Genetic susceptibility to MS: A second stage analysis in Canadian MS families

Neurogenetics

Volumn 3, Issue 3, 2001, Pages 145-151

  Dyment, David A ^b   Willer, Cristen J ^b   Scott, Beverly ^c   Armstrong, Holly ^c   Ligers, Arturs ^d   Hillert, Jan ^d   Paty, Donald W ^e   Hashimoto, Stanley ^e   Devonshire, Virginia ^e   Hooge, John ^e   Kastrukoff, Lorne ^e   Oger, Joel ^e   Metz, Luanne ^f   Warren, Sharon ^g   Hader, Walter ^h   Power, Cristopher ⁱ   Auty, Anthony ⁱ   Nath, Avindra ⁱ   Nelson, Robert ^j   Freedman, Mark ^j   Brunet, Donald ^k   Paulseth, John E ^l   Rice, George ^c   O'Connor, Paul ^c,m   Duquette, Pierre ⁿ   Lapierre, Yves ^o   Francis, Gordon ^o   Bouchard, Jean Pierre ^p   Murray, T John ^q   Bhan, Virender ^q   Maxner, Charles ^q   Pryse Phillips, William ^r   Stefanelli, Mark ^r   Sadovnick, A Dessa ^e   Risch, Neil ^s   Ebers, George C ^a,b   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f UNIVERSITY OF CALGARY   (Canada)

^g UNIVERSITY OF ALBERTA   (Canada)

^h Department of Rehabilatory Medicine ^*  (Canada)

ⁱ UNIVERSITY OF MANITOBA   (Canada)

^j UNIVERSITY OF OTTAWA   (Canada)

^k QUEEN S UNIVERSITY   (Canada)

^l MCMASTER UNIVERSITY   (Canada)

^m UNIVERSITY OF TORONTO   (Canada)

ⁿ UNIVERSITÉ DE MONTRÉAL   (Canada)

^o MCGILL UNIVERSITY   (Canada)

^p UNIVERSITÉ LAVAL   (Canada)

^q DALHOUSIE UNIVERSITY   (Canada)

^r MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^s STANFORD UNIVERSITY   (United States)

more..

Author keywords

Linkage analysis; Multiple sclerosis; Susceptibility loci

Indexed keywords

HLA DR ANTIGEN; HLA-DRB1 ANTIGEN;

ARTICLE; CANADA; CLINICAL TRIAL; COMPUTER PROGRAM; FAMILY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC LINKAGE; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; GENOME; HUMAN; MALE; MULTICENTER STUDY; MULTIPLE SCLEROSIS; NUCLEAR FAMILY;

CANADA; FAMILY; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HLA-DR ANTIGENS; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; MALE; MULTIPLE SCLEROSIS; NUCLEAR FAMILY; SOFTWARE;

EID: 18044399829     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100480100113     Document Type: Article

References (35)

1. Ebers GC, Sadovnick AD, Risch NJ and the Canadian Collaborative Study Group (1995) A genetic basis for familial aggregation in multiple sclerosis. Nature 377:150-151
2. Sadovnick AD, Ebers GC, Dyment DA, Risch NJ and the Canadian Collaborative Study Group (1996) Evidence for the genetic basis of multiple sclerosis. Lancet 347:1728-1730
3. Sadovnick AD, Dyment D, Ebers GC (1997) Genetic epidemiology of multiple sclerosis. Epidemiol Rev 19:99-106
4. Robertson NP, O'Riordan JL, Chataway J, Kingsley DP, Miller DH, Clayton D, Compston DA (1997) Offspring recurrence rates and clinical characteristics of conjugal multiple sclerosis. Lancet 349:1587-1590
5. Sadovnick AD, Baird PA, Ward RH (1988) Multiple sclerosis: updated risks for relatives. Am J Med Gen 29:533-541
6. Sadovnick AD, Armstrong H, Rice GP, Bulman D, Hashimoto L, Paty DW, Hashimoto SA, Warren S, Hader W, Murray TJ, Seland TP, Metz L, Bell R, Duquette P, Gray T, Nelson R, Weinshenker B, Brunet D, Ebers GC (1993) A population-based study of multiple sclerosis in twins: update. Ann Neurol 33:281-285
7. Mumford CJ, Wood NW, Kellar-Wood H, Thorpe JW, Miller DH, Compston DA (1994) The British Isles survey of multiple sclerosis in twins. Neurology 44:11-15
8. Rivers TM, Schwentker FF (1935) Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys. J Exp Med 58:39-53
9. Kabat EA, Bezer AE (1946) The rapid production of acute disseminated encephalomyelitis in Rhesus monkeys by injection of brain tissue with adjuvants. Science 104:362-363
10. Dyment DA, Sadovnick AD, Ebers GC (1997) Genetics of multiple sclerosis. Hum Mol Genet 6:1693-1698
11. Sawcer S, Goodfellow PN, Compston A (1997) The genetic analysis of multiple sclerosis. Trends Genet 13:234-239
12. Olerup O, Hillert J (1991) HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens 38:1-15
13. Fogdell A, Hilleret J, Sachs C, Olerup O (1995) The multiple sclerosis- and narcolepsy-associated HLA class II haplotype includes DRB5*0101 allele. Tissue Antigens 46:333-336
14. Marrosu MG, Fadda E, Mancosu C, Lai M, Cocco E, Pugliati M (2000) The contribution of HLA to multiple sclerosis susceptibility in Sardinian affected sibling pairs. Ann Neurol 47:411-412
15. Sawcer S, Jones HB, Feakes R, Gray J, Smaldon N, Chataway J, Robertson N, Clayton D, Goodfellow PN, Compston A (1996) A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet 13: 464-468
16. The Multiple Sclerosis Genetics Group (1996) A complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. Nat Genet 13:469-471
17. Ebers GC, Kukay K, Bulman DE, Sadovnick AD, Rice G, Anderson C, Armstrong H, Cousin K, Bell, RB, Hader W, Paty DW, Hashimoto S, Oger J, Duquette P, Warren S, Gray T, O'Connor P, Nath A, Auty A, Metz L, Francis G, Paulseth JE, Murray TJ, Pryse-Phillips W, Nelson R, Freedman M, Brunet D, Bouchard J-P, Hinds D, Risch N (1996) A full genome search in multiple sclerosis. Nat Genet 13:472-476
18. Kuokkanen S, Gschwend M, Rioux JD, Daly MJ, Terwilliger JD, Tienari PJ, Wikstrom J, Palo J, Stein LD, Hudson TJ, Lander ES, Peltonen L (1997) Genomewide scan of multiple sclerosis in Finnish multiplex families. Am J Hum Genet 61: 1379-1387
19. Sadovnick AD, Risch NJ, Ebers GC and the Canadian Collaborative Study Group (1998) The Canadian collaborative project on the genetic susceptibility to MS, phase 2: rationale and method. Can J Neurol Sci 25:216-221
20. Olerup O, Zetterquist H (1992) HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 39:225-235
21. Spielman RS, McGinnis RE, Ewens WJ (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516
22. Suarez BK, Hampe CL, Eerdewegh PV (1994) Problems of replicating linkage claims in psychiatry. In Gershon ES, Cloninger CR, Barrett JE (eds) Genetic approaches to mental disorders. American Psychiatric Press, Washington, D.C., pp 23-46
23. Fogdell-Hahn A, Ligers A, Gronning M, Hillert J, Olerup O (2000) Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease. Tissue Antigens 55:140-148
24. Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science 273:1516-1517
25. Oturai A, Larsen F, Ryder LP, Madsen HO, Hillert J, Fredrikson S, Sandberg-Wollheim M, Laaksonen M, Koch-Henriksen N, Sawcer S, Fugger L, Sorensen PS, Svejgaard A (1999) Linkage and association analysis of susceptibility regions on chromosome 5 and 6 in 106 Scandinavian sibling pair families with multiple sclerosis. Ann Neurol 46:612-616
26. Larsen F, Oturai A, Ryder LP, Madsen HO, Hillert J, Fredrikson S, Sandberg-Wollheim M, Laaksonen M, Harbo HF, Saweer S, Fugger L, Sorensen PS, Svejgaard A (2000) Linkage analysis of a candidate region in Scandinavian sib pairs with multiple sclerosis reveals linkage to chromosome 17q. Genes Immun 7:456-459
27. Nelissen I, Fiten P, Vandenbroeck K, Hillert J, Ollson T, Marrosu MG, Opdenakker G (2000) PECAM1, MPO and PRKAR1 A at chromosome 17q21-q24 and susceptibility for multiple sclerosis in Sweden and Sardinia. J Neuroimmunol 108:153-159
28. Chataway J, Sawcer S, Feakes R, Coraddu F, Broadley S, Jones HB, Clayton D, Gray J, Goodfellow PN, Compston A (1999) A screen of candidates from peaks of linkage: evidence for the involvement of myeloperoxidase in multiple sclerosis. J Neuroimmunol 98:208-213
29. Brennan M-L, Gaur A, Pahuja A, Lusis AJ, Reynolds WF (2001) Mice lacking myeloperoxidase are more susceptible to experimental autoimmune encephalomyelitis. J Neuroimmunol 112:97-105
30. Nagra RM, Becher B, Toutrllotte WW, Antel JP, Gold D, Paladino T, Smith RA, Nelson JR, Reynolds WF (1997) Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis. J Neuroimmunol 78:97-107
31. Kantarci OH, Atkinson MS, Hebrink DD, McMurray CT, Weinshenker BG (2000) Association of a myeloperoxidase promoter polymorphism with multiple sclerosis. J Neuroimmunol 105:189-194
32. Transatlantic Multiple Sclerosis Genetics Cooperative (2001) A meta-analysis of genomic screens in multiple sclerosis. Mult Scler (in press)
33. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
34. Poser CM, Paty DW, Scheinberg L, McDonald W, Davis F, Ebers GC, Johnson K, Sibley W, Silberberg D, Tourtelotte W (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227-231
35. Schumacher GA, Beebe G, Kibler RF, Kurland LT, Kurtzke JF, McDowell F, Nagler B, Sibley WA, Tourtellotte WW, Wellmon TL (1965) Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann N Y Acad of Sci 122:552-568