Indium-Mediated Atom-Transfer and Reductive Radical Cyclizations of Iodoalkynes: Synthesis and Biological Evaluation of HIV-Protease Inhibitors

Journal of Organic Chemistry

Volumn 69, Issue 7, 2004, Pages 2417-2422

  Yanada, Reiko ^a   Koh, Yasuhiro ^b   Nishimori, Nobuaki ^a   Matsumura, Akira ^a   Obika, Shingo ^a   Mitsuya, Hiroaki ^b,c   Fujii, Nobutaka ^a   Takemoto, Yoshiji ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYME INHIBITION; INDIUM; SYNTHESIS (CHEMICAL);

CYCLIZATION PRODUCTS; RADICAL CYCLIZATION;

HYDROCARBONS;

ALKYNE; AMPRENAVIR; DIPEPTIDE DERIVATIVE; ETHYLAMINE; HYDROXYETHYLAMINE DIPEPTIDE; INDIUM; IODINE DERIVATIVE; METHANOL; N IODOSUCCINIMIDE; PROTEINASE INHIBITOR; SAQUINAVIR; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYCLIZATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MULTIDRUG RESISTANCE; NONHUMAN; OPTICAL ROTATION; REACTION ANALYSIS; REDUCTION; STEREOCHEMISTRY;

COMBINATORIAL CHEMISTRY TECHNIQUES; CYCLIZATION; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, VIRAL; HIV PROTEASE INHIBITORS; HIV-1; HYDROCARBONS, IODINATED; INDIUM; INHIBITORY CONCENTRATION 50; MOLECULAR MIMICRY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1842504104     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo035482m     Document Type: Article

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