A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4+ and CD8+ T cells during the early stage of pregnancy

Clinical and Experimental Immunology

Volumn 123, Issue 1, 2001, Pages 105-111

  Tsuda, H ^a   Michimata, T ^a   Sakai, M ^a   Nagata, K ^b   Nakamura, M ^c   Saito, Shigeru ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b BML   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

CRTH2; Pregnancy; Tc2; Th2; Uterus

Indexed keywords

CD16 ANTIGEN; CD20 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; MEMBRANE ANTIGEN; PROTEIN CRTH2; UNCLASSIFIED DRUG;

ABORTION; ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DECIDUA; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TC2 CELL; TH2 CELL;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; CYTOKINES; DECIDUA; FEMALE; FLOW CYTOMETRY; HUMANS; LYMPHOCYTE COUNT; PREGNANCY; PREGNANCY PROTEINS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; T-LYMPHOCYTES, CYTOTOXIC; TH2 CELLS;

EID: 0035143993     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01422.x     Document Type: Article

References (40)

1. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
2. The expanding universe of T cell subsets - Th1, Th2 and more
3. Lymphokine production by human T cells in disease states
4. + T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis
5. A Th1/Th2 switch is a critical step in the etiology of HIV infection
6. Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon?
7. Synthesis of T helper 2-type cytokines at the maternal-fetal interface
8. Deferential cytokine expression in maternal blood and placenta during murine gestation
9. IL-10 prevents naturally occurring fetal loss in the CBAxDBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is occurred by in vivo injection of IFN-t
10. Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFNγ responses and increased production of T helper 2 cytokines
11. T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions
12. Characterization of type 1 and type 2 cytokine profile in physiologic and pathologic human pregnancy
13. Increased numbers of circulating interferon-gamma and interleukin-4-secreting cells during normal pregnancy
14. Evidence for reduced Th1 function in normal pregnancy: A hypothesis for the remission of rheumatoid arthritis
15. Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions
16. Distribution of Th1, Th2 and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells
17. Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia
18. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry
19. Selective expression of a novel surface molecule by human Th2 cells in vivo
20. CRTH2 an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)
21. Expression of activation CD69, HLA-DR, interleukin-2 receptor-alpha (IL-2Rα) and IL-2Rβ on T cells of human decidua at an early stage of pregnancy
22. + natural killer cells with high affinity interleukin 2 receptors in human early pregnancy decidua
23. + T cells are associated with IFN-gamma production
24. + T cells producing Th2-type cytokines
25. Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells
26. P- and E-selection mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
27. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
28. CCR5 is characteristic of Th1 lymphocytes
29. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
30. Chemokines. Signal lamps for trafficking of T and B cells for development and effector function
31. CCR5 is characteristic of Th1 lymphocytes
32. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes
33. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
34. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1 s) and Th2s
35. Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine
36. The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells
37. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor
38. Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo
39. A study of CD45RA and CD29 antigen expression on human decidual T cells in an early stage of pregnancy
40. Evidence for an elevation in serum interleukin-2 and tumor necrosis factor-α levels before the clinical manifestations of preeclampsia