Effects of M2 antagonists on in vivo hippocampal acetylcholine levels

Brain Research Bulletin

Volumn 41, Issue 4, 1996, Pages 221-226

  Stillman, Michael J ^a,d   Shukitt Hale, Barbara ^a   Galli, Rachel L ^c   Levy, Aharon ^b   Lieberman, Harris R ^c  

^a SCIENCE APPLICATIONS INTERNATIONAL CORPORATION   (United States)

^b ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

^c U States Army Res Inst EM   (United States)

^d Project House Inc   (United States)

Author keywords

Choline; Cholinergic System; HPLC EC; Microdialysis; Muscarinic; Presynaptic Receptor

Indexed keywords

11 [[4 [4 (DIETHYLAMINO)BUTYL] 1 PIPERIDYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; ACETYLCHOLINE; CHOLINE; METHOCTRAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR ANTAGONIST; N [2 [2 (DIPROPYLAMINOMETHYL) 1 PIPERIDYL]ETHYL] 5,11 DIHYDRO 6 OXO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPINE 11 CARBOXAMIDE; OTENZEPAD; MUSCARINIC RECEPTOR BLOCKING AGENT;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DOSE RESPONSE; HIPPOCAMPUS; INTRACEREBRAL DRUG ADMINISTRATION; MALE; MEMORY; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD BRAIN BARRIER; DRUG EFFECT; ELECTROCHEMISTRY; EXTRACELLULAR SPACE; FISCHER 344 RAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; STEREOTAXIC SURGERY;

ACETYLCHOLINE; ANIMALS; BLOOD-BRAIN BARRIER; CHOLINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROCHEMISTRY; EXTRACELLULAR SPACE; HIPPOCAMPUS; MALE; MICRODIALYSIS; MUSCARINIC ANTAGONISTS; RATS; RATS, INBRED F344; STEREOTAXIC TECHNIQUES;

EID: 0029658182     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(96)00180-3     Document Type: Article

References (33)

1. 1. Aubert, I.; Rowe, W.; Meaney, M. J.; Gauthier, S.; Quirion, R. Cholinergic markers in aged cognitively impaired Long-Evans rats. Neurosci. 67:277-292; 1995.
2. 2. Bartus, R. T.; Dean, R. L., III; Beer, B.; Lippa, A. S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-417; 1982.
3. 3. Bartus, R. T.; Dean, R. L., III; Flicker, C. Cholinergic psychopharmacology: An integration of human and animal research on memory. In: Meltzer, H. Y., ed. Psychopharmacology: the third generation of progress. New York: Raven; 1987:219-232.
4. 4. Bhattacharya, S. K.; Sen, A. P. Effects of muscarinic receptor agonists and antagonists on rat brain serotonergic activity. J. Neural Trans. 90:241-247; 1992.
5. 1 cholinergic agonist, AF102B. Pharmacol. Biochem. Behav. 36:89-95; 1990.
6. 6. Brann, M.; Klimkowski, V.; Ellis, J. Structure/function relationships of muscarinic acetylcholine receptors. In: Levine, R., ed. Proceedings: Subtypes of muscarinic receptors V. Life Sci. 52:405-412;1993.
7. 7. Consolo, S.; Ladinsky, H.; Vinci, R.; Palazzi, E.; Wang, J. An in vivo pharmacological study on muscarinic receptor subtypes regulating cholinergic neurotransmission in rat striatum. Biochem. Pharmacol. 36:3075-3077; 1987.
8. 8. Damsma, G.; Westerink, B. H. C.; de Vries, J. B.; Van den Berg, C. J.; Horn, A. S. Measurement of acetylcholine release in freely moving rats by means of automated intracerebral dialysis. J. Neurochem. 48:1523-1528; 1987.
9. 9. Day, J.; Damsma, G.; Fibiger, H. C. Cholinergic activity in the rat hippocampus, cortex and striatum correlates with locomotor activity: An in vivo microdialysis study. Pharmacol. Biochem. Behav. 38:723-729; 1991.
10. 2 antagonists: novel structures and pharmacology. Life Sci. 52:497-503; 1993.
11. 11. Dorje, F.; Wess, J.; Lambrecht, G.; Tacke, R.; Mutschler, E.; Brann, M. R. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J. Pharmacol. Experimental Therapeutics 256:727-733; 1991.
12. 12. Eberlein, W. G.; Engel, W.; Mihm, G.; Rudolf, K.; Wetzel, B.; Entzeroth. M.; Mayer, N.; Doods, H. N. Structure-activity relationships and pharmacological profile of selective tricyclic antimuscarinics. Trends Pharmacol. Sci. 10(Suppl):50-54; 1989.
13. 1 agonist attenuates cognitive dysfunctions in AF64A-treated rats. Neurosci. Lett. 102:325-331; 1989.
14. 14. Hoss, W.; Messer, W. S., Jr.; Monsma, F. J., Jr.; Miller, M. D.; Ellerbrock, B. R.; Scranton, T.; Ghodsi-Hovsepian, S.; Price, M. A.; Balan, S.; Mazloum, Z.; Bohnett, M. Biochemical and behavioral evidence for muscarinic autoreceptors in the CNS. Brain Res. 517:195-201; 1990.
15. 15. Knapp, S.; Wardlow, M. L.; Albert, K.; Waters, D.; Thal, L. J. Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects. Drug Metabolism Disposition 19:400-404; 1991.
16. 16. Koshimura, K.; Miwa, S.; Lee, K.; Hayashi, Y.; Hasegawa, H.; Hamahata, K.; Fujiwara, M.; Kimura, M.; Itokawa, Y. Effects of choline administration on in vivo release and biosynthesis of acetylcholine in the rat striatum as studied by in vivo brain microdialysis. J. Neurochem. 54:533-539; 1990.
17. 3H]AF-DX 116 and effect of AF-DX 116 on endogenous acetylcholine release from rat brain slices. Brain Res. 496:285-294; 1989.
18. 18. Levy, A.; Brandeis, R.; Treves, T. A.; Meshulam, Y.; Mawassi, F.; Feiler, D.; Wengier, A.; Glikfeld, P.; Grunwald, J.; Dachir, S.; Rabey, J. M.; Levy, D.; Korczyn A. D. Transdermal physostigmine in the treatment of Alzheimer's disease. Alzheimer Disease Associated Disorders 8:15-21; 1994.
19. 19. Lynch, G.; Baudry, M. The biochemistry of memory: A new and specific hypothesis. Science 224:1057-1063; 1984.
20. 2 muscarinic receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. Science 228:1115-1117; 1985.
21. 21. Milusheva, E.; Baranyi, M.; Zelles, T.; Mike, A.; Vizi, E. S. Release of acetylcholine and noradrenaline from the cholinergic and adrenergic afferents in rat hippocampal CA1, CA3, and dentate gyrus regions. Eur. J. Neurosci. 6:187-192; 1994.
22. 2 receptors mediate depolarization and presynaptic inhibition in guinea pig enteric nervous system. J. Physiol. 368:435-452; 1985.
23. 2 receptor antagonist AF-DX 116 improves memory. Brain Res. 524:72-76; 1990.
24. 24. Paxinos, G.; Watson, C. The rat brain in stereotaxic coordinates, 2nd ed. Orlando: Academic; 1986.
25. 25. Quirion, R.; Richard, J.; Wilson, A. Muscarinic and nicotinic modulation of cortical acetylcholine release monitored by in vivo microdialysis in freely moving adult rats. Synapse 17:92-100; 1994.
26. 2-muscarinic receptor antagonist in aged memory-impaired rats. J. Neurosci. 15:1455-1462; 1995.
27. 27. Raiteri, M.; Leardi, R.; Marchi, M. Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain. J. Pharmacol. Experimental Therapeutics 228:209-214; 1984.
28. 28. Shukitt-Hale, B.; Stillman, M. J.; Levy, A.; Devine, J. A.; Lieberman, H. R. Nimodipine prevents the in vivo decrease in hippocampal extracellular acetylcholine produced by hypobaric hypoxia. Brain Res. 621:291-295; 1993.
29. 29. Stillman, M. J.; Shukitt-Hale, B.; Kong, R. M.; Levy, A.; Lieberman, H. R. Elevation of hippocampal acetylcholine dialysate levels by methoctramine. Brain Res. Bull. 32:385-389; 1993.
30. 30. Thai, L. J.; Fuld, P. A.; Masur, D. M.; Sharpless, N. S. Oral physostigmine and lecithin improve memory in Alzheimer's disease. Ann Neurology 13:492-496; 1983.
31. 31. Torocsik, A.; Vizi, E. S. Presynaptic effects of methoctramine on release of acetylcholine. Neuropharmacol. 30:293-298; 1991.
32. 32. Vizi, E. S.; Kobayashi, O.; Torocsik, A.; Kinjo, M.; Nagashima, H.; Manabe, N.; Goldiner, P. L.; Potter, P. E.; Foldes, F. F. Heterogeneity of presynaptic muscarinic receptors involved in modulation of transmitter release. Neurosci. 31:259-267; 1989.
33. 2 receptor antagonist, BIBN-99, on acetylcholine release in aged rats and spatial memory performance in scopolamine treated rats. Soc. Neurosci. Abstracts 19:1813; 1993.