Substituted 2-(R)-Methyl piperazines as muscarinic M2 selective ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 5, 2002, Pages 791-794

  Kozlowski, Joseph A ^a   Zhou, Guowei ^a   Tagat, Jayaram R ^a   Lin, Sue Ing ^a   McCombie, Stuart W ^a   Ruperto, Vilma B ^a   Duffy, Ruth A ^a   McQuade, Robert A ^a   Crosby Jr , Gordon ^a   Taylor, Lisa A ^a   Billard, William ^a   Binch III, Herbert ^a   Lachowicz, Jean E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; LIGAND; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR ANTAGONIST; PIPERAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; MICRODIALYSIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINE; ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; LIGANDS; MICRODIALYSIS; MOLECULAR STRUCTURE; PIPERAZINES; RATS; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC;

EID: 18244367176     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00023-9     Document Type: Article

References (17)