Synthesis and structure-Activity relationships of M2-Selective muscarinic receptor ligands in the 1-[4-(4-Arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 5, 2002, Pages 795-798

  McCombie, Stuart W ^a   Lin, Sue Ing ^a   Tagat, Jayaram R ^a   Nazareno, Dennis ^a   Vice, Susan ^a   Ford, Jennifer ^a   Asberom, Theodros ^a   Leone, Daria ^a   Kozlowski, Joseph A ^a   Zhou, Guowei ^a   Ruperto, Vilma B ^a   Duffy, Ruth A ^a   Lachowicz, Jean E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYL DERIVATIVE; LIGAND; METHYL GROUP; MUSCARINIC M2 RECEPTOR ANTAGONIST; PIPERAZINE DERIVATIVE; RECEPTOR SUBTYPE;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; LIGANDS; MOLECULAR STRUCTURE; PIPERAZINES; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244398464     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00024-0     Document Type: Article

References (13)