The osteocalcin gene promoter provides a molecular blueprint for regulatory mechanisms controlling bone tissue formation: Role of transcription factors involved in development

Connective Tissue Research

Volumn 35, Issue 1-4, 1996, Pages 15-21

  Lian, Jane B ^a   Stein, Gary S ^a   Stein, Janet L ^a   Van Wijnen, André ^a   McCabe, Laura ^a   Banerjee, Chaitali ^a   Hoffmann, Heidi ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

AML I PEBP2 ; Bone specific gene expression; Fos Jun proteins; Homeodomain proteins; MSX 2

Indexed keywords

ANIMALIA;

EID: 0030436986     PISSN: 03008207     EISSN: None     Source Type: Journal    
DOI: 10.3109/03008209609029170     Document Type: Article

References (15)

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2. Stein, G. S. and Lian, J. B. (1993). Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype, Endocrine Reviews, 14, 424-442, and update (1995) Endocrine Reviews, 4, 290-297.
3. Montecino, M., Lian, J. B., Stein, G. S. and Stein, J. L. (1996). Changes in chromatin structure support constitutive and developmentally regulated transcription of the bone specific osteocalcin gene in osteoblastic cells, Biochemistry, 35, 5093-5102.
4. Hoffmann, H. M., Beumer, T., Rahman, S., McCabe, L. R. Banerjee, C., Aslam, F. Tiro, J. A., van Wijnen, A. J., Stein, J. L., Stein, G. S., and Lian, J. B. (1996). Tissue-specific transcription of the bone osteocalcin gene: Mutation of a single role of an activator osteoblast-specific complex and suppressor box protein in that hind the OC Box, J. Cell. Biochem. 61, 310-324.
5. Banerjee, C., Hiebert, S. W., Stein, J. L., Lian, J. B., and Stein, G. S. (1996) An AML-1 consensus sequence hinds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene, Proc. Natl. Acad. Sci. USA, 93, 4968-4973.
6. Hoffmann, H. M., Catron, K. M., van Wijnen, A. J., McCabe, L. R., Lian, J. B., Stein, G. S. and Stein. J. L. (1994). Transcriptional control of the tissue-specific developmentally regulated osteocalcin gene requires a binding motif for the MSX-family of homeodomain proteins, Proc. Natl. Acad. Sci. USA, 91, 12887-12891.
7. McCabe, L. R., Banerjee, C., Kundu, R., Harrison, R J., Dobner, P. R., Stein, J. L., Lian, J. B. and Stein, G. S. (1996). Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation: role of fra-2 and jun D during differentiation. Endocrinology, in press.
8. Banerjee, C., Stein, J. L., van Wijnen, A. J., Frenkel, B., Bravo, R., Lian, J. B. and Stein, G. S. (1996). TGF-β1 responsiveness of the rat osteocalcin gene is mediated by an AP-1 binding site, Endocrinology, 137, 1991-2000.
9. McCabe, L. R., Kockx, M., Lian, J. B., Stein, J. L. and Stein, G. S. (1995). Selective expression of FOS & JUN related genes during osteoblast proliferation and differentiation, Exp. Cell Res., 218, 255-262.
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13. Merriman, H. L., van Wijnen, A. J., Hiebert, S., Bidwell, J. P., Fey, E., Lian, J. B., Stein, J. L. and Stein, G. S. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/PEBP2/runt domain transcription factor family: interactions with the osteocalcin gene promoter, Biochemistry, 34, 13125-13132.
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