Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 397, Issue 2, 1998, Pages 203-208

  Vijayalaxmi, ^a   Reiter, Russel J ^a   Herman, Terence S ^a   Meltz, Martin L ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Comet assay; Gamma radiation; Melatonin; Primary DNA damage; Radioprotection

Indexed keywords

MELATONIN;

ARTICLE; CHROMOSOME ABERRATION; DNA DAMAGE; GAMMA RADIATION; HUMAN; HUMAN CELL; LYMPHOCYTE; MUTAGENESIS; PRIORITY JOURNAL; RADIATION PROTECTION;

ADMINISTRATION, ORAL; ADULT; DNA DAMAGE; FEMALE; GAMMA RAYS; HUMANS; LYMPHOCYTES; MALE; MELATONIN; MIDDLE AGED; MUTATION; REFERENCE VALUES;

EID: 0032472921     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00211-X     Document Type: Article

References (24)

1. Reiter R.J. The pineal gland and its hormones in the control of reproduction in mammals. Endocr. Rev. 1:1980;109-131.
2. Reiter R.J. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocr. Rev. 12:1991;151-180.
3. Reiter R.J. The ageing pineal gland and its physiological consequences. BioEssays. 14:1992;169-175.
4. Vijayalaxmi, Reiter R.J., Meltz M.L. Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutation Res. 346:1995;23-31.
5. Vijayalaxmi, Reiter R.J., Sewerynek E., Poeggeler B., Leal B.Z., Meltz M.L. Marked reduction of radiation-induced micronuclei in human blood lymphocytes pre-treated with melatonin. Radiat. Res. 143:1995;102-106.
6. Vijayalaxmi, Reiter R.J., Herman T.S., Meltz M.L. Melatonin and radioprotection from genetic damage: in vivo/in vitro studies with human volunteers. Mutation Res. 371:1996;221-228.
7. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175:1988;184-191.
8. Vijayalaxmi, Tice R.R., Strauss G.H.S. Assessment of radiation-induced DNA damage in human blood lymphocytes using the single-cell gel electrophoresis technique. Mutation Res. 271:1992;243-252.
9. Vijayalaxmi, Strauss G.H.S., Tice R.R. An anlysis of γ-ray-induced DNA damage in human blood leukocytes, lymphocytes and granulocytes. Mutation Res. 292:1993;123-128.
10. McKelvey-Martin V.J., Green M.H.L., Schmezer P., Pool-Zobel B.L., De Meo M.P., Collins A. The single cell electrophoresis assay (comet assay): a European review. Mutation Res. 288:1993;47-63.
11. Fairbain D.W., Olive P.L., O'Neill K.L. The comet assay: a comprehensive review. Mutation Res. 339:1995;37-59.
12. Fraser S., Cowen P., Franklin M., Franey C., Arendt J. Direct radioimmunoassay for melatonin in plasma. Clin. Chem. 29:1983;396-397.
13. Singh N.P., Stephens R.E., Schneider E.L. Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int. J. Radiat. Biol. 66:1994;23-28.
14. 2 and γ-irradiation with the alkaline comet assay. Mutation Res. 383:1997;71-80.
15. Reiter R.J. Melatonin: that ubiquitously acting pineal hormone. News Physiol. Sci. 6:1991;223-227.
16. Menendez-Pelaez A., Reiter R.J. Distribution of melatonin in mammalian tissues: the relative importance of nuclear versus cytosolic localization. J. Pineal Res. 15:1993;59-69.
17. Tan D.-X., Chen L.D., Poeggeler B., Manchester L.C., Reiter R.J. Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr. J. 1:1993;57-60.
18. Pieri C., Marra M., Moroni F., Recchioni R., Marcheselli F. Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci. 55:1994;PL271-PL276.
19. Gilad E., Cuzzocrea S., Zingarelli B., Salzman A.L., Szaba C. Melatonin is a scavenger of peroxynitrite. Life Sci. 60:1997;PL169-PL174.
20. Reiter R.J. Antioxidant actions of melatonin. Adv. Pharmacol. 38:1997;103-117.
21. Reiter R.J. Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicals. Eur. J. Endocrinol. 134:1996;412-420.
22. Reppert S.M., Weaver D.R., Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian rhythms. Neuron. 13:1994;1177-1185.
23. Barlow-Walden L.R., Reiter R.J., Abe M., Pablos M., Menendez-Pelaez A., Chen L.D., Poeggeler B. Melatonin stimulates brain glutathione peroxide activity. Neurochem. Int. 26:1995;497-502.
24. Carlberg C., Wiesenberg I. The orphan receptor family RZR/ROR, melatonin and 5-lipoxygenase:an unexpected relationships. J. Pineal Res. 18:1995;171-178.