Hepatic progenitors and strategies for liver cell therapies

Annals of the New York Academy of Sciences

Volumn 944, Issue , 2001, Pages 398-419

  Susick, R ^a   Moss, N ^b   Kubota, H ^b   Lecluyse, E ^c   Hamilton, G ^c   Luntz, T ^b   Ludlow, J ^a   Fair, J ^b   Gerber, D ^b   Bergstrand, K ^a   White, J ^a   Bruce, A ^a   Drury, O ^a   Gupta, S ^d   Reid, L M ^b  

^a Building 4401 ^*  (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c University of North Carolina   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Hepatic progenitors; Liver; Liver cell therapies; Liver transplantation; Stem cells

Indexed keywords

ANTIGENICITY; CELL DIFFERENTIATION; CONFERENCE PAPER; CRYOPRESERVATION; EMBRYO DEVELOPMENT; HUMAN; HUMAN CELL; IMMUNOGENICITY; LIVER CELL; LIVER DEVELOPMENT; LIVER DYSFUNCTION; LIVER REGENERATION; LIVER TRANSPLANTATION; PURIFICATION; STEM CELL; STEM CELL TRANSPLANTATION;

EID: 18244382349     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03851.x     Document Type: Conference Paper

References (120)

1. Transplantation in the elderly patient
2. Hepatic re-transplantation: University of Nebraska Medical Center experience
3. Orthotopic homotransplantation of the human liver
4. Homotransplantation of the liver
5. Liver transplantation at the University of Pittsburgh from 1984 to 1990
6. Liver transplantation for metabolic liver diseases
7. Liver transplantation for chronic hepatitis
8. Regulatory mechanisms in stem cell biology
9. Liver stem cells
10. The effect of cells transferred into the mouse blastocyst on subsequent development
11. Normal genetically mosaic mice produced from malignant teratocarcinoma cells
12. Bone marrow as a potential source of hepatic oval cells
13. Liver from bone marrow in humans
14. Purified hemopoietic stem cells can differentiate into hepatocytes in vivo
15. Multilineage potential of adult human mesenchymal stem cells
16. Embryonic stem cell lines derived from human blastocysts
17. Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types
18. Nkx-2.5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants
19. Careful maintenance of undifferentiated mouse embryonic stem cells is necessary for their capacity to differentiate to hematopoietic lineages in vitro
20. Long-term proliferation of mouse primordial germ cells in culture
21. Effects of cryopreservation on subsets of fetal liver cells
22. Neuronal stem cells: Their characterization and utilization
23. Mesenchymal stem cells: Biology and potential uses
24. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells
25. A new approach to the cryopreservation of hepatocytes in a sandwich culture configuration
26. Influence of alginate gel entrapment and cryopreservation on survival and xenobiotic metabolism capacity of rat hepatocytes
27. Studies of long-term cryopreservation of hepatocytes and their transplantation treating acute hepatic failure in Wistar rats
28. Cryopreservation of rat and mouse hepatocytes. I. Comparative viability studies
29. Growth potential and differentiation capacity of adult rat hepatocytes in vitro
30. Growth and maturation of small hepatocytes isolated from adult rat liver
31. Hepatocyte proliferation in vitro: Its dependence on the use of serum-free hormonally defined medium and substrata of extracellular matrix
32. Ex vivo maintenance of differentiated mammalian cells
33. Culturing hepatocytes and other differentiated cells
34. Influence of extracellular matrix composition and medium formulation on the induction of cytochrome P450 2B enzymes in primary cultures of rat hepatocytes
35. Induction of cytochrome P450 enzymes in primary cultures of human hepatocytes
36. Research with human embryonic stem cells: Ethical considerations
37. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
38. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical cord blood from an HLA-identical sibling
39. c-kit(< low) pluripotent hemopoietic stem cells form CFU-S on day 16
40. Biology of the hemopoietic microenvironment
41. Identifying and manipulating neuronal stem cells
42. Neuronal stem cells in the brain of adult vertebrates
43. Transplantation of cultures of human fetal pancreatic islet cells to diabetes mellitus patients
44. Survival of fetal porcine pancreatic islet tissue transplanted to a diabetic patient
45. The liver as a stem cell and lineage system
46. Liver stem cells and lineage biology
47. Hepatic progenitor populations in embryonic, neonatal, and adult liver
48. Extracellular matrix regulation of growth and gene expression in liver cell lineages and hepatomas
49. Expansion conditions for early hepatic progenitor cells from embryonal and neonatal rat livers
50. Evidence for a terminal differentiation process in the rat liver
51. Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events
52. Hepatocyte polyploidy and metabolism/life-history traits: Hypotheses testing
53. Binucleation and polyploidization patterns in developmental and regenerative rat liver growth
54. Ploidy-dependent growth and binucleation in cultured rat hepatocytes
55. Changes in ploidy distributions in human liver carcinogenesis
56. Hepatocyte polyploidization in chronic liver diseases in man
57. Human hepatocyte polyploidization kinetics in the course of life cycle
58. Role of cholangioles in restoration of the liver of the mouse after dietary injury
59. Liver stem cells
60. The canals of hering and hepatic stem cells in humans
61. The extracellular matrix in hepatic regeneration. Localization of collagen types I, III, IV, laminin, and fibronectin
62. Morphology, localization, and origin of the hepatic extracellular matrix
63. Molecular cloning of the major cell surface heparan sulfate proteoglycan from rat liver
64. Cell adhesion molecules in liver function and pattern formation
65. Extracellular matrix gradients in the space of Disse: Relevance to liver biology
66. Physiologic significance and regulation of hepatocellular heterogeneity
67. Metabolic zonation of the liver: Regulation and implications for liver function
68. The streaming liver. II. Hepatocyte life history
69. Streaming liver. VIII: Cell production rates following partial hepatectomy
70. Characterization and enrichment of fetal rat hepatoblasts by immunoadsorption ("panning") and fluorescence-activated cell sorting
71. Maturation-dependent changes in the regulation of liver-specific gene expression in embryonal versus adult primary liver cultures
72. Clonogenic hepatoblasts, common precursors for hepatocytic and biliary lineages, are lacking classical major histocompatiblity complex class I antigen
73. Effect of flow configuration and membrane characteristics on membrane fouling in a novel multi-coaxial hollow fiber bioartificial liver
74. A novel multi-coaxial tubular bioreactor for adherent cell types. Part 1: Hydrodynamic studies
75. Biodegradable microcarriers for use with progenitor cells
76. Connective tissue biomatrix: Its isolation and utilization for long-term cultures of normal rat hepatocytes
77. Posttranscriptional modulation of gene expression in cultured rat hepatocytes
78. Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures
79. Transcriptional and posttranscriptional control of connexin mRNAs in periportal and pericentral rat hepatocytes
80. Phenotypic characterization of rat hepatoma cell lines and lineage-specific regulation of gene expression by differentiation agents
81. Heterogeneity of growth potential of adult rat hepatocytes in vitro
82. Rat liver epithelial cultures in a serum-free medium: Primary cultures and derived cell lines expressing differentiated functions
83. The growth of liver parenchymal nuclei and its endocrine regulation
84. Cell lineages in hepatic development and the identification of progenitor cells in normal and injured liver
85. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes
86. Transplanted hepatocytes proliferate differently after CCI4 treatment and hepatocyte growth factor infusion
87. Integration and proliferation of transplanted cells in hepatic parenchyma following D-galactosamine-induced acute injury in F344 rats
88. Complete reconstitution of mouse liver with xenogeneic hepatocytes
89. Replacement of diseased mouse liver by hepatic cell transplantation
90. The repopulation potential of hepatocyte populations differing in size and prior mitotic expansion
91. Demonstration of differentiation in hepatocyte progenitor cells using dipeptidyl peptidase IV deficient mutant rats
92. Proliferation and differentiation of fetal liver epithelial progenitor cells after transplantation in adult rat liver
93. Long-term, near total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine
94. Transplanted hepatocytes engraft, survive, and proliferate in the liver of rats with carbon tetrachloride-induced cirrhosis
95. Hepatocyte transplantation in patients with liver cirrhosis
96. Hepatocyte transplantation in acute liver failure
97. Rat liver stem cells: Prospects for the future
98. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I
99. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene
100. Hepatocyte transplantation in a model of toxin-induced liver disease: Variable therapeutic effect during replacement of damaged parenchyma by donor adult liver cells
101. Small cell colonies appear in the primary culture of adult rat hepatocytes in the presence of nicotinamide and epidermal growth factor
102. Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium
103. Liver repopulation with hepatocyte transplantation: New avenues for gene and cell therapy
104. Transplantation of human hepatocytes
105. Hepatocyte transplantation for the treatment of human disease
106. Hepatocyte transplantation. Possibilities for use and examples of practical clinical application
107. Human hepatocyte transplantation: Gene therapy and more?
108. Treatment of the Crigler-Najjar Syndrome Type I with hepatocyte transplantation
109. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure