Cyclopamine as a potential therapeutic agent for treatment of tumors related to hedgehog pathway mutations

Dermatologic Surgery

Volumn 28, Issue 2, 2002, Pages 187-

  Miller, Stanley J ^a   Yu, Thomas C ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; CYCLOPAMINE; PLANT EXTRACT; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BASAL CELL CARCINOMA; CELL GROWTH; EMBRYO; EMBRYO DEVELOPMENT; GENE MUTATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN CARCINOMA; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL TRANSFORMATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; PHYTOTHERAPY; SKIN NEOPLASMS; TRANS-ACTIVATORS; VERATRUM; VERATRUM ALKALOIDS;

EID: 18244387256     PISSN: 10760512     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-4725.2002.01179.x     Document Type: Article

References (12)

1. More surprises in the hedgehog signaling pathway
2. Transducing the hedgehog signal
3. Human homolog of patched, a candidate gene for the basal cell nevus syndrome
4. Ultraviolet radiation mutagenesis of hedgehog pathway genes in basal cell carcinoma
5. Developmental genes and cancer: Role of patched in basal cell carcinoma of the skin
6. Activating smoothened mutations in sporadic basal cell carcinoma
7. The sebaceous nevus: A nevus with deletions of the PTCH gene
8. Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: Support for a gatekeeper mechanism in skin tumorigenesis
9. The patched signaling pathway in tumorigenesis and development: Lessons from animal models
10. Basal cell carcinoma-like epidermal changes overlying dermatofibromas often reveal loss of hererozygosity in the PTCH gene
11. The teratogenic veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transcluction
12. Effects of oncongenic mutations in smoothened and patched can be reversed by cyclopamine