CRTH2

Journal of Biological Regulators and Homeostatic Agents

Volumn 17, Issue 4, 2003, Pages 334-337

  Nagata, Kinya ^a  

^a Kawagoe shi   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; CHEMOKINE; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; PROSTAGLANDIN D2; PROSTAGLANDIN RECEPTOR; PROTEIN CRTH2; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ALLERGY; AMINO ACID COMPOSITION; AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME 11; DENDRITIC CELL; EXON; GENE EXPRESSION; GENE LOCATION; HELPER CELL; HUMAN; INTRON; KNOCKOUT MOUSE; LYMPHOCYTE; MOLECULAR CLONING; MOLECULAR WEIGHT; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 1842476067     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Nagata K, Tanaka K, Ogawa K, et al. Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol 1999; 162: 1278-86.
2. Abe H, Takeshita T, Nagata K, et al. Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family. Gene 1999; 227: 71-7.
3. Yokomizo T, Kato K, Terawaki K, Izumi T, Shimizu T. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med 2000; 192: 421-32.
4. Hirai H, Tanaka K, Yoshie O, et al. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 2001; 193: 255-61.
5. Izumi T, Yokomizo T, Obinata H, Ogasawara H, Shimizu T. Leukotriene receptors: Classification, gene expression, and signal transduction. J Biochem 2002; 132: 1-6.
6. Sawyer N, Cauchon E, Chateauneuf A, et al. Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol 2002; 137: 1163-72.
7. Hsu SC, Chen LC, Kuo ML, Huang JL, Huang SK. Novel SNPs in a candidate gene, CRTH2, for allergic diseases. Genes Immun 2002; 3: 114-6.
8. Marchese A, Sawzdargo M, Nguyen T, et al. Discovery of three novel orphan G-protein-coupled receptors. Genomics 1999; 56: 12-21.
9. Nagata K, Hirai H, Tanaka K, et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett 1999; 459: 195-9.
10. Cosmi L, Annunziato F, Galli MIG, Maggi RME, Nagata K, Romagnani S. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur J Immunol 2000; 30: 2972-9.
11. Tsuda H, Michimata T, Sakai M, Nagata K, Nakamura M, Saito S. A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4+ and CD8+ T cells during the early stage of pregnancy. Clin Exp Immunol 2001; 123: 105-11.
12. Annunziato F, Cosmi L, Manetti R, et al. Reversal of human allergen-specific CRTH2+ T(H)2 cells by IL-12 or the PS-DSP30 oligodeoxynucleotide. J Allergy Clin Immunol 2001; 108: 815-21.
13. Iwasaki M, Nagata K, Takano S, Takahashi K, Ishii N, Ikezawa Z. Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. J Invest Dermatol 2002; 119: 609-16.
14. Messi M, Giacchetto I, Nagata K, Lanzavecchia A, Natoli G, Sallusto F. Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat Immunol 2003; 4: 78-86.
15. Cosmi L, Annunziato F, Galli G, Manetti R, Maggi E, Romagnani S. CRTH2: Marker for the detection of human Th2 and Tc2 cells. Adv Exp Med Biol 2001; 495: 25-9.
16. Nakajima T, Matsumoto K, Suto H, et al. Gene expression screening of human mast cells and eosinophils using high-density oligonucleotide probe arrays: Abundant expression of major basic protein in mast cells. Blood 2001; 98: 1127-34.
17. Michimata T, Tsuda H, Sakai M, et al. Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D(2)-mediated manner. Mol Hum Reprod 2002; 8: 181-7.
18. Monneret G, Li H, Vasilescu J, Rokach J, Powell WS. 15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils. J Immunol 2002; 168: 3563-9.
19. Hirai H, Tanaka K, Takano S, Ichimasa M, Nakamura M, Nagata K. Cutting edge: Agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2. J Immunol 2002; 168: 981-5.
20. Monneret G, Gravel S, Diamond M, Rokach J, Powell WS. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 2001; 98: 1942-8.
21. Gervais FG, Cruz RP, Chateauneuf A, et al. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP. J Allergy Clin Immunol 2001; 108: 982-8.