Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80. I. In vitro degradation

Biomaterials

Volumn 19, Issue 21, 1998, Pages 1973-1980

  Leach, Kathleen J ^a,b   Mathiowitz, Edith ^a  

^a BROWN UNIVERSITY   (United States)

^b University of Washington   (United States)

Author keywords

Double walled microspheres; In vitro degradation; Poly(lactic acid); Polyanhydride

Indexed keywords

BIODEGRADATION; CHEMICAL BONDS; DIFFERENTIAL SCANNING CALORIMETRY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; HYDROLYSIS; MECHANICAL PROPERTIES; MELTING; SCANNING ELECTRON MICROSCOPY;

DOUBLE WALLED MICROSPHERES; POLYANHYDRIDE; POLYLACTIC ACID;

BIOPOLYMERS;

COPOLYMER; MICROSPHERE; POLYANHYDRIDE; POLYLACTIC ACID;

ARTICLE; DEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; GEL PERMEATION CHROMATOGRAPHY; HYDROLYSIS; INFRARED SPECTROSCOPY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY;

EID: 0032213806     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0142-9612(98)00108-2     Document Type: Article

References (9)

1. [1] Parrot EL. Pharmaceutical Technology. Minneapolis, MN: Burgess 1970.
2. [2] Nuwayser ES, Williams DL, Kerrigan JH, Nucefora WA, Armstrong JC, Microencapsulation of contraceptive steroids, In: Long-acting contraceptive delivery systems. Philadelphia, PA: Harper and Row, Publishers, 1984.
3. [3] Fanger GO, Vandergaer JE. Microencapsulation, processes and applications. Proc Am Chem Soc Symp 1973.
4. [4] Pekarek, KJ, Jacob JS, Mathiowitz E. Double-walled polymer microspheres for controlled drug release. Nature 1994;367:258-60.
5. [5] Pekarek KJ, Jacob JS, Mathiowitz E. One-step preparation of double-walled microspheres. Adv Mater 1994;6:684-7.
6. [6] Leach KJ, Noh K, Mathiowitz E. Effects of manufacturing conditions on the formation of double-walled polymer microspheres. J Microencapsulation, 1998, in press.
7. [7] Pekarek KJ, Jacob JS, Mathiowitz E. Effects of manufacturing conditions on double-walled microspheres. 21st Int Symp Controlled Release of Bioactive Materials, 1994;620-1.
8. [8] Pekarek KJ, Dyrud MJ, Ferrer K, Jong YS, Mathiowitz E. In vitro and in vivo degradation of double-walled polymer microspheres. J Controlled Release 1996;40:169-78.
9. [9] Leach KJ, Takahashi S, Degradation of double-walled polymer microspheres of PLLA and P (CPP: SA) 20:80 II. In vitro degradation, Biomaterials, in press.