Supplementation with vitamin E but not with vitamin C lowers lipid peroxidation in vivo in mildly hypercholesterolemic men

Free Radical Research

Volumn 35, Issue 6, 2001, Pages 967-978

  Kaikkonen, Jari ^a   Porkkala Sarataho, Elina ^b   Morrow, Jason D ^c   Roberts, L Jackson ^c   Nyyssönen, Kristiina ^b   Salonen, Riitta ^b   Tuomainen, Tomi Pekka ^b   Ristonmaa, Ulla ^b   Poulsen, Henrik E ^d   Salonen, Jukka T ^d,e  

^a Oy Jurilab Ltd   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c VANDERBILT UNIVERSITY   (United States)

^d Rigshospitalet   (Denmark)

^e Inner Savo Health Centre   (Finland)

Author keywords

Antioxidants; Clinical trials; F2 isoprostane; Lipid peroxidation; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BIOLOGICAL MARKER; CELLAVIE; ISOPROSTANE DERIVATIVE; PLACEBO;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE; CLINICAL OBSERVATION; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE COURSE; DISEASE SEVERITY; DRUG FORMULATION; FEMALE; HEART INFARCTION; HUMAN; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; LIPID BLOOD LEVEL; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; MALE; MEASUREMENT;

EID: 18244373495     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760100301461     Document Type: Article

References (70)

1. "Vitamin E consumption and the risk of coronary heart disease in men"
2. "Vitamin E consumption and risk of coronary disease in women"
3. "Vitamin C intake and mortality among a sample of the United States population"
4. "Epidemiological studies on LDL oxidation, pro- and antioxidants and atherosclerosis"
5. "Vitamin C, lipid peroxidation, and the risk of myocardial infarction: Epidemiological evidence from eastern Finland"
6. "Vitamin C deficiency and risk of myocardial infarction: Prospective population study of men from eastern Finland"
7. "Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)"
8. "Low-dose aspirin and vitamin E in people at cardiovascular risk: A randomized trial in general practice"
9. "Vitamin E supplementation and cardiovascular events in high-risk patients"
10. "Antioxidants and atherosclerotic heart disease"
11. "Ascorbate is an outstanding antioxidant in human blood plasma"
12. "Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage"
13. "Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification"
14. "Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification"
15. "Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation"
16. "Effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low density lipoprotein"
17. "Supplementation with vitamin E but not β-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Effect of cigarette smoking"
18. "Comparison of supplementation of RRR-alpha-tocopherol and racemic alpha-tocopherol in humans. Effects on lipid levels and lipoprotein susceptibility to oxidation"
19. "Effect of alpha-tocopherol supplementation on LDL oxidation: Dose-response study"
20. "Supplementation with low doses of vitamin E protects LDL from lipid peroxidation in men and women"
21. "Effect of ascorbate supplementation on low density lipoprotein oxidation in smokers"
22. "Effect of vitamin C and E supplementation on susceptibility of plasma lipoproteins to peroxidation induced by acute smoking"
23. "Dietary Supplementation with vitamins C and E inhibits in vitro oxidation of lipoproteins"
24. "Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation"
25. "Ascorbic acid enhances 17 beta-estradiol-mediated inhibition of oxidized low density lipoprotein formation"
26. "Vitamin C prevents the acute atherogenic effects of passive smoking"
27. "Modulation of oxidant stress in vivo in chronic cigarette smokers"
28. "Vitamin C prevents cigarette smoke-induced oxidative damage in vivo"
29. "Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2′-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men"
30. 2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism"
31. 2-isoprostanes) in smokers. Smoking as a cause of oxidative damage"
32. "Generation and actions of isoprostanes"
33. "The isoprostanes: Unique bioactive products of lipid peroxidation"
34. "Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: A randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis"
35. "Increase in oxidation resistance of atherogenic serum lipoproteins following antioxidant supplementation: A randomized double-blind placebo-controlled clinical trial"
36. "Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men"
37. 2-isoprostanes in biological fluids and tissues as measure of oxidant stress"
38. "Quantitative estimation of dehydroascorbic acid and ascorbic acid by high-performance liquid chromatography-application to human milk, plasma, and leucocytes"
39. "Kuopio Atherosclerosis Prevention Study (KAPS). A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries"
40. "Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: A four year follow up study in men"
41. "Food-based dietary guidelines for Finland-a staged approach"
42. "The 1997 dietary survey of Finnish adults"
43. 2-isoprostanes as an index of lipid peroxidation does not appear to be confounded by diet"
44. "Reduction of urinary 8-epi-prostaglandin F2 alpha during cyclo-oxygenase inhibition in rats but not in man"
45. 2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro"
46. 2-isoprostanes during oxidation of human low-density lipoprotein and plasma by peroxynitrite"
47. 2-isoprostanes, are present in increased amounts in human atherosclerotic lesions"
48. 2-isoprostanes in human atherosclerotic lesions"
49. "Enhanced coronary vasoconstriction to oxidative stress product, 8-epi-prostaglandin F2alpha, in experimental hypercholesterolemia"
50. 2-isoprostane 8-epiprostaglandin F2alpha increases platelet adhesion and reduces the antiadhesive and antiaggregatory effects of NO"
51. "Increased plasma, serum and urinary 8-epi-prostaglandin F2alpha in heterozygous hypercholesterolemia"
52. "Isoprostanes in atherosclerosis"
53. "Smoking and oxidant stress: Assay of isoprostane in human urine by gas chromatography-mass spectrometry"
54. "Quitting cigarette smoking results in a fast improvement of in vivo oxidation injury (determined via plasma, serum and urinary isoprostane)"
55. "Enhanced lipid peroxidation in hepatic cirrhosis"
56. "Lipid peroxidation as determined by plasma isoprostanes is related to disease severity in mild asthma"
57. "Increased formation of the isoprostanes IPF2alpha-I and 8-epi-prostaglandin F2alpha in acute coronary angioplasty: Evidence for oxidant stress during coronary reperfusion in humans"
58. "Markers of oxidative damage and antioxidant protection: Assessment of LDL oxidation"
59. "Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice"
60. 2-isoprostane evidence of oxidant stress in the insulin resistant, obese Zucker rat: Effects of vitamin E"
61. "In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia"
62. "Effects of vitamin E on lipid peroxidation in healthy persons"
63. "Direct observation of a free radical interaction between vitamin E and vitamin C"
64. "Oral vitamin C reduces arterial stiffness and platelet aggregation in humans"
65. "Interaction of ascorbate and alpha-tocopherol in resealed human erythrocyte ghosts. Transmembrane electron transfer and protection from lipid peroxidation"
66. "Requirement for promotion, or inhibition by alpha-tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation"
67. "Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/-mineral combinations, cancer incidence, and disease-specific mortality in the general population"
68. "Ascorbic acid and oxidative inactivation of proteins"
69. "Cosupplementation with coenzyme Q prevents the prooxidant effect of α-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation"
70. "The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers"