A novel functional polymorphism (-336A/G) in the promoter of the partitioning-defective protein-6α gene is associated with increased glucose tolerance and lower concentrations of serum non-esterified fatty acids

Diabetologia

Volumn 48, Issue 4, 2005, Pages 669-674

  Weyrich, P ^a   Lammers, R ^a   Fritsche, A ^a   MacHicao, F ^a   Haring H U ^a   Stefan, N ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Atypical protein kinase C; C2C12 cells; Glucose tolerance; NEFA; OGTT; Par6 protein; Reporter gene assay

Indexed keywords

FATTY ACID; GLUCOSE; LUCIFERASE; PARTITIONING DEFECTIVE PROTEIN 6ALPHA; PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; AGE DISTRIBUTION; ANIMAL CELL; ARTICLE; BODY FAT; CODON; CONTROLLED STUDY; DIABETES MELLITUS; EXON; FATTY ACID BLOOD LEVEL; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC CODE; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HOMOZYGOSITY; HUMAN; HYPERINSULINEMIA; INSULIN SENSITIVITY; INTRON; MAJOR CLINICAL STUDY; MALE; MOUSE; MYOBLAST; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; TRANSLATION INITIATION;

ADULT; ANIMALS; BASE SEQUENCE; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FATTY ACIDS, NONESTERIFIED; FEMALE; FIBROBLASTS; GENE FREQUENCY; GENOTYPE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HETEROZYGOTE; HOMOZYGOTE; HUMANS; HYPOGLYCEMIA; MALE; MICE; POLYMORPHISM, SINGLE NUCLEOTIDE; PPAR GAMMA; PROMOTER REGIONS (GENETICS); PROTEINS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 17844376539     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1688-4     Document Type: Article

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