메뉴 건너뛰기




Volumn 62, Issue 1, 2005, Pages 213-222

Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxic tumor cells

Author keywords

Enhancer; Genetic radiotherapy; HIF; Hypoxia; Radiation

Indexed keywords

CELLS; ENZYMES; MONOLAYERS; PATIENT TREATMENT; RADIOTHERAPY; TUMORS;

EID: 17844365829     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2005.01.031     Document Type: Article
Times cited : (19)

References (40)
  • 1
    • 0034989311 scopus 로고    scopus 로고
    • Biological consequences of tumor hypoxia
    • M. Hockel, P. Vaupel Biological consequences of tumor hypoxia Semin Oncol 28 2001 36 41
    • (2001) Semin Oncol , vol.28 , pp. 36-41
    • Hockel, M.1    Vaupel, P.2
  • 2
    • 0027963649 scopus 로고
    • Gene therapy targeted by radiation preferentially radiosensitizes tumor cells
    • R.R. Weichselbaum, D.E. Hallahan, M.A. Beckett Gene therapy targeted by radiation preferentially radiosensitizes tumor cells Cancer Res 54 1994 4266 4269
    • (1994) Cancer Res , vol.54 , pp. 4266-4269
    • Weichselbaum, R.R.1    Hallahan, D.E.2    Beckett, M.A.3
  • 3
    • 0029159918 scopus 로고
    • Spatial and temporal control of gene therapy using ionizing radiation
    • D.E. Hallahan, H.J. Mauceri, L.P. Seung Spatial and temporal control of gene therapy using ionizing radiation Nat Med 1 1995 786 791
    • (1995) Nat Med , vol.1 , pp. 786-791
    • Hallahan, D.E.1    Mauceri, H.J.2    Seung, L.P.3
  • 4
    • 0029777311 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature
    • H.J. Mauceri, N.N. Hanna, J.D. Wayne Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature Cancer Res 56 1996 4311 4314
    • (1996) Cancer Res , vol.56 , pp. 4311-4314
    • Mauceri, H.J.1    Hanna, N.N.2    Wayne, J.D.3
  • 5
    • 0029559345 scopus 로고
    • Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir
    • T. Joki, M. Nakamura, T. Ohno Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir Hum Gene Ther 6 1995 1507 1513
    • (1995) Hum Gene Ther , vol.6 , pp. 1507-1513
    • Joki, T.1    Nakamura, M.2    Ohno, T.3
  • 6
    • 1442332187 scopus 로고    scopus 로고
    • TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: A phase I study in patients with solid tumors
    • N. Senzer, S. Mani, A. Rosemurgy TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene A phase I study in patients with solid tumors J Clin Oncol 22 2004 592 601
    • (2004) J Clin Oncol , vol.22 , pp. 592-601
    • Senzer, N.1    Mani, S.2    Rosemurgy, A.3
  • 7
    • 4444295881 scopus 로고    scopus 로고
    • A Phase I trial of TNFerade biologic in patients with soft tissue sarcoma in the extremities
    • A.J. Mundt, S. Vijayakumar, J. Nemunaitis A Phase I trial of TNFerade biologic in patients with soft tissue sarcoma in the extremities Clin Cancer Res 10 2004 5747-5743
    • (2004) Clin Cancer Res , vol.10
    • Mundt, A.J.1    Vijayakumar, S.2    Nemunaitis, J.3
  • 8
    • 0030968939 scopus 로고    scopus 로고
    • Targeting gene expression to hypoxic tumor cells
    • G.U. Dachs, A.V. Patterson, J.D. Firth Targeting gene expression to hypoxic tumor cells Nat Med 3 1997 515 520
    • (1997) Nat Med , vol.3 , pp. 515-520
    • Dachs, G.U.1    Patterson, A.V.2    Firth, J.D.3
  • 9
    • 0034213449 scopus 로고    scopus 로고
    • Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells
    • N. Koshikawa, K. Takenaga, M. Tagawa Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells Cancer Res 60 2000 2936 2941
    • (2000) Cancer Res , vol.60 , pp. 2936-2941
    • Koshikawa, N.1    Takenaga, K.2    Tagawa, M.3
  • 10
    • 0036328116 scopus 로고    scopus 로고
    • Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumors
    • A.V. Patterson, K.J. Williams, R.L. Cowen Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumors Gene Ther 9 2002 946 954
    • (2002) Gene Ther , vol.9 , pp. 946-954
    • Patterson, A.V.1    Williams, K.J.2    Cowen, R.L.3
  • 11
    • 0037386279 scopus 로고    scopus 로고
    • Hypoxia-mediated tumor targeting
    • K. Binley, Z. Askham, L. Martin Hypoxia-mediated tumor targeting Gene Ther 10 2003 540 549
    • (2003) Gene Ther , vol.10 , pp. 540-549
    • Binley, K.1    Askham, Z.2    Martin, L.3
  • 12
    • 1242271216 scopus 로고    scopus 로고
    • Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: Reversing tumour radio-resistance and effecting cure
    • R.L. Cowen, K.J. Williams, E.C. Chinje Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy Reversing tumour radio-resistance and effecting cure Cancer Res 64 2004 1396 1402
    • (2004) Cancer Res , vol.64 , pp. 1396-1402
    • Cowen, R.L.1    Williams, K.J.2    Chinje, E.C.3
  • 13
    • 0024281381 scopus 로고
    • A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization
    • V.P. Sukhatme, X.M. Cao, L.C. Chang A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization Cell 53 1988 37 43
    • (1988) Cell , vol.53 , pp. 37-43
    • Sukhatme, V.P.1    Cao, X.M.2    Chang, L.C.3
  • 14
    • 0025317094 scopus 로고
    • Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals
    • X.M. Cao, R.A. Koski, A. Gashler Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals Mol Cell Biol 10 1990 1931 1939
    • (1990) Mol Cell Biol , vol.10 , pp. 1931-1939
    • Cao, X.M.1    Koski, R.A.2    Gashler, A.3
  • 15
    • 0026078126 scopus 로고
    • Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN
    • D.E. Hallahan, V.P. Sukhatme, M.L. Sherman Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN Proc Natl Acad Sci USA 88 1991 2156 2160
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2156-2160
    • Hallahan, D.E.1    Sukhatme, V.P.2    Sherman, M.L.3
  • 16
    • 0026452858 scopus 로고
    • Ionizing radiation activates transcription of the EGR1 gene via CArG elements
    • R. Datta, E. Rubin, V. Sukhatme Ionizing radiation activates transcription of the EGR1 gene via CArG elements Proc Natl Acad Sci USA 89 1992 10149 10153
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10149-10153
    • Datta, R.1    Rubin, E.2    Sukhatme, V.3
  • 17
    • 0034062266 scopus 로고    scopus 로고
    • Development of synthetic promoters for radiation-mediated gene therapy
    • B. Marples, S.D. Scott, J.H. Hendry Development of synthetic promoters for radiation-mediated gene therapy Gene Ther 7 2000 511 517
    • (2000) Gene Ther , vol.7 , pp. 511-517
    • Marples, B.1    Scott, S.D.2    Hendry, J.H.3
  • 18
    • 0032053169 scopus 로고    scopus 로고
    • Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression
    • P.J. Ratcliffe, J.F. O'Rourke, P.H. Maxwell Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression J Exp Biol 201 1998 1153 1162
    • (1998) J Exp Biol , vol.201 , pp. 1153-1162
    • Ratcliffe, P.J.1    O'Rourke, J.F.2    Maxwell, P.H.3
  • 19
    • 0028359320 scopus 로고
    • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase a genes: Similarities with the erythropoietin 3′ enhancer
    • J.D. Firth, B.L. Ebert, C.W. Pugh Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes Similarities with the erythropoietin 3′ enhancer Proc Natl Acad Sci USA 91 1994 6496 6500
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6496-6500
    • Firth, J.D.1    Ebert, B.L.2    Pugh, C.W.3
  • 20
    • 0029101515 scopus 로고
    • Hypoxic regulation of lactate dehydrogenase A: Interaction between hypoxia-inducible factor 1 and cAMP response elements
    • J.D. Firth, B.L. Ebert, P.J. Ratcliffe Hypoxic regulation of lactate dehydrogenase A Interaction between hypoxia-inducible factor 1 and cAMP response elements J Biol Chem 270 1995 21021 21027
    • (1995) J Biol Chem , vol.270 , pp. 21021-21027
    • Firth, J.D.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 21
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • G.L. Semenza, B.H. Jiang, S.W. Leung Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1 J Biol Chem 271 1996 32529 32537
    • (1996) J Biol Chem , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3
  • 22
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • J.A. Forsythe, B.H. Jiang, N.V. Iyer Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 Mol Cell Biol 16 1996 4604 4613
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3
  • 23
    • 0027461553 scopus 로고
    • Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism
    • P.H. Maxwell, C.W. Pugh, P.J. Ratcliffe Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines Evidence for a widespread oxygen-sensing mechanism Proc Natl Acad Sci USA 90 1993 2423 2427
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2423-2427
    • Maxwell, P.H.1    Pugh, C.W.2    Ratcliffe, P.J.3
  • 24
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • H. Zhong, A.M. De Marzo, E. Laughner Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases Cancer Res 59 1999 5830 5835
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 25
    • 0030787469 scopus 로고    scopus 로고
    • Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha: Modulation of transcriptional activity by oxygen tension
    • B.H. Jiang, J.Z. Zheng, S.W. Leung Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha Modulation of transcriptional activity by oxygen tension J Biol Chem 272 1997 19253 19260
    • (1997) J Biol Chem , vol.272 , pp. 19253-19260
    • Jiang, B.H.1    Zheng, J.Z.2    Leung, S.W.3
  • 26
    • 0030816109 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
    • P.H. Maxwell, G.U. Dachs, J.M. Gleadle Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth Proc Natl Acad Sci USA 94 1997 8104 8109
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8104-8109
    • Maxwell, P.H.1    Dachs, G.U.2    Gleadle, J.M.3
  • 27
    • 0033870727 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth
    • H.E. Ryan, M. Poloni, W. McNulty Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth Cancer Res 60 2000 4010 4015
    • (2000) Cancer Res , vol.60 , pp. 4010-4015
    • Ryan, H.E.1    Poloni, M.2    McNulty, W.3
  • 28
    • 0037050215 scopus 로고    scopus 로고
    • A protective role for HIF-1 in response to redox manipulation and glucose deprivation: Implications for tumorigenesis
    • K.J. Williams, B.A. Telfer, R.E. Airley A protective role for HIF-1 in response to redox manipulation and glucose deprivation Implications for tumorigenesis Oncogene 21 2002 282 290
    • (2002) Oncogene , vol.21 , pp. 282-290
    • Williams, K.J.1    Telfer, B.A.2    Airley, R.E.3
  • 29
    • 0033591346 scopus 로고    scopus 로고
    • Hypoxia-associated induction of early growth response-1 gene expression
    • S.F. Yan, J. Lu, Y.S. Zou Hypoxia-associated induction of early growth response-1 gene expression J Biol Chem 274 1999 15030 15040
    • (1999) J Biol Chem , vol.274 , pp. 15030-15040
    • Yan, S.F.1    Lu, J.2    Zou, Y.S.3
  • 30
    • 0036773458 scopus 로고    scopus 로고
    • Novel chimeric gene promoters responsive to hypoxia and ionizing radiation
    • O. Greco, B. Marples, G.U. Dachs Novel chimeric gene promoters responsive to hypoxia and ionizing radiation Gene Ther 9 2002 1403 1411
    • (2002) Gene Ther , vol.9 , pp. 1403-1411
    • Greco, O.1    Marples, B.2    Dachs, G.U.3
  • 31
    • 0036007293 scopus 로고    scopus 로고
    • Expression of HIF-1alpha by human macrophages: Implications for the use of macrophages in hypoxia-regulated cancer gene therapy
    • B. Burke, N. Tang, K.P. Corke Expression of HIF-1alpha by human macrophages Implications for the use of macrophages in hypoxia-regulated cancer gene therapy J Pathol 196 2002 204 212
    • (2002) J Pathol , vol.196 , pp. 204-212
    • Burke, B.1    Tang, N.2    Corke, K.P.3
  • 32
    • 0032478271 scopus 로고    scopus 로고
    • A simplified system for generating recombinant adenoviruses
    • T.C. He, S. Zhou, L.T. da Costa A simplified system for generating recombinant adenoviruses Proc Natl Acad Sci USA 95 1998 2509 2514
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2509-2514
    • He, T.C.1    Zhou, S.2    Da Costa, L.T.3
  • 33
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • H. Tian, S.L. McKnight, D.W. Russell Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells Genes Dev 11 1997 72 82
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 34
    • 0032189844 scopus 로고    scopus 로고
    • Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1alpha
    • M.S. Wiesener, H. Turley, W.E. Allen Induction of endothelial PAS domain protein-1 by hypoxia Characterization and comparison with hypoxia-inducible factor-1alpha Blood 92 1998 2260 2268
    • (1998) Blood , vol.92 , pp. 2260-2268
    • Wiesener, M.S.1    Turley, H.2    Allen, W.E.3
  • 35
    • 0037270366 scopus 로고    scopus 로고
    • Dual induction of the Epo-Egr-TNFα plasmid in hypoxic colon adenocarcinoma produces tumor growth delay
    • R.H. Salloum, M.P. Saunders, H.J. Mauceri Dual induction of the Epo-Egr-TNFα plasmid in hypoxic colon adenocarcinoma produces tumor growth delay Am Surg 69 2003 24 27
    • (2003) Am Surg , vol.69 , pp. 24-27
    • Salloum, R.H.1    Saunders, M.P.2    Mauceri, H.J.3
  • 36
    • 0036852101 scopus 로고    scopus 로고
    • The organotypic multicellular spheroid is a relevant three-dimensional model to study adenovirus replication and penetration in human tumors in vitro
    • J. Grill, M.L.M. Lamfers, V.W. van Beusechem The organotypic multicellular spheroid is a relevant three-dimensional model to study adenovirus replication and penetration in human tumors in vitro Mol Ther 6 2002 609 614
    • (2002) Mol Ther , vol.6 , pp. 609-614
    • Grill, J.1    Lamfers, M.L.M.2    Van Beusechem, V.W.3
  • 37
    • 0033118983 scopus 로고    scopus 로고
    • Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
    • M. Ema, K. Hirota, J. Mimura Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia Their stabilization and redox signal-induced interaction with CBP/p300 EMBO J 18 1999 1905 1914
    • (1999) EMBO J , vol.18 , pp. 1905-1914
    • Ema, M.1    Hirota, K.2    Mimura, J.3
  • 38
    • 0033986948 scopus 로고    scopus 로고
    • Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha
    • P. Carrero, K. Okamoto, P. Coumailleau Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha Mol Cell Biol 20 2000 402 415
    • (2000) Mol Cell Biol , vol.20 , pp. 402-415
    • Carrero, P.1    Okamoto, K.2    Coumailleau, P.3
  • 39
    • 0034544555 scopus 로고    scopus 로고
    • Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation
    • S.J. Wei, A. Botero, K. Hirota Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation Cancer Res 60 2000 6688 6695
    • (2000) Cancer Res , vol.60 , pp. 6688-6695
    • Wei, S.J.1    Botero, A.2    Hirota, K.3
  • 40
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
    • B.J. Moeller, Y. Cao, C.Y. Li Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors Role of reoxygenation, free radicals, and stress granules Cancer Cell 5 2004 429 441
    • (2004) Cancer Cell , vol.5 , pp. 429-441
    • Moeller, B.J.1    Cao, Y.2    Li, C.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.