Genetic epidemiology of multiple sclerosis

Epidemiologic Reviews

Volumn 19, Issue 1, 1997, Pages 99-106

  Sadovnick, A Dessa ^a,b   Dyment, D ^a,b,c   Ebers, G C ^c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VANCOUVER HOSPITAL AND HEALTH SCIENCES CENTRE   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; LYMPHOTOXIN; MYELIN BASIC PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

DISEASE ASSOCIATION; DISEASE TRANSMISSION; EPIDEMIC; FAMILY STUDY; GENETIC EPIDEMIOLOGY; GENETIC MODEL; GENETIC SCREENING; GEOGRAPHIC DISTRIBUTION; HUMAN; INHERITANCE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; REVIEW;

EID: 0030722553     PISSN: 0193936X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.epirev.a017951     Document Type: Review

References (101)

1. Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;13:227-31.
2. Duquette P, Murray TJ, Pleines J, et al. Multiple sclerosis in childhood: clinical profile in 125 patients. J Pediatr 1987; 111:359-63.
3. Noseworthy J, Paty DW, Wonnacott T, et al. Multiple sclerosis after age 50. Neurology 1983;33:1537-44.
4. Spielman RS, Nathanson N. The genetics of susceptibility to multiple sclerosis. Epidemiol Rev 1982;4:45-65.
5. Jersild C, Svejgaard A, Fog T. HL-A antigens and multiple sclerosis. Lancet 1972;1:1240-1.
6. Ebers GC, Bulman DE, Sadovnick AD, et al. A population-based study in multiple sclerosis in twins. N Engl J Med 1986;315:1638-42.
7. Sadovnick AD, Armstrong H, Rice GPA, et al. A population-based study of multiple sclerosis in twins: update. Ann Neurol 1993;33:281-5.
8. Mumford CJ, Wood NW, Kellar-Wood H, et al. The British Isles survey of multiple sclerosis in twins. Neurology 1994; 44:11-15.
9. Ebers GC, Sadovnick AD, Risch NJ. A genetic basis for familial aggregation in multiple sclerosis. Canadian Collaborative Study Group. Nature 1995;377:150-1.
10. Sadovnick AD, Ebers GC, Dyment DA, et al. Evidence for genetic basis of multiple sclerosis. The Canadian Collaborative Study Group. Lancet 1996;347:1728-30.
11. Sadovnick AD, Baird PA, Ward RH. Multiple sclerosis: updated risks for relatives. Am J Med Genet 1988;29: 533-41.
12. Carton H, Vlietinck R, Debruyne J, et al. Risks of multiple sclerosis in relatives of patients in Flanders, Belgium. J Neurol Neurosurg Psychiatry 1997;62:329-33.
13. Robertson NP, Fraser M, Deans J, et al. Age-adjusted recurrence risks for relatives of patients with multiple sclerosis. Brain 1996;119:449-55.
14. Ebers GC, Kukay K, Bulman DE, et al. A full genome search in multiple sclerosis. Nat Genet 1996;13:472-6.
15. Sawcer S, Jones HB, Feakes R, et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet 1996;13:464-8.
16. Haines JL, Ter-Minassian M, Bazyk A, et al. Complete genomic screen for multiple sclerosis underscores a role for the major histocompatibility complex. The Multiple Sclerosis Genetics Group. Nat Genet 1996;13:469-71.
17. Sadovnick AD, Ebers GC. Epidemiology of multiple sclerosis: a critical overview. Can J Neurol Sci 1993;20: 17-29.
18. Kurtzke JF. Epidemiologic evidence for multiple sclerosis as an infection. Clin Microbiol Rev 1993;6:382-427.
19. Kurtzke JF. Geography in multiple sclerosis. J Neurol 1977; 215:1-26.
20. Kurtzke JF, Beebe GW, Norman JE Jr. Epidemiology of multiple sclerosis in US veterans. 1. Race, sex, and geographic distribution. Neurology 1979;29:1228-35.
21. Bulman DE, Ebers GC. The geography of multiple sclerosis reflects genetic susceptibility. J Trop Geogr Neurol 1992;2: 66-72.
22. Ebers GC, Sadovnick AD. The geographic distribution of multiple sclerosis: a review. (Editorial). Neuroepidemiology 1993;12:1-5.
23. Hammond SR, McLeod JG, Millingen KS, et al. The epidemiology of multiple sclerosis in three Australian cities: Perth, Newcastle and Hobart. Brain 1988;111:1-25.
24. Dean G. Annual incidence, prevalence, and mortality of multiple sclerosis in white South-African-born and in white immigrants to South Africa. Br Med J 1967;2:724-30.
25. Alter M, Halpern L, Kurland LT, et al. Multiple sclerosis in Israel: prevalence among immigrants and native inhabitants. Arch Neurol 1962;7:253-63.
26. Sheremata WA, Poskanzer DC, Withum DG, et al. Unusual occurrence on a tropical island of multiple sclerosis. (Letter). Lancet 1985;2:618.
27. Irvine DG, Schiefer HB, Hader WJ. Geotoxicology of multiple sclerosis: the Henribourg, Saskatchewan, cluster focus. II. The soil. Sci Total Environ 1988;77:175-88.
28. Larsen JP, Riise T, Nyland H, et al. Clustering of multiple sclerosis in the county of Hordaland, Western Norway. Acta Neurol Scand 1985;71:390-95.
29. Kurtzke JF, Hyllested K. Multiple sclerosis in the Faroe Islands. I. Clinical and epidemiological features. Ann Neurol 1979;5:6-21.
30. Kurtzke JF, Hyllested K. Multiple sclerosis in the Faroe Islands. II. Clinical update, transmission, and the nature of MS. Neurology 1986;36:307-28.
31. Kurtzke JF, Gudmundsson KR, Bergmann S. Multiple sclerosis in Iceland. 1. Evidence of a postwar epidemic. Neurology 1982;32:143-50.
32. Poser CM, Hibberd PL, Benedikz, et al. Analysis of the "epidemic" of multiple sclerosis in the Faroe Islands. I. Clinical and epidemiological aspects. Neuroepidemiology 1988;7:168-80.
33. Poser CM, Hibberd PL. Analysis of the "epidemic" of multiple sclerosis in the Faroe Islands. II. Biostatistical aspects. Neuroepidemiology 1988;7:181-9.
34. Kurtzke JF, Hyllested K. Validity of the epidemics of multiple sclerosis in the Faroe Islands. Neuroepidemiology 1988; 7:190-227.
35. Acheson ED. Epidemiology of multiple sclerosis. Br Med Bull 1977;33:9-14.
36. Swank RL. Multiple sclerosis: a correlation of its incidence with dietary fat. Am J Med Sci 1950;220:421-30.
37. Butler EJ. Chronic neurological disease as a possible form of lead poisoning. J Neurol Neurosurg Psychiatry 1952;15: 119-28.
38. Bamford CR, Sibley WA, Thies C, et al. Trauma as an etiologic and aggravating factor in multiple sclerosis. Neurology 1981;31:1229-34.
39. Runmarker B, Andersen O. Pregnancy is associated with a lower risk of onset and a better prognosis in multiple sclerosis. Brain 1995;118:253-61.
40. Holmes FF, Stubbs DW, Larsen WE. Systemic lupus erythematosus and multiple sclerosis in identical twins. Arch Intern Med 1967; 119:302-4.
41. Shakir RA, Hussien JM, Trontelj JV. Myasthenia gravis and multiple sclerosis. J Neuroimmunol 1983;4:161-5.
42. Thomas DJ, Kendall MJ, Whitfield AGW. Nervous system involvement in ankylosing spondylitis. Br Med J 1974;1: 148-50.
43. Matthews WB. Some aspects of the natural history. In: Matthews WB, Acheson ED, Batchelor JR, et al., eds. McAlpine's multiple sclerosis. New York, NY: Churchill Livingstone, 1985:73-95.
44. Sadovnick AD, Paty DW, Yannakoulias G. Concurrence of multiple sclerosis and inflammatory bowel disease. (Letter). N Engl J Med 1989:321:762-3.
45. Bias WB, Reveille JD, Beaty TH, et al. Evidence that autoimmunity in man is a Mendelian dominant trait. Am J Hum Genet 1986;39:584-602.
46. Sadovnick AD, Bulman D, Ebers GC. Parent-child concordance in multiple sclerosis. Ann Neurol 1991;29:252-5.
47. Bulman DE, Sadovnick AD, Ebers GC. Age of onset in siblings concordant for multiple sclerosis. Brain 1991;114: 937-50.
48. Schapira K, Poskanzer DC, Miller H. Familial and conjugal multiple sclerosis. Brain 1963;86:315-32.
49. Sadovnick AD, Remick RA, Allen J, et al. Depression and multiple sclerosis. Neurology 1996;46:628-32.
50. Sadovnick AD, Eisen K, Ebers GC, et al. Cause of death in patients attending multiple sclerosis clinics. Neurology 1991; 41:1193-6.
51. Ebers GC, Sadovnick AD. The role of genetic factors in multiple sclerosis susceptibility. J Neuroimmunol 1994;54: 1-17.
52. Isager H, Andersen E, Hyllested K. Risk of multiple sclerosis inversely associated with birth order position. Acta Neurol Scand 1980;61:393-6.
53. Visscher BR, Liu KS, Sullivan CB, et al. Birth order and multiple sclerosis. Acta Neurol Scand 1982;66:209-15.
54. Gaudet JPC, Hashimoto L, Sadovnick AD, et al. A study of birth order and multiple sclerosis in multiplex families. Neuroepidemiology 1995;14:188-92.
55. Gaudet JPC, Hashimoto L, Sadovnick AD, et al. Is sporadic MS caused by an infection of adolescence and early childhood? A case-control study of birth order position. Acta Neurol Scand 1995;91:19-21.
56. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990;46:222-8.
57. Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 1990;46:229-41.
58. Olerup O, Hillert J. HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens 1991;38:1-15.
59. Tienari PJ, Wikstrom J, Koskimies S, et al. Reappraisal of HLA in multiple sclerosis: close linkage in multiplex families. Eur J Hum Genet 1993;1:257-68.
60. Ebers GC, Paty DW, Stiller CR, et al. HLA-typing in multiple sclerosis sibling pairs. Lancet 1982;2:88-90.
61. Kellar-Wood HF, Wood NW, Holmans P, et al. Multiple sclerosis and the HLA-D region: linkage and association studies. J Neuroimmunol 1995;58:183-90.
62. Kuokkanen S, Sundvall M, Terwilliger JD, et al. A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Nat Genet 1996;13:477-80.
63. Compston A, Howard S. HLA typing in multiple sclerosis. (Letter). Lancet 1982;2:661.
64. Stewart GJ, McLeod JG, Basten A, et al. HLA family studies and multiple sclerosis: a common gene, dominantly expressed. Human Immunol 1981;3:13-29.
65. Govaerts A, Gony J, Martin-Mondiere C, et al. HLA and multiple sclerosis: population and families study. Tissue Antigens 1985;25:187-99.
66. Risch N. Assessing the role of HLA-linked and unlinked determinants of disease. Am J Hum Genet 1987;40:1-14.
67. α alleles associated with multiple sclerosis and myasthenia gravis. Proc Natl Acad Sci U S A 1989;86: 988-92.
68. Hillert J, Leng C, Olerup O. T-cell receptor α chain germline gene polymorphisms in multiple sclerosis. Neurology 1992; 42:80-4.
69. Hashimoto LL, Mak TW, Ebers GC. T-cell receptor α chain polymorphisms in multiple sclerosis. J Neuroimmunol 1992; 40:41-8.
70. Lynch SG, Rose JW, Petajan JH, et al. Discordance of the T-cell receptor alpha-chain gene in familial multiple sclerosis. Neurology 1992;42:839-44.
71. Beall SS, Concannon P, Charmley P, et al. The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis. J Neuroimmunol 1989;21:59-66.
72. Charmley P, Beall SS, Concannon P, et al. Further localization of a multiple sclerosis susceptibility gene on chromosome 7q using a new T cell receptor beta-chain DNA polymorphism. J Neuroimmunol 1991;32:231-40.
73. Fugger L, Sandberg-Wollheim M, Morling N, et al. The germline repertoire of T-cell receptor β chain genes in patients with relapsing/remitting multiple sclerosis or optic neuritis. Immunogenetics 1990;31:278-80.
74. Hillert J, Leng C, Olerup O. No association with germ line T cell receptor β-chain gene alleles or haplotypes in Swedish patients with multiple sclerosis. J Neuroimmunol 1991;32: 141-7.
75. Martínez-Naves E, Victoria-Gutiérrez M, Uría DF, et al. The germline repertoire of T cell receptor β-chain genes in multiple sclerosis patients from Spain. J Neuroimmunol 1993; 47:9-13.
76. Beall SS, Biddison WE, McFarlin DE, et al. Susceptibility for multiple sclerosis is determined, in part, by inheritance of a 175-kb region of the TcR Vβ chain locus and HLA class II genes. J Neuroimmunol 1993;45:53-60.
77. Wei S, Charmley P, Birchfield RI, et al. Human T-cell receptor Vβ gene polymorphism and multiple sclerosis. Am J Hum Genet 1995;56:963-9.
78. Lynch SG, Rose JW, Petajan JH, et al. Discordance of T-cell receptor β-chain genes in familial multiple sclerosis. Ann Neurol 1991;30:402-10.
79. Seboun E, Robinson MA, Doolittle TH, et al. A susceptibility locus for multiple sclerosis is linked to the T cell receptor β chain complex. Cell 1989;57:1095-100.
80. Boylan KB, Takahashi N, Paty DW, et al. DNA length polymorphism 5′ to the myelin basic protein gene is associated with multiple sclerosis. Ann Neurol 1990;27:291-7.
81. Tienari PJ, Wikstrom J, Sajantila A, et al. Genetic susceptibility to multiple sclerosis is linked to the myelin basic protein gene. Lancet 1992;2:987-91.
82. Graham CA, Kirk CW, Nevin NC, et al. Lack of association between myelin basic protein gene microsatellite and multiple sclerosis. (Letter). Lancet 1993;341:1596.
83. Wood NW, Holmans P, Clayton D, et al. No linkage or association between multiple sclerosis and the myelin basic protein gene in affected sibling pairs. J Neurol Neurosurg Psychiatry 1994;57:1191-4.
84. Eoli M, Pandolfo M, Milanese C, et al. The myelin basic protein gene is not a major susceptibility locus for multiple sclerosis in Italian patients. J Neurol 1994;241:615-19.
85. Rose J, Gerken S, Lynch S, et al. Genetic susceptibility in familial multiple sclerosis not linked to the myelin basic protein gene. Lancet 1993;2:1179-81.
86. Link H, Tibbling G. Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis. Scand J Clin Lab Invest 1977;37:397-401.
87. Olsson T, Baig S, Hojeberg B, et al. Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis. Ann Neurol 1990;27:132-6.
88. Propert DN, Bernard CCA, Simons MJ. Gm allotypes and multiple sclerosis. J Immunogenet 1982;9:359-61.
89. Sandberg-Wollheim M, Baird LG, Schanfield M, et al. Association of CSF IgG concentration and immunoglobulin allotype in multiple sclerosis and optic neuritis. Clin Immunol Immunopathol 1984;31:212-21.
90. Sesboue R, Daveau M, Degos JD, et al. IgG (Gm) allotypes and multiple sclerosis in a French population: phenotype distribution and quantitative abnormalities in CSF with respect to sex, disease severity, and presence of intrathecal antibodies. Clin Immunol Immunopathol 1985;37:143-53.
91. Salier JP, Sesboue R, Martin-Mondiere C, et al. Combined influences of Gm and HLA phenotypes upon multiple sclerosis susceptibility and severity. J Clin Invest 1986;78: 533-8.
92. Francis DA, Brazier DM, Batchelor JR, et al. Gm allotypes in multiple sclerosis: influence susceptibility in HLA-DQw1-positive patients from the North-East of Scotland. Clin Immunol Immunopathol 1986;41:409-16.
93. Gaiser CN, Johnson MJ, de Lange G, et al. Susceptibility to multiple sclerosis associated with an immunoglobulin gamma 3 restriction fragment length polymorphism. J Clin Invest 1987;79:309-13.
94. Walter MA, Gibson WT, Ebers GC, et al. Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region. J Clin Invest 1991;87: 1266-73.
95. Hillert J. Immunoglobulin gamma constant gene region polymorphisms in multiple sclerosis. J Neuroimmunol 1993;43: 9-14.
96. Yu JS, Pandey JP, Massacesi L, et al. Segregation of immunoglobulin heavy chain constant region genes in multiple sclerosis sibling pairs. J Neuroimmunol 1993;42:113-16.
97. Selmaj K, Raine CS, Cannella B, et al. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 1991;87:949-54.
98. Sharief MK, Hentges R. Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis. N Engl J Med 1991;325:467-72.
99. Sharief MK, Thompson EJ. In vivo relationship of tumor necrosis factor-α to blood-brain barrier damage in patients with active multiple sclerosis. J Neuroimmunol 1992;38: 27-33.
100. Fugger L, Morling N, Sandberg-Wollheim M, et al. Tumor necrosis factor alpha gene polymorphism in multiple sclerosis and optic neuritis. J Neuroimmunol 1990;27:85-8.
101. Weinshenker BG, Liu Q, Schaid DJ, et al. Polymorphisms of the promoter region of the tumor necrosis factor α gene and the outcome of MS. (Abstract). J Neuroimmunol 1995; 62(Suppl 1):77.