Sequences in the proximal 5′ flanking region of the rat Neuron-Specific Enolase (NSE) gene are sufficient for cell type-specific reporter gene expression

Journal of Molecular Neuroscience

Volumn 8, Issue 1, 1997, Pages 63-73

  Twyman, Richard M ^a,b   Jones, Elizabeth A ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Chloramphenicol acetyltransferase; Enolase; Neuron; Promoter analysis; Transient transfection

Indexed keywords

CHOLINE ACETYLTRANSFERASE; ENOLASE;

ANIMAL; ARTICLE; FIBROBLAST; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HELA CELL; HUMAN; MOLECULAR GENETICS; NEUROBLASTOMA; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROMOTER REGION; RAT; REPORTER GENE; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CHOLINE O-ACETYLTRANSFERASE; FIBROBLASTS; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; PHOSPHOPYRUVATE HYDRATASE; PROMOTER REGIONS (GENETICS); RATS; TRANSFECTION;

EID: 0031067492     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02736864     Document Type: Article

References (33)

1. Batke J., Nazaryan K. B., and Karapetian N. H. (1988) Complex of brain D-phosphoglycerate mutase and γ-enolase and its reactivation by D-glycerate 2,3-bisphosphate. Arch. Biochem. Biophys. 264, 510-518.
2. Beaudet L., Charron G., Houle D., Tretjakoff I., Peterson A., and Julien P. (1992) Intragenic regulatory elements contribute to the transcriptional control of the neurofilament light gene. Gene (Amst.) 99, 127-204.
3. Brady S. T. and Lasek R. J. (1981) Nerve-specific enolase and creatine phosphokinase in axonal transport - soluble proteins and the axoplasmic matrix. Cell 23, 515-523.
4. Chen C. and Okayama H. (1987) High efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7, 2745-2751.
5. Chin L-S., Li L., and Greengard P. (1994) Neuron-specific expression of the synapsin II gene is directed by a specific core promoter and upstream regulatory elements. J. Biol. Chem. 266, 19,459-19,468.
6. Desmaris D., Fillon M., Lapointe L., and Royal A. (1992) Cell-specific transcription of the peripherin gene in neuronal cell lines involves a cis-acting element surrounding the TATA box. EMBO J. 11, 2971-2980.
7. Faraonio R., Minopoli G., Porcellini A., Costanzo F., Cimino F., and Russo T. (1994) The DNA sequence encompassing the transcriptional start site of a TATA-less promoter contains enough information to drive neuron-specific transcription. Nucleic Acids Res. 22, 4876-4883.
8. Forss-Petter S., Danielson P. E., and Sutcliffe J. G. (1986) Neuron-specific enolase: complete structure of the rat mRNA, multiple transcriptional start sites, and evidence suggesting posttranscriptional control. J. Neurosci. Res. 16, 141-156.
9. Forss-Petter S., Danielson P. E., Catsicas S., Battenberg E., Price J., Nerenberg M., and Sutcliffe J. G. (1990) Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 5, 187-197.
10. Gorman C. M., Moffat L. F., and Howard B. H. (1982) Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2, 1044-1051.
11. Greene L. A., Aletta J. M., Rukenstein A., and Greene S. H. (1987) PC12 pheochromocytoma cells: culture, nerve growth factor treatment, and experimental exploitation. Methods Enzymol. 147, 207-216.
12. Hsu C., Janicki S., and Montiero M. J. (1995) The first intron of the mouse neurofilament light gene (NF-L) increases gene expression. Mol. Brain Res. 32, 241-251.
13. Imagawa M., Chiu R., and Karin M. (1987) Transcription factor AP-2 mediates induction by two different signal transduction pathways: protein kinase C and cAMP. Cell 51, 251-260.
14. Lim L., Hall C., Leung T., Mahadevan L., and Whatley S. (1983) Neuron-specific enolase and creatine phosphokinase are protein components of rat brain synaptic plasma membranes. J. Neurochem. 41, 1177-1182.
15. Marangos P. J., Parma A. M., and Goodwin F. K. (1978) Functional properties of neuronal and glial isoenzymes of brain enolase. J. Nenrochem. 31, 727-732.
16. Marangos P. J. and Schmechel D. E. (1987) Neuron-specific enolase, a clinically useful marker for neurons and neuroendocrine cells. Ann. Rev. Neurosci. 10, 269-295.
17. Matranga V., Oliva D., Sciarrino S., D'Amelio L., and Giallongo A. (1993) Differential expression of neuron-specific enolase mRNA in mouse neuroblastoma cells in response to differentiation-inducing agents. Cell. Mol. Neurobiol. 13, 137-145.
18. Matsuo K., Ikeshima H., Shimoda K., Umezawa A., Hata J., Maejima K., Nojima H., and Takano T. (1993) Expression of the rat calmodulin gene II in the central nervous system: a 294 base promoter and 68 base leader segment mediates neuron-specific gene expression in transgenic mice. Mol. Brain Res. 20, 9-20.
19. Nedivi E., Basi G. S., Akey I. V., and Skene J. H. P. (1992) A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity. J. Neurosci. 12, 691-704.
20. Sakimura K., Kushiya E., Takahashi Y., and Suzuki Y. (1987) The structure and expression of the neuron-specific enolase gene. Gene (Amst.) 60, 103-113.
21. Sakimura K., Kushiya E., Ogura A., Kudo Y., Katagiri T., and Takahashi Y. (1995) Upstream and intron regulatory regions for expression of the rat neuron-specific enolase gene. Mol. Brain. Res. 28, 19-28.
22. Sambrook J., Fritsch E. F., and Maniatis T. (1989) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
23. Sauerwald A., Hoesche C., Oschwald R., and Kilimann M. W. (1990) The 5′ region of the synapsin I gene: a G+C-rich TATA- and CAAT-less, phylogenetically conserved sequence with cell type-specific promoter activity. J. Biol. Chem. 265, 14,932-14,937.
24. Takei N., Kondo J., Nagaike K., Ohsawa K., Kato K., and Kohsaka S. (1991) Neuronal survival factor from bovine brain is identical to neuron-specific enolase. J. Neurochem. 57, 1178-1184.
25. Tamura T. A., Sumita K., Hirose S., and Mikoshiba K. (1990) Core promoter of the mouse myelin basic protein gene governs brain-specific transcription in vitro. EMBO J. 9, 3101-3108.
26. Thiel G., Greengard P., and Südhof T. C. (1991) Characterization of tissue-specific transcription by the human synapsin I gene promoter. Proc. Natl. Acad. Sci. USA 88, 3431-3435.
27. Twyman R. M. and Jones E. A. (1995) The regulation of neuron-specific gene expression in the mammalian nervous system. J. Neurogenet. 10, 67-101.
28. Twyman R. M. and Jones E. A. The molecular biology of the vertebrate enolase family. Biochem. J., submitted for publication.
29. Vinores S. A., Marangos P. J., Parma A. M., and Guroff G. (1981) Increased levels of neuron-specific enolase in PC12 pheochromocytoma cells as a result of nerve growth factor treatment. J. Neurochem. 37, 597-600.
30. Wefald F. C., Devlin B. H., and Williams R. S. (1990) Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with cell-specific enhancer. Nature 344, 260-262.
31. Wisden W. and Grant A. L. (1996) Neuron-specific gene expression, in Molecular Biology of the Neuron (Davies R. W., and Morris B. J., eds.), βios Scientific Publishers, Oxford, in press.
32. Zimmerman L., Lendahl U., Cunningham M., McKay R., Parr B., Mann J., Vassileva G., and McMahon A. (1994) Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors. Neuron 12, 11-24.
33. Zomzely-Neurath C. E. (1983) Enolase, in Handbook of Neurochemistry, vol. 4, 2nd ed. (Lajtha A., ed.), Plenum, New York, pp. 402-433.