Preclinical pharmacology of fiduxosin, a novel α1-adrenoceptor antagonist with uroselective properties

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 2, 2002, Pages 478-486

  Hancock, Arthur A ^a   Buckner, Steven A ^a   Brune, Michael E ^a   Esbenshade, Timothy A ^a   Ireland, Lynne M ^a   Katwala, Sweta ^a   Milicic, Ivan ^a   Meyer, Michael D ^a   Kerwin Jr , James F ^a   Williams, Michael ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; FIDUXOSIN; UNCLASSIFIED DRUG;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOASSAY; BLOOD PRESSURE MONITORING; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HYPOTENSION; LIGAND BINDING; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; URETHRA PRESSURE; VAS DEFERENS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BLOOD PRESSURE; DOGS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MALE; MICE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; PROSTATIC HYPERPLASIA; PYRIMIDINONES; RABBITS; RADIOLIGAND ASSAY; RATS; RATS, INBRED SHR; RECEPTORS, ADRENERGIC, ALPHA-1; URETHRA; URINARY TRACT; URODYNAMICS; VAS DEFERENS;

EID: 18244378285     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.2.478     Document Type: Article

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