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Volumn 6, Issue 5, 2005, Pages 518-525

CC-10004 Celgene

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; CATECHOL DERIVATIVE; CC 10004; CILOMILAST; ETANERCEPT; INDOMETACIN; INTERLEUKIN 10; ISOINDOLE DERIVATIVE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROFLUMILAST; ROLIPRAM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; ZARDAVERINE; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYTOKINE; PHOSPHODIESTERASE INHIBITOR;

EID: 18144409148     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (12)

References (39)
  • 1
    • 0024335561 scopus 로고
    • Inhibition of cyclic adenosine-3′,5′-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues
    • 30729
    • 30729 Inhibition of cyclic adenosine-3′,5′-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues. Marivet MC, Bourguignon JJ, Lugnier C, Mann A, Stoclet JC, Wermuth CG J MED CHEM 1989 32 7 1450-1457
    • (1989) J. Med. Chem. , vol.32 , Issue.7 , pp. 1450-1457
    • Marivet, M.C.1    Bourguignon, J.J.2    Lugnier, C.3    Mann, A.4    Stoclet, J.C.5    Wermuth, C.G.6
  • 2
    • 0029784855 scopus 로고    scopus 로고
    • Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity
    • 218883
    • 218883 Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity. Muller GW, Corral LG, Shire MG, Wang H, Moreira A, Kaplan G, Stirling DI J MED CHEM 1996 39 17 3238-3240
    • (1996) J. Med. Chem. , vol.39 , Issue.17 , pp. 3238-3240
    • Muller, G.W.1    Corral, L.G.2    Shire, M.G.3    Wang, H.4    Moreira, A.5    Kaplan, G.6    Stirling, D.I.7
  • 4
    • 0031104328 scopus 로고    scopus 로고
    • PDE4 inhibitors: The use of molecular cloning in the design and development of novel drugs
    • 276922
    • 276922 PDE4 inhibitors: The use of molecular cloning in the design and development of novel drugs. Hughes B, Owens R, Perry M, Warrellow G, Allen R DRUG DISCOV TODAY 1997 2 3 89-101
    • (1997) Drug Discov. Today , vol.2 , Issue.3 , pp. 89-101
    • Hughes, B.1    Owens, R.2    Perry, M.3    Warrellow, G.4    Allen, R.5
  • 5
    • 0028843980 scopus 로고
    • Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-α and IL-6 release by endotoxin-stimulated macrophages
    • 282364
    • 282364 Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-α and IL-6 release by endotoxin-stimulated macrophages. Kambayashi T, Jacob CO, Zhou D, Mazurek N, Fong M, Strassmann G J IMMUNOL 1995 155 10 4909-4916
    • (1995) J. Immunol. , vol.155 , Issue.10 , pp. 4909-4916
    • Kambayashi, T.1    Jacob, C.O.2    Zhou, D.3    Mazurek, N.4    Fong, M.5    Strassmann, G.6
  • 9
    • 0035084103 scopus 로고    scopus 로고
    • Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro
    • 402539
    • 402539 Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. Hatzelmann A, Schudt C J PHARMACOL EXP THER 2001 297 1 267-279
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , Issue.1 , pp. 267-279
    • Hatzelmann, A.1    Schudt, C.2
  • 10
    • 0035078823 scopus 로고    scopus 로고
    • In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor
    • 412899
    • 412899 In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor. Bunduschuh DS, Eltze M, Barsig J, Wollin L, Hatzemann A, Beume R J PHARMACOL EXP THER 2001 297 1 280-290
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , Issue.1 , pp. 280-290
    • Bunduschuh, D.S.1    Eltze, M.2    Barsig, J.3    Wollin, L.4    Hatzemann, A.5    Beume, R.6
  • 11
    • 0035797371 scopus 로고    scopus 로고
    • Novel selective PDE4 inhibitors. 1. Synthesis, structure-activity relationships, and molecular modeling of 4(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones and analogues
    • 417412
    • 417412 Novel selective PDE4 inhibitors. 1. Synthesis, structure-activity relationships, and molecular modeling of 4(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones and analogues. Van der May M, Hatzelmann A, Van der Laan IJ, Stork GJ, Thibaut U, Timmerman H J MED CHEM 2001 44 16 2511-2522
    • (2001) J. Med. Chem. , vol.44 , Issue.16 , pp. 2511-2522
    • Van der May, M.1    Hatzelmann, A.2    Van der Laan, I.J.3    Stork, G.J.4    Thibaut, U.5    Timmerman, H.6
  • 12
    • 0035797365 scopus 로고    scopus 로고
    • Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones
    • 417497
    • 417497 Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones. Van der Mey M, Hatzelmann A, Van Klink GP, Van der Laan IJ, Sterk GJ, Thibaut U, Ulrich WR, Timmerman H J MED CHEM 2001 44 16 2523-2535
    • (2001) J. Med. Chem. , vol.44 , Issue.16 , pp. 2523-2535
    • Van der Mey, M.1    Hatzelmann, A.2    Van Klink, G.P.3    Van der Laan, I.J.4    Sterk, G.J.5    Thibaut, U.6    Ulrich, W.R.7    Timmerman, H.8
  • 13
    • 0036265607 scopus 로고    scopus 로고
    • Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs
    • 480517
    • 480517 Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs. Burnouf C, Pruniaux MP CURR PHARM DES 2002 8 14 1255-1296
    • (2002) Curr. Pharm. Des. , vol.8 , Issue.14 , pp. 1255-1296
    • Burnouf, C.1    Pruniaux, M.P.2
  • 14
    • 18144417379 scopus 로고    scopus 로고
    • Asthma Therapeutics - SMi Conference
    • 488687 London, UK. IDDB MEETING REPORT April 31 - May 01
    • 488687 Asthma Therapeutics - SMi Conference, London, UK. Lunec A IDDB MEETING REPORT 2003 April 31 - May 01
    • (2003)
    • Lunec, A.1
  • 15
    • 18144387864 scopus 로고    scopus 로고
    • The effects of thalidomide analogues on VEGF and IL-6 production in myeloma and endothelial cell cocultures
    • 497891 Abs P1226
    • 497891 The effects of thalidomide analogues on VEGF and IL-6 production in myeloma and endothelial cell cocultures. Molostvov G, Morris A, Rose P, Basu S J THROMB HEMOST 2003 1 Suppl 1 Abs P1226
    • (2003) J. Thromb. Hemost. , vol.1 , Issue.SUPPL. 1
    • Molostvov, G.1    Morris, A.2    Rose, P.3    Basu, S.4
  • 16
    • 18144368816 scopus 로고    scopus 로고
    • Novel anti-inflammatory compounds based on the biology of thalidomide; Small molecule, oral TNFα inhibitors
    • 509655 October 15-16
    • 509655 Novel anti-inflammatory compounds based on the biology of thalidomide; Small molecule, oral TNFα inhibitors. Stirling D SMI CONF - ANTIINFLAMM THER 2003 October 15-16
    • (2003) SMI Conf. - Antiinflamm. Ther.
    • Stirling, D.1
  • 17
    • 12444292790 scopus 로고    scopus 로고
    • Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: Structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gone potassium channel binding affinity
    • 513310
    • 513310 Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: Structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gone potassium channel binding affinity. Friesen RW, Ducharme Y, Ball RG, Blouin M, Boulet L, Cote B, Frenette R, Girard M, Guay D, Huang Z, Jones TR et al J MED CHEM 2003 46 12 2413-2426.
    • (2003) J. Med. Chem. , vol.46 , Issue.12 , pp. 2413-2426
    • Friesen, R.W.1    Ducharme, Y.2    Ball, R.G.3    Blouin, M.4    Boulet, L.5    Cote, B.6    Frenette, R.7    Girard, M.8    Guay, D.9    Huang, Z.10    Jones, T.R.11
  • 18
    • 18144409360 scopus 로고    scopus 로고
    • CC-10004: A novel PDE4 inhibitor with an improved therapeutic index
    • 527734 March 10-11
    • 527734 CC-10004: A novel PDE4 inhibitor with an improved therapeutic index. Schafer P SMI CONF CHRON OBSTRUCT PULM DISORDERS 2004 March 10-11
    • (2004) SMI Conf. Chron. Obstruct. Pulm. Disorders
    • Schafer, P.1
  • 19
    • 18144430147 scopus 로고    scopus 로고
    • A trivalent bispecific fusion protein engineered from antibody variable domains for improved pretargeting of CEA-expressing cancers
    • 531072 Abs 1019
    • 531072 A trivalent bispecific fusion protein engineered from antibody variable domains for improved pretargeting of CEA-expressing cancers. Edmund A, Rossi SK, Saha RM, Sharkey HK, Horak ID, Goldenberg DM, Chang CH PROC AM ASSOC CANCER RES 2004 95 Abs 1019
    • (2004) Proc. Am. Assoc. Cancer Res. , vol.95
    • Edmund, A.1    Rossi, S.K.2    Saha, R.M.3    Sharkey, H.K.4    Horak, I.D.5    Goldenberg, D.M.6    Chang, C.H.7
  • 20
    • 18144374084 scopus 로고    scopus 로고
    • Novel anti-angiogenic agents; mutiple shots on goal
    • 535903 April
    • 535903 Novel anti-angiogenic agents; mutiple shots on goal. Stirling D SMI CONF ANTI-ARTHRITIC AGENTS April 2004
    • (2004) SMI Conf. Anti-Arthritic Agents
    • Stirling, D.1
  • 21
    • 18144425992 scopus 로고    scopus 로고
    • Celgene Corporation reports record operating performance in second quarter with strong revenue and profit growth
    • 550323 Celgene Corp PRESS RELEASE July 22
    • 550323 Celgene Corporation reports record operating performance in second quarter with strong revenue and profit growth. Celgene Corp PRESS RELEASE 2004 July 22
    • (2004)
  • 22
    • 0141630489 scopus 로고    scopus 로고
    • In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole- 3-yl]-glyoxylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration
    • 550581
    • 550581 In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole -3-yl]-glyoxylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration. Kuss H, Hoefgen N, Johanssen S, Kronbach T, Rundfeldt C J PHARMACOL EXP THER 2003 307 1 373-385
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , Issue.1 , pp. 373-385
    • Kuss, H.1    Hoefgen, N.2    Johanssen, S.3    Kronbach, T.4    Rundfeldt, C.5
  • 23
    • 1242268903 scopus 로고    scopus 로고
    • Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1- (4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations
    • 550583
    • 550583 Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1- (4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations. Draheim R, Egerland U, Rundfeldt C J PHARMACOL EXP THER 2004 308 2 555-563
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , Issue.2 , pp. 555-563
    • Draheim, R.1    Egerland, U.2    Rundfeldt, C.3
  • 24
    • 0842287256 scopus 로고    scopus 로고
    • The effects of selective cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and apoptosis in myeloma and endothelial cell co-cultures
    • 580212
    • 580212 The effects of selective cytokine inhibitory drugs (CC-10004 and CC-1088) on VEGF and IL-6 expression and apoptosis in myeloma and endothelial cell co-cultures. Molostvov G, Morris A, Rose P, Basu S, Muller G BR J HAEMATOL 2004 124 3 366-375
    • (2004) Br. J. Haematol. , vol.124 , Issue.3 , pp. 366-375
    • Molostvov, G.1    Morris, A.2    Rose, P.3    Basu, S.4    Muller, G.5
  • 26
    • 11844267183 scopus 로고    scopus 로고
    • Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
    • 583773
    • 583773 Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease. Lipworth BJ LANCET 2005 365 9454 167-175
    • (2005) Lancet , vol.365 , Issue.9454 , pp. 167-175
    • Lipworth, B.J.1
  • 27
    • 18144397374 scopus 로고    scopus 로고
    • Anti-Arthritis Therapies 2005
    • 587262 London, UK. IDDB MEETING REPORT February 23-24
    • 587262 Anti-Arthritis Therapies 2005, London, UK. Braddock M IDDB MEETING REPORT 2005 February 23-24
    • (2005)
    • Braddock, M.1
  • 28
    • 18144430874 scopus 로고    scopus 로고
    • Celgene Corp company profile from company website
    • 587324 Celgene Corp COMPANY WORLD WIDE WEB SITE October 22
    • 587324 Celgene Corp company profile from company website. Celgene Corp COMPANY WORLD WIDE WEB SITE 2004 October 22
    • (2004)
  • 30
    • 2942641713 scopus 로고    scopus 로고
    • 588333 Roflumilast: APTA 2217, B9302-107, BY 217, BYK 20869. No authors listed
    • 588333 Roflumilast: APTA 2217, B9302-107, BY 217, BYK 20869. No authors listed DRUGS R D 2004 5 3 176-181
    • (2004) Drugs R. D. , vol.5 , Issue.3 , pp. 176-181
  • 31
    • 0033043885 scopus 로고    scopus 로고
    • Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes
    • 588335
    • 588335 Phosphodiesterase 4-dependent regulation of cyclic AMP levels and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes. Denis D, Riendeau D EUR J PHARMACOL 1999 367 2-3 343-350
    • (1999) Eur. J. Pharmacol. , vol.367 , Issue.2-3 , pp. 343-350
    • Denis, D.1    Riendeau, D.2
  • 32
    • 0037163858 scopus 로고    scopus 로고
    • Crystal structure of phosphodiesterase 4D and inhibitor complex 1
    • 590470
    • 590470 Crystal structure of phosphodiesterase 4D and inhibitor complex 1. Lee ME, Markowitz J, Lee JO, Lee H FEBS LETT 2002 530 1-3 53-58
    • (2002) Febs. Lett. , vol.530 , Issue.1-3 , pp. 53-58
    • Lee, M.E.1    Markowitz, J.2    Lee, J.O.3    Lee, H.4
  • 33
    • 0038154006 scopus 로고    scopus 로고
    • Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
    • 591068
    • 591068 Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity. Huai Q, Wang H, Sun Y, Kim HY, Liu Y, Ke H STRUCTURE 2003 11 7 865-873
    • (2003) Structure , vol.11 , Issue.7 , pp. 865-873
    • Huai, Q.1    Wang, H.2    Sun, Y.3    Kim, H.Y.4    Liu, Y.5    Ke, H.6
  • 34
    • 0014985865 scopus 로고
    • Analogues of 4-(3,4-dimethoxybenzyl)-2-imidazolidinone as potent inhibitors of rat erythrocyte adenosine cyclic 3′,5′-phosphate phosphodiesterase
    • 591100
    • 591100 Analogues of 4-(3,4-dimethoxybenzyl)-2-imidazolidinone as potent inhibitors of rat erythrocyte adenosine cyclic 3′,5′-phosphate phosphodiesterase. Sheppard H, Wiggan G MOL PHARMACOL 1971 7 1 111-115
    • (1971) Mol. Pharmacol. , vol.7 , Issue.1 , pp. 111-115
    • Sheppard, H.1    Wiggan, G.2
  • 35
    • 4444330207 scopus 로고    scopus 로고
    • The potential of PDE4 inhibitors in respiratory disease
    • 592024
    • 592024 The potential of PDE4 inhibitors in respiratory disease. Spina D CURR DRUG TARGETS INFLAMM ALLERGY 2004 3 3 231-236
    • (2004) Curr. Drug Targets Inflamm. Allergy , vol.3 , Issue.3 , pp. 231-236
    • Spina, D.1
  • 36
    • 0742288911 scopus 로고    scopus 로고
    • Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors
    • 592298
    • 592298 Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors. Oger S, Mehats C, Barnette MS, Ferre F, Cabrol D, Leroy MJ BIOL REPROD 2004 70 2 458-464
    • (2004) Biol. Reprod. , vol.70 , Issue.2 , pp. 458-464
    • Oger, S.1    Mehats, C.2    Barnette, M.S.3    Ferre, F.4    Cabrol, D.5    Leroy, M.J.6
  • 37
    • 0141672004 scopus 로고    scopus 로고
    • The rebirth of a drug: Thaildomide
    • 592299
    • 592299 The rebirth of a drug: Thaildomide. Lima LM, Fraga CAM, Barreiro EJ QUÍM NOVA 2001 24 5 683-688.
    • (2001) Quím Nova , vol.24 , Issue.5 , pp. 683-688
    • Lima, L.M.1    Fraga, C.A.M.2    Barreiro, E.J.3
  • 38
    • 14944381008 scopus 로고    scopus 로고
    • Searching for a reliable orientation of ligands in their binding site: Comparison between a structure-based (Glide) and a ligand-based (FIGO) approach in the case study of PDE4 inhibitors
    • 592494
    • 592494 Searching for a reliable orientation of ligands in their binding site: Comparison between a structure-based (Glide) and a ligand-based (FIGO) approach in the case study of PDE4 inhibitors. Gratteri P, Bonaccini C, Melani F J MED CHEM 2005 48 5 1657-1665
    • (2005) J. Med. Chem. , vol.48 , Issue.5 , pp. 1657-1665
    • Gratteri, P.1    Bonaccini, C.2    Melani, F.3
  • 39
    • 18144415757 scopus 로고    scopus 로고
    • Case study: CC-10004, novel anti-arthritic agents
    • 592659 February 24-25
    • 592659 Case study: CC-10004, novel anti-arthritic agents. Bennet B B2B CONF - ANTI-ARTHRITIS THERAPIES 2005 February 24-25
    • (2005) B2B Conf. - Anti-Arthritis Therapies
    • Bennet, B.1


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