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Volumn 6, Issue 2, 2005, Pages 151-161

Genomics and new targets for multiple sclerosis

Author keywords

Genetics; Multiple sclerosis; Single nucleotide polymorphism

Indexed keywords

BETA INTERFERON; CYCLOPHOSPHAMIDE; DNA VACCINE; GLATIRAMER; GLUCOCORTICOID; INTERLEUKIN 14; MYELIN; NATALIZUMAB; RECOMBINANT BETA INTERFERON;

EID: 18144368861     PISSN: 14622416     EISSN: None     Source Type: Journal    
DOI: 10.1517/14622416.6.2.151     Document Type: Review
Times cited : (7)

References (49)
  • 1
    • 18144383963 scopus 로고    scopus 로고
    • Multiple sclererosis and other demyelinating diseases
    • (15th edn). Braunwald E, Fauci AD, Kasper DL, Hauser SL, Longo DL, Jameson JL (Eds), McGraw Hill, NY
    • Hauser SL, Goodin DE: Multiple sclererosis and other demyelinating diseases. In: Harrison's Principle of International Medicine (15th edn). Braunwald E, Fauci AD, Kasper DL, Hauser SL, Longo DL, Jameson JL (Eds), McGraw Hill, NY (2004).
    • (2004) Harrison's Principle of International Medicine
    • Hauser, S.L.1    Goodin, D.E.2
  • 3
    • 5144235394 scopus 로고    scopus 로고
    • Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines
    • Hohlfeld R, Wekerle H: Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc. Natl Acad. Sci. USA 101 (Suppl. 2), 14599-14606 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.SUPPL. 2 , pp. 14599-14606
    • Hohlfeld, R.1    Wekerle, H.2
  • 4
    • 0037029424 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A: Multiple sclerosis. Lancet 359, 1221-1231 (2002).
    • (2002) Lancet , vol.359 , pp. 1221-1231
    • Compston, A.1    Coles, A.2
  • 5
    • 0027164123 scopus 로고
    • Familial recurrence risks and inheritance of multiple sclerosis
    • Sadovnick AD: Familial recurrence risks and inheritance of multiple sclerosis. Curr. Opin. Neurol. Neurosurg. 6, 189-194 (1993).
    • (1993) Curr. Opin. Neurol. Neurosurg. , vol.6 , pp. 189-194
    • Sadovnick, A.D.1
  • 6
  • 7
    • 0029121088 scopus 로고
    • A genetic basis for familial aggregation in multiple sclerosis
    • Ebers GC, Sadovnick AD, Risch NJ: A genetic basis for familial aggregation in multiple sclerosis. Nature 377, 150-151 (1995).
    • (1995) Nature , vol.377 , pp. 150-151
    • Ebers, G.C.1    Sadovnick, A.D.2    Risch, N.J.3
  • 8
    • 0028128084 scopus 로고
    • The British Isles survey of multiple sclerosis in twins
    • Mumford CJ, Wood NW, Kellar-Wood H et al.: The British Isles survey of multiple sclerosis in twins. Neurology 44, 11-15 (1994).
    • (1994) Neurology , vol.44 , pp. 11-15
    • Mumford, C.J.1    Wood, N.W.2    Kellar-Wood, H.3
  • 9
    • 0033549026 scopus 로고    scopus 로고
    • Familial factors influence disability in MS multiplex families
    • French Multiple Sclerosis. Genetics Group
    • Brassat D, Azais-Vuillemin C, Yaouanq J et al.: Familial factors influence disability in MS multiplex families. French Multiple Sclerosis. Genetics Group. Neurology 52, 1632-1636 (1999).
    • (1999) Neurology , vol.52 , pp. 1632-1636
    • Brassat, D.1    Azais-Vuillemin, C.2    Yaouanq, J.3
  • 10
    • 0036151386 scopus 로고    scopus 로고
    • Genetic basis for clinical expression in multiple sclerosis
    • Barcellos LF, Oksenberg JR, Green AJ et al.: Genetic basis for clinical expression in multiple sclerosis. Brain 125, 150-158 (2002).
    • (2002) Brain , vol.125 , pp. 150-158
    • Barcellos, L.F.1    Oksenberg, J.R.2    Green, A.J.3
  • 12
    • 15844366743 scopus 로고    scopus 로고
    • A full genome search in multiple sclerosis
    • Ebers GC, Kukay K, Bulman DE et al.: A full genome search in multiple sclerosis. Nat. Genet. 13, 472-476 (1996).
    • (1996) Nat. Genet. , vol.13 , pp. 472-476
    • Ebers, G.C.1    Kukay, K.2    Bulman, D.E.3
  • 13
    • 0009573338 scopus 로고    scopus 로고
    • A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex
    • Haines JL, Ter-Minassian M, Bazyk A et al.: A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat. Genet. 13, 469-471 (1996).
    • (1996) Nat. Genet. , vol.13 , pp. 469-471
    • Haines, J.L.1    Ter-Minassian, M.2    Bazyk, A.3
  • 14
    • 15844368830 scopus 로고    scopus 로고
    • A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22
    • Sawcer S, Jones HB, Feakes R et al.: A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat. Genet. 13, 464-468 (1996).
    • (1996) Nat. Genet. , vol.13 , pp. 464-468
    • Sawcer, S.1    Jones, H.B.2    Feakes, R.3
  • 15
    • 17744398193 scopus 로고    scopus 로고
    • A meta-analysis of genomic screens in multiple sclerosis
    • The Transatlantic Multiple Sclerosis Cooperative
    • The Transatlantic Multiple Sclerosis Cooperative: A meta-analysis of genomic screens in multiple sclerosis. Mult. Scler. 7, 3-11 (2001).
    • (2001) Mult. Scler. , vol.7 , pp. 3-11
  • 16
    • 0142186253 scopus 로고    scopus 로고
    • A meta-analysis of whole genome linkage screens in multiple sclerosis
    • GAMES, Transatlantic Multiple Sclerosis Genetics Cooperative
    • GAMES, Transatlantic Multiple Sclerosis Genetics Cooperative: A meta-analysis of whole genome linkage screens in multiple sclerosis. J. Neuroimmunol. 143, 39-46 (2003).
    • (2003) J. Neuroimmunol. , vol.143 , pp. 39-46
  • 17
    • 0037371325 scopus 로고    scopus 로고
    • HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course
    • Barcellos LF, Oksenberg JR, Begovich AB et al.: HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am. J. Hum. Genet. 72, 710-716 (2003).
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 710-716
    • Barcellos, L.F.1    Oksenberg, J.R.2    Begovich, A.B.3
  • 18
    • 0035846467 scopus 로고    scopus 로고
    • HLA-DRB1*1501 and response to copolymer-1 therapy in relapsing-remitting multiple sclerosis
    • Fusco C, Andreone V, Coppola G et al.: HLA-DRB1*1501 and response to copolymer-1 therapy in relapsing-remitting multiple sclerosis. Neurology 57, 1976-1979 (2001).
    • (2001) Neurology , vol.57 , pp. 1976-1979
    • Fusco, C.1    Andreone, V.2    Coppola, G.3
  • 19
    • 7344223861 scopus 로고    scopus 로고
    • Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity
    • Haines JL, Terwedow HA, Burgess K et al.: Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. Hum. Mol. Genet. 7, 1229-1234 (1998).
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1229-1234
    • Haines, J.L.1    Terwedow, H.A.2    Burgess, K.3
  • 21
    • 18444369013 scopus 로고    scopus 로고
    • The structure of haplotype blocks in the human genome
    • Gabriel SB, Schaffner SF, Nguyen H et al.: The structure of haplotype blocks in the human genome. Science 296, 2225-2229 (2002).
    • (2002) Science , vol.296 , pp. 2225-2229
    • Gabriel, S.B.1    Schaffner, S.F.2    Nguyen, H.3
  • 22
    • 0033772073 scopus 로고    scopus 로고
    • Genetic variation in the gene encoding calpain-10 is associated with Type 2 diabetes mellitus
    • Horikawa Y, Oda N, Cox NJ et al.: Genetic variation in the gene encoding calpain-10 is associated with Type 2 diabetes mellitus. Nat. Genet. 26, 163-175 (2000).
    • (2000) Nat. Genet. , vol.26 , pp. 163-175
    • Horikawa, Y.1    Oda, N.2    Cox, N.J.3
  • 23
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N et al.: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606 (2001).
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 24
    • 0034785352 scopus 로고    scopus 로고
    • Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
    • Rioux JD, Daly MJ, Silverberg MS et al.: Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat. Genet. 29, 223-228 (2001).
    • (2001) Nat. Genet. , vol.29 , pp. 223-228
    • Rioux, J.D.1    Daly, M.J.2    Silverberg, M.S.3
  • 25
    • 0037173639 scopus 로고    scopus 로고
    • Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    • Van Eerdewegh P, Little RD, Dupuis J et al.: Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418, 426-430 (2002).
    • (2002) Nature , vol.418 , pp. 426-430
    • Van Eerdewegh, P.1    Little, R.D.2    Dupuis, J.3
  • 26
    • 11144357144 scopus 로고    scopus 로고
    • Characterization of a common susceptibility locus for asthma-related traits
    • Laitinen T, Polvi A, Rydman P et al.: Characterization of a common susceptibility locus for asthma-related traits. Science 304, 300-304 (2004).
    • (2004) Science , vol.304 , pp. 300-304
    • Laitinen, T.1    Polvi, A.2    Rydman, P.3
  • 28
    • 0037265618 scopus 로고    scopus 로고
    • The CTLA4 region as a general autoimmunity factor: An extended pedigree provides evidence for synergy with the HLA locus in the etiology of Type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' disease
    • Einarsdottir E, Soderstrom I, Lofgren-Burstrom A et al.: The CTLA4 region as a general autoimmunity factor: an extended pedigree provides evidence for synergy with the HLA locus in the etiology of Type 1 diabetes mellitus, Hashimoto's thyroiditis and Graves' disease. Eur. J. Hum. Genet. 11, 81-84 (2003).
    • (2003) Eur. J. Hum. Genet. , vol.11 , pp. 81-84
    • Einarsdottir, E.1    Soderstrom, I.2    Lofgren-Burstrom, A.3
  • 30
    • 0032882174 scopus 로고    scopus 로고
    • Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays
    • Whitney LW, Becker KG, Tresser NJ et al.: Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. Ann. Neurol. 46, 425-428 (1999).
    • (1999) Ann. Neurol. , vol.46 , pp. 425-428
    • Whitney, L.W.1    Becker, K.G.2    Tresser, N.J.3
  • 31
    • 0035941106 scopus 로고    scopus 로고
    • The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease
    • Chabas D, Baranzini SE, Mitchell D et al.: The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 294, 1731-1735 (2001).
    • (2001) Science , vol.294 , pp. 1731-1735
    • Chabas, D.1    Baranzini, S.E.2    Mitchell, D.3
  • 32
    • 0029060142 scopus 로고
    • The small heat-shock protein α B-crystallin as candidate autoantigen in multiple sclerosis
    • van Noort JM, van Sechel AC, Bajramovic JJ et al.: The small heat-shock protein α B-crystallin as candidate autoantigen in multiple sclerosis. Nature 375, 798-801 (1995).
    • (1995) Nature , vol.375 , pp. 798-801
    • van Noort, J.M.1    van Sechel, A.C.2    Bajramovic, J.J.3
  • 33
    • 0036105484 scopus 로고    scopus 로고
    • Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
    • Lock C, Hermans G, Pedotti R et al.: Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 8, 500-508 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 500-508
    • Lock, C.1    Hermans, G.2    Pedotti, R.3
  • 34
    • 0242667881 scopus 로고    scopus 로고
    • Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult
    • Graumann U, Reynolds R, Steck AJ, Schaeren-Werners N: Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult. Brain Pathol. 13, 554-573 (2003).
    • (2003) Brain Pathol. , vol.13 , pp. 554-573
    • Graumann, U.1    Reynolds, R.2    Steck, A.J.3    Schaeren-Werners, N.4
  • 35
    • 3042653294 scopus 로고    scopus 로고
    • Multiple sclerosis as a generalized CNS disease. Comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS
    • Lindberg RL, De Groot CJ, Certa U et al.: Multiple sclerosis as a generalized CNS disease. Comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS. J. Neuroimmunol. 152, 154-167 (2004).
    • (2004) J. Neuroimmunol. , vol.152 , pp. 154-167
    • Lindberg, R.L.1    De Groot, C.J.2    Certa, U.3
  • 36
    • 0036400367 scopus 로고    scopus 로고
    • Large-scale gene-expression studies and the challenge of multiple sclerosis
    • Baranzini SE, Hauser SL: Large-scale gene-expression studies and the challenge of multiple sclerosis. Genome Biol. 3, 1027 (2002).
    • (2002) Genome Biol. , vol.3 , pp. 1027
    • Baranzini, S.E.1    Hauser, S.L.2
  • 37
    • 10744231299 scopus 로고    scopus 로고
    • Gene expression profile in multiple sclerosis patients and healthy controls: Identifying pathways relevant to disease
    • Bomprezzi R, Ringner M, Kim S et al.: Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Hum. Mol. Genet. 12, 2191-2199 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2191-2199
    • Bomprezzi, R.1    Ringner, M.2    Kim, S.3
  • 38
    • 1442304886 scopus 로고    scopus 로고
    • Blood transcriptional signatures of multiple sclerosis: Unique gene expression of disease activity
    • Achiron A, Gurevich M, Friedman N, Kaminski N, Mandel M: Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity. Ann. Neurol. 55, 410-417 (2004).
    • (2004) Ann. Neurol. , vol.55 , pp. 410-417
    • Achiron, A.1    Gurevich, M.2    Friedman, N.3    Kaminski, N.4    Mandel, M.5
  • 39
    • 7444234286 scopus 로고    scopus 로고
    • Getting the noise out of gene arrays
    • Marshall E: Getting the noise out of gene arrays. Science 306, 630-631 (2004).
    • (2004) Science , vol.306 , pp. 630-631
    • Marshall, E.1
  • 40
    • 0019856763 scopus 로고
    • Intrathecal interferon reduces exacerbations of multiple sclerosis
    • Jacobs L, O'Malley J, Freeman A, Ekes R: Intrathecal interferon reduces exacerbations of multiple sclerosis. Science 214, 1026-1028 (1981).
    • (1981) Science , vol.214 , pp. 1026-1028
    • Jacobs, L.1    O'Malley, J.2    Freeman, A.3    Ekes, R.4
  • 41
    • 0023038777 scopus 로고
    • Multicentre double-blind study of effect of intrathecally administered natural human fibroblast interferon on exacerbations of multiple sclerosis
    • Jacobs L, Salazar AM, Herndon R et al.: Multicentre double-blind study of effect of intrathecally administered natural human fibroblast interferon on exacerbations of multiple sclerosis. Lancet 2, 1411-1413 (1986).
    • (1986) Lancet , vol.2 , pp. 1411-1413
    • Jacobs, L.1    Salazar, A.M.2    Herndon, R.3
  • 43
    • 0036789860 scopus 로고    scopus 로고
    • Assessment of different treatment failure criteria in a cohort of relapsing-remitting multiple sclerosis patients treated with interferon beta: Implications for clinical trials
    • Rio J, Nos C, Tintore M et al.: Assessment of different treatment failure criteria in a cohort of relapsing-remitting multiple sclerosis patients treated with interferon beta: implications for clinical trials. Ann. Neurol. 52, 400-406 (2002).
    • (2002) Ann. Neurol. , vol.52 , pp. 400-406
    • Rio, J.1    Nos, C.2    Tintore, M.3
  • 44
    • 0036022681 scopus 로고    scopus 로고
    • Therapeutic approaches in multiple sclerosis: Lessons from failed and interrupted treatment trials
    • Wiendl H, Hohlfeld R: Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials. BioDrugs 16, 183-200 (2002).
    • (2002) BioDrugs , vol.16 , pp. 183-200
    • Wiendl, H.1    Hohlfeld, R.2
  • 45
    • 0036709630 scopus 로고    scopus 로고
    • The HLA locus and multiple sclerosis in Spain. Role in disease susceptibility, clinical course and response to interferon-β
    • Villoslada P, Barcellos L, Rio J et al.: The HLA locus and multiple sclerosis in Spain. Role in disease susceptibility, clinical course and response to interferon-β. J. Neuroimmunol. 130, 194-201 (2002).
    • (2002) J. Neuroimmunol. , vol.130 , pp. 194-201
    • Villoslada, P.1    Barcellos, L.2    Rio, J.3
  • 46
    • 0642278522 scopus 로고    scopus 로고
    • Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis
    • Sriram U, Barcellos LF, Villoslada P et al.: Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. Genes Immun. 4, 147-152 (2003).
    • (2003) Genes Immun. , vol.4 , pp. 147-152
    • Sriram, U.1    Barcellos, L.F.2    Villoslada, P.3
  • 47
    • 3042513728 scopus 로고    scopus 로고
    • Gene expression profiling of relevant biomarkers for treatment evaluation in multiple sclerosis
    • Hong J, Zang YC, Hutton G, Rivera VM, Zhang JZ: Gene expression profiling of relevant biomarkers for treatment evaluation in multiple sclerosis. J. Neuroimmunol. 152, 126-139 (2004).
    • (2004) J. Neuroimmunol. , vol.152 , pp. 126-139
    • Hong, J.1    Zang, Y.C.2    Hutton, G.3    Rivera, V.M.4    Zhang, J.Z.5
  • 48
    • 0042930859 scopus 로고    scopus 로고
    • Genomic effect of IFN-β in multiple sclerosis patients
    • Weinstock-Guttman B, Badgett D, Patrick K et al.: Genomic effect of IFN-β in multiple sclerosis patients. J. Immunol. 171, 2694-2702 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 2694-2702
    • Weinstock-Guttman, B.1    Badgett, D.2    Patrick, K.3
  • 49
    • 20044373640 scopus 로고    scopus 로고
    • Transcription-based prediction of response to IFNβ using supervised computational methods
    • 3e2
    • Baranzini SE, Mousav P, Rio J et al.: Transcription-based prediction of response to IFNβ using supervised computational methods. PLOS Biol. 3e2, 1-11 (2005).
    • (2005) PLOS Biol. , pp. 1-11
    • Baranzini, S.E.1    Mousav, P.2    Rio, J.3


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