Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase

Critical Care Medicine

Volumn 33, Issue 5, 2005, Pages 1050-1056

  Qu, Xiao Wu ^a   Thaete, Larry G ^a   Rozenfeld, Ranna A ^a   Zhu, Yaqin ^a   De Plaen, Isabelle G ^a   Caplan, Michael S ^a   Hsueh, Wei ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Intestinal perfusion; Intestine; Nitric oxide synthase; Platelet activating factor; Shock; Tetrahydrobiopterin

Indexed keywords

7 NITROINDAZOLE; MICROSPHERE; MYELOPEROXIDASE; NITRIC OXIDE SYNTHASE; SEPIAPTERIN; TETRAHYDROBIOPTERIN; THROMBOCYTE ACTIVATING FACTOR;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; HEART PERFUSION; HEMATOCRIT; HYPOTENSION; ILEUM; INFLAMMATION; INTESTINE INJURY; INTESTINE NECROSIS; INTESTINE PERFUSION; KIDNEY PERFUSION; LUNG PERFUSION; MALE; MESENTERY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SPLANCHNIC BLOOD FLOW;

ANIMALS; ANTIOXIDANTS; BIOPTERIN; ENZYME INHIBITORS; INDAZOLES; INTESTINAL DISEASES; MALE; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PLATELET ACTIVATING FACTOR; PTERINS; RATS; RATS, SPRAGUE-DAWLEY; SPLANCHNIC CIRCULATION;

EID: 18344362540     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000162908.14887.36     Document Type: Article

References (44)

1. Alderton WK, Cooper CE, Knowles RG: Nitric oxide synthases: Structure, function and inhibition. Biochem J 2001; 357:593-615
2. Takahashi T: Pathophysiological significance of neuronal nitric oxide synthase in the gastrointestinal tract. J Gastroenterol 2003; 38:421-430
3. Kubes P, Granger DN: Nitric oxide modulates microvascular permeability. Am J Physiol 1992; 262:H611-H615
4. Kanwar S, Wallace JL, Befus D, et al: Nitric oxide synthesis inhibition increases epithelial permeability via mast cells. Am JPhysiol 1994; 266:G222-G229
5. Qu XW, Wang H, Rozenfeld RA, et al: Type I nitric oxide synthase (NOS) is the predominant NOS in rat small intestine: Regulation by platelet-activating factor. Biochim Biophys Acta 1999; 1451:211-217
6. Handley DA: Platelet-activating factor as a mediator of endotoxin-related diseases. In: Platelet Activating Factor in Endotoxin and Immune Diseases. Handley DA, Saunders RN, Houlihan WJ, et al (Eds). New York, Marcel Dekker, 1990
7. Hsueh W, Gonzalez Crussi F, Arroyave JL: Platelet-activating factor: An endogenous mediator for bowel necrosis in endotoxemia. FASEB J 1987; 1:403-405
8. Sun X, Hsueh W: Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor. J Clin Invest 1988; 81:1328-1331
9. Gonzalez-Crussi F, Hsueh W: Experimental model of ischemic bowel necrosis: The role of platelet-activating factor and endotoxin. Am J Pathol 1983; 112:127-135
10. Qu XW, Rozenfeld RA, Huang W, et al: Roles of nitric oxide synthases in platelet-activating factor-induced intestinal necrosis in rats. Crit Care Med 1999; 27:356-364
11. Buchwalow IB, Podzuweit T, Bocker W, et al: Vascular smooth muscle and nitric oxide synthase. FASEB J 2002; 16:500-508
12. Okada D: Tetrahydrobiopterin-dependent stabilization of neuronal nitric oxide synthase dimer reduces susceptibility to phosphorylation by protein kinase C in vitro. FEBS Lett 1998; 434:261-264
13. Reif A, Frohlich LG, Kotsonis P, et al: Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase. J Biol Chem 1999; 274:24921-24929
14. Noguchi T, Sagami I, Daff S, et al: Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase. Biochem Biophys Res Commun 2001; 282:1092-1097
15. Kotsonis P, Frohlich LG, Shutenko ZV, et al: Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide. Biochem J 2000; 346(Pt 3):767-776
16. Ishii M, Shimizu S, Nawata S, et al: Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats: Protective effect of tetrahydrobiopterin. Dig Dis Sci 2000; 45:93-98
17. Schulz JB, Matthews RT, Muqit MM, et al: Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J Neurochem 1995; 64:936-939
18. Manual for Using the Fluorescent Microsphere to Measure the Regional Organ Perfusion. Seattle, Fluorescent Microsphere Resource Center, University of Washington, Division of Pulmonary and Critical Medicine, 1999
19. Tuma RF, Vasthare US, Irion GL, et al: Considerations in use of microspheres for flow measurement in anesthetized rat. Am J Physiol 1986; 250:H137-H143
20. Thaete LG, Dewey ER, Neerhof MG: Endothelin and regulation of uterine and placental perfusion in hypoxia-induced fatal growth restriction. J Soc Gynecol Invest 2004; 11:14-21
21. Sun X, Qu XW, Huang W, et al: Role of leukocyte β2-integrin in PAF-induced shock and intestinal injury. Am J Physiol 1996; 270:G184-G190
22. Qu XW, Wang H, De Plaen IG, et al: Neuronal nitric oxide synthase (NOS) regulates the expression of inducible NOS in rat small intestine via modulation of nuclear factor kappa B. FASEB J 2001; 15:439-446
23. Cueva JP, Hsueh W: Role of oxygen derived free radicals in platelet activating factor induced bowel necrosis. Gut 1988; 29:1207-1212
24. Stamler JS, Meissner G: Physiology of nitric oxide in skeletal muscle. Physiol Rev 2001; 81:209-237
25. Barouch LA, Harrison RW, Skaf MW, et al: Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 2002; 416:337-339
26. Premaratne S, Xue C, McCarty JM, et al: Neuronal nitric oxide synthase: Expression in rat parietal Cells. Am J Physiol Gastrointest Liver Physiol 2001; 280:G308-G313
27. Ermert M, Ruppert C, Gunther A, et al: Cell-specific nitric oxide synthase-isoenzyme expression and regulation in response to endotoxin in intact rat lungs. Lab Invest 2002; 82:425-441
28. Rosenblum WI, Murata S: Antisense evidence for two functionally active forms of nitric oxide synthase in brain microvascular endothelium. Biochem Biophys Res Commun 1996; 224:535-543
29. Saur D, Paehge H, Schusdziarra V, et al: Distinct expression of splice variants of neuronal nitric oxide synthase in the human gastrointestinal tract. Gastroenterology 2000; 118:849-858
30. Huber A, Saur D, Kurjak M, et al: Characterization and splice variants of neuronal nitric oxide synthase in rat small intestine. Am J Physiol 1998; 275:G1146-G1156
31. Morishita T, Tsutsui M, Shimokawa H, et al: Vasculoprotective roles of neuronal nitric oxide synthase. FASEB J 2002; 16:1994-1996
32. Vasquez-Vivar J, Hogg N, Martasek P, et al: Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. J Biol Chem 1999; 274:26736-26742
33. Rosen GM, Tsai P, Weaver J, et al: The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide. J Biol Chem 2002; 277:40275-40280
34. Katusic ZS: Vascular endothelial dysfunction: Does tetrahydrobiopterin play a role? Am J Physiol Heart Circ Physiol 2001; 281:H981-H986
35. Sun H, Patel KP, Mayhan WG: Tetrahydrobiopterin, a cofactor for NOS, improves endothelial dysfunction during chronic alcohol consumption. Am J Physiol Heart Circ Physiol 2001; 281:H1863-H1869
36. Landmesser U, Dikalov S, Price SR, et al: Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 2003; 111:1201-1209
37. Qu X, Huang L, Burthart T, et al: Endotoxin induces PAF production in the rat ileum: Quantitation of tissue PAF by an improved method. Prostaglandins 1996; 51:249-262
38. Wang H, Tan X, Chang H, et al: Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. Biochem J 1997; 322:603-608
39. Zhang C, Hsueh W: PAF-induced bowel necrosis: Effects of vasodilators. Dig Dis Sci 1991; 36:634-640
40. Zimmerman GA, McIntyre TM, Prescott SM, et al: The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. Crit Care Med 2002; 30:S294-S301
41. Qu XW, Rozenfeld RA, Huang W, et al: The role of xanthine oxidase in platelet-activating factor induced intestinal injury in the rat. Gut 1999; 44:203-211
42. Laursen JB, Somers M, Kurz S, et al: Endothelial regulation of vasomotion in apoE-deficient mice: Implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 2001; 103:1282-1288
43. Xia Y, Dawson VL, Dawson TM, et al: Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Nat Acad Sci USA 1996; 93:6770-6774
44. Thony B, Auerbach G, Blau N: Tetrahydrobiopterin biosynthesis, regeneration and functions. Biochem J 2000; 347(Pt 1):1-16