 221-230
    • Arimoto-Kobayashi, S.1    Sugiyama, C.2    Harada, N.3    Takeuchi, M.4    Takemura, M.5    Hayatsu, H.6
  • 30
    • 0032967520 scopus 로고    scopus 로고
    • Glycine betaine in beer as an antimutagenic substance against 2-chloro-4-methylthiobutanoic acid, the sanma-fish mutagen
    • Kimura S., Hayatsu H., Arimoto-Kobayashi S. Glycine betaine in beer as an antimutagenic substance against 2-chloro-4-methylthiobutanoic acid, the sanma-fish mutagen. Mutat. Res. 439:1999;267-276.
    • (1999) Mutat. Res. , vol.439 , pp. 267-276
    • Kimura, S.1    Hayatsu, H.2    Arimoto-Kobayashi, S.3
  • 31
  • 32
    • 0033964084 scopus 로고    scopus 로고
    • Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells
    • Miranda C.L., Aponso G.L., Stevens J.F., Deinzer M.L., Buhler D.R. Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells. Cancer Lett. 149:2000;21-29.
    • (2000) Cancer Lett. , vol.149 , pp. 21-29
    • Miranda, C.L.1    Aponso, G.L.2    Stevens, J.F.3    Deinzer, M.L.4    Buhler, D.R.5
  • 33
    • 0016685233 scopus 로고
    • Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test
    • Ames B.N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 31:1975;347-364.
    • (1975) Mutat. Res. , vol.31 , pp. 347-364
    • Ames, B.N.1    McCann, J.2    Yamasaki, E.3
  • 35
    • 0029900928 scopus 로고    scopus 로고
    • Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat
    • Xu M., Bailey A.C., Hernaez J.F., Taoka C.R., Schut H.A., Dashwood R.H. Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis. 17:1996;1429-1434.
    • (1996) Carcinogenesis , vol.17 , pp. 1429-1434
    • Xu, M.1    Bailey, A.C.2    Hernaez, J.F.3    Taoka, C.R.4    Schut, H.A.5    Dashwood, R.H.6
  • 38
    • 0029871426 scopus 로고    scopus 로고
    • Inhibition of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-mediated DNA-adduct formation by chlorophyllin in Drosophila
    • Sugiyama C., Shinoda A., Hayatsu H., Negishi T. Inhibition of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-mediated DNA-adduct formation by chlorophyllin in Drosophila. Jpn. J. Cancer Res. 87:1996;325-328.
    • (1996) Jpn. J. Cancer Res. , vol.87 , pp. 325-328
    • Sugiyama, C.1    Shinoda, A.2    Hayatsu, H.3    Negishi, T.4
  • 39
    • 0034027685 scopus 로고    scopus 로고
    • In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus
    • Henderson M.C., Miranda C.L., Stevens J.F., Deinzer M.L., Buhler D.R. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica. 30:2000;235-251.
    • (2000) Xenobiotica , vol.30 , pp. 235-251
    • Henderson, M.C.1    Miranda, C.L.2    Stevens, J.F.3    Deinzer, M.L.4    Buhler, D.R.5
  • 40
    • 0036319611 scopus 로고    scopus 로고
    • Chemoprotective effects of garden cress (Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced genotoxic effects and colonic preneoplastic lesions
    • Kassie F., Rabot S., Uhl M., Huber W., Qin H.M., Helma C., Schulte-Hermann R., Knasmuller S. Chemoprotective effects of garden cress (Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo[4,5-f] quinoline (IQ)-induced genotoxic effects and colonic preneoplastic lesions. Carcinogenesis. 23:2002;1155-1161.
    • (2002) Carcinogenesis , vol.23 , pp. 1155-1161
    • Kassie, F.1    Rabot, S.2    Uhl, M.3    Huber, W.4    Qin, H.M.5    Helma, C.6    Schulte-Hermann, R.7    Knasmuller, S.8
  • 41
    • 0037044110 scopus 로고    scopus 로고
    • Suppression of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced DNA damage in rat colon after grapefruit juice intake
    • Miyata M., Takano H., Takahashi K., Sasaki Y.F., Yamazoe Y. Suppression of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced DNA damage in rat colon after grapefruit juice intake. Cancer Lett. 183:2002;17-22.
    • (2002) Cancer Lett. , vol.183 , pp. 17-22
    • Miyata, M.1    Takano, H.2    Takahashi, K.3    Sasaki, Y.F.4    Yamazoe, Y.5
  • 42
    • 0035964461 scopus 로고    scopus 로고
    • Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine
    • Hagiwara A., Miyashita K., Nakanishi T., Sano M., Tamano S., Kadota T., Koda T., Nakamura M., Imaida K., Ito N., Shirai T. Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine. Cancer Lett. 171:2001;17-25.
    • (2001) Cancer Lett. , vol.171 , pp. 17-25
    • Hagiwara, A.1    Miyashita, K.2    Nakanishi, T.3    Sano, M.4    Tamano, S.5    Kadota, T.6    Koda, T.7    Nakamura, M.8    Imaida, K.9    Ito, N.10    Shirai, T.11
  • 43
    • 18344394946 scopus 로고    scopus 로고
    • Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine
    • Hagiwara A., Yoshino H., Ichihara T., Kawabe M., Tamano S., Aoki H., Koda T., Nakamura M., Imaida K., Ito N., Shirai T. Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. J. Toxicol. Sci. 27:2002;57-68.
    • (2002) J. Toxicol. Sci. , vol.27 , pp. 57-68
    • Hagiwara, A.1    Yoshino, H.2    Ichihara, T.3    Kawabe, M.4    Tamano, S.5    Aoki, H.6    Koda, T.7    Nakamura, M.8    Imaida, K.9    Ito, N.10    Shirai, T.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.