Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80. II. In vivo degradation

Biomaterials

Volumn 19, Issue 21, 1998, Pages 1981-1988

  Leach, Kathleen J ^a,b   Takahashi, Shoji ^a   Mathiowitz, Edith ^a  

^a BROWN UNIVERSITY   (United States)

^b University of Washington   (United States)

Author keywords

Double walled microspheres; In vivo degradation; Poly(lactic acid); Polyanhydride

Indexed keywords

BIODEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; EXTRACTION; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; IMPLANTS (SURGICAL); OPTICAL MICROSCOPY; SCANNING ELECTRON MICROSCOPY; TISSUE;

DOUBLE WALLED MICROSPHERES; POLYANHYDRIDE; POLYLACTIC ACID;

BIOPOLYMERS;

CHLOROFORM; MICROSPHERE; POLYANHYDRIDE; POLYLACTIC ACID;

ANIMAL MODEL; ARTICLE; DEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; GEL PERMEATION CHROMATOGRAPHY; HISTOLOGY; IMPLANT; IN VIVO STUDY; INFRARED SPECTROSCOPY; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY;

ANIMALIA;

EID: 0032213705     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0142-9612(98)00109-4     Document Type: Article

References (3)

1. [1] Pekarek KJ, Jacob JS, Mathiowitz E. Double-walled polymer microspheres for controlled drug release. Nature 1994;367: 258-60.
2. [2] Pekarek KJ, Dyrud MJ, Ferrer K, Jong YS, Mathiowitz E. In vitro and in vivo degradation of double-walled polymer microspheres. Controlled Release 1996;40:169-78.
3. [3] Nakamura T, Hitoomi S, Watanabe S, Shimizu Y, Jamshidi K, Hyon S-H, Ikada Y. Bioabsorption of polylactides with different molecular properties. J. Biomed Mater Res 1989;23:1115-30.