Tec1p-Independent Activation of a Hypha-Associated Candida albicans Virulence Gene during Infection

Infection and Immunity

Volumn 72, Issue 4, 2004, Pages 2386-2389

  Staib, Peter ^a   Binder, Ayfer ^a   Kretschmar, Marianne ^b   Nichterlein, Thomas ^b   Schröppel, Klaus ^c   Morschhäuser, Joachim ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TEC1P; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANDIDA ALBICANS; CONSENSUS SEQUENCE; DELETION MUTANT; ENVIRONMENTAL FACTOR; FUNGAL GENE; FUNGAL VIRULENCE; FUNGUS HYPHAE; GENE DELETION; GENE EXPRESSION REGULATION; GENE INDUCTION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SAP5 GENE; TRANSCRIPTION REGULATION;

ANIMALS; ASPARTIC ENDOPEPTIDASES; CANDIDA ALBICANS; CANDIDIASIS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; HYPHAE; MICE; PERITONITIS; PROMOTER REGIONS (GENETICS); TRANSCRIPTION FACTORS; VIRULENCE;

EID: 1842483548     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.4.2386-2389.2004     Document Type: Article

References (24)

1. Andrianopoulos, A., and W. E. Timberlake. 1994. The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control development. Mol. Cell. Biol. 14:2503-2515.
2. Braun, B. R., W. S. Head, M. X. Wang, and A. D. Johnson. 2000. Identification and characterization of TUP1-regulated genes in Candida albicans. Genetics 156:31-44.
3. Brown, A. J., and N. A. Gow. 1999. Regulatory networks controlling Candida albicans morphogenesis. Trends Microbiol. 7:333-338.
4. Calderone, R. A., and W. A. Fonzi. 2001. Virulence factors of Candida albicans. Trends Microbiol. 9:327-335.
5. Ernst, J. F. 2000. Transcription factors in Candida albicans - environmental control of morphogenesis. Microbiology 146:1763-1774.
6. Gavrias, V., A. Andrianopoulos, C. J. Gimeno, and W. E. Timberlake. 1996. Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth. Mol. Microbiol. 19:1255-1263.
7. Hube, B., M. Monod, D. A. Schofield, A. J. Brown, and N. A. Cow. 1994. Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol. Microbiol. 14:87-99.
8. Köhler, G. A., T. C. White, and N. Agabian. 1997. Overexpression of a cloned IMP dehydrogenase gene of Candida albicans corders resistance to the specific inhibitor mycophenolic acid. J. Bacteriol. 179:2331-2338.
9. Kretschmar, M., B. Hube, T. Bertsch, D. Sanglard, R. Merker, M. Schröder, H. Hof, and T. Nichterlein. 1999. Germ tubes and proteinase activity con tribute to virulence of Candida albicans in murine peritonitis. Infect. Immun. 67:6637-6642.
10. Lane, S., C. Birse, S. Zhou, R. Matson, and H. Liu. 2001. DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans. J. Biol. Chem. 276:48988-48996.
11. Leng, P., P. R. Lee, H. Wu, and A. J. Brown. 2001. Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein. J. Bacteriol. 183:4090-4093.
12. Liu, H. 2001. Transcriptional control of dimorphism in Candida albicans. Curr. Opin. Microbiol. 4:728-735.
13. Liu, H., J. Köhler, and G. R. Finla 1994. Suppression of hyphal formation in Candida albfcans by mutation of a STE12 homolog. Science 266:1723-1726.
14. Lo, H. J., J. R. Köhler, B. DiDomenico, D. Loebenberg, A. Cacciapuoti, and G. R. Fiak. 1997. Nonfilamentous C. albicans mutants are avirulent. Cell 90:939-949.
15. Mitchell, A. P. 1998. Dimorphism and virulence in Candida albicans. Curr. Opin. Microbiol. 1:687-692.
16. Ramon, A. M., and W. A. Fonzi. 2003. Diverged binding specificity of Rim101p, the Candida albicans ortholog of PacC. Eukaryot. Cell 2:718-728.
17. Sanglard, D., B. Huhe, M. Monod, F. C. Odds, and N. A. Gow. 1997. A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5 and SAP6 of Candida albicans causes attenuated virulence. Infect. Immun. 65:3539-3546.
18. Schröppel, K., K. Sprößer, M. Whiteway, D. Y. Thomas, M. Röllinghoff, and C. Csanla 2000. Repression of hyphal proteinase expression by the mitogen activated protein (MAP) kinase phosphatase Cpp1p of Candida albicans is independent of the MAP kinase Cek1p. Infect. Immun. 68:7159-7161.
19. Schweizer, A., S. Rupp, B. N. Taylor, M. Röllinghoff, and K. Schriippel. 2000. The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans. Mol. Microbiol. 38:435-445.
20. Staib, P., M. Kretschmar, T. Nichterlein, H. Hof, and J. Morschhäuser. 2000. Differential activation of a Candida albicans virulence gene family during infection. Proc. Natl. Acad. Sci. USA 97:6102-6107.
21. Staib, P., M. Kretschmar, T. Nichterlein, H. Hof, and J. Morschhäuser. 2002. Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection. Infect. Immun. 70: 921-927.
22. Staib, P., M. Kretschmar, T. Nichterlein, G. Köhler, S. Michel, H. Hof, J. Hacker, and J. Morschhäuser. 1999. Host-induced, stage-specific virulence gene activation in Candida albicans during infection. Mol. Microbiol. 32: 533-546.
23. Stoldt, V. R., A. Sonneborn, C. E. Leuker, and J. F. Ernst. 1997. Efglp, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J. 16:1982-1991.
24. Whiteway, M. 2000. Transcriptional control of cell type and morphogenesis in Candida albicans. Curr. Opin. Microbiol. 3:582-588.