Functional studies of the 5′-untranslated region of human 5-HT 4 receptor mRNA

Biochemical Journal

Volumn 387, Issue 2, 2005, Pages 463-471

  Maillet, Marjorie ^a   Gastineau, Monique ^a   Buchet, Pascal ^a   Asselin Labat, Marie Liesse ^a   Morel, Eric ^a   Laverrière, Jean Noël ^b   Lompré, Anne Marie ^a   Fischmeister, Rodolphe ^a   Lezoualc'h, Frank ^a  

^a INSERM   (France)

^b CNRS   (France)

Author keywords

5 Untranslated region; 5 Hydroxytryptamine (serotonin); CAMP; MRNA; Nkx2.5; Transcriptional regulation

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL MEMBRANES; CYTOLOGY; GENES; MUTAGENESIS; PROTEINS;

CENTRAL NERVOUS SYSTEM; EXONS; HUMAN CELL LINES; RECEPTOR GENES;

RNA;

MESSENGER RNA; NK2 TRANSCRIPTION FACTOR RELATED 5; RIBONUCLEASE; SEROTONIN 4 RECEPTOR; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL FUNCTION; CELL LINE; CELL STRAIN COS7; CODON; CONTROLLED STUDY; EMBRYO; ENHANCER REGION; EXON; GENE ACTIVITY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN MOTIF; RAT; RECEPTOR INTRINSIC ACTIVITY; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; EXONS; GENE EXPRESSION REGULATION; HEART ATRIA; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN, 5-HT4; REGULATORY SEQUENCES, NUCLEIC ACID; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC;

EID: 17644393147     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040744     Document Type: Article

References (46)

1. Hoyer, D., Hannon, J. P. and Martin, G. R. (2002) Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav. 71, 533-554
2. Dumuis, A., Bouhelal, R., Sebben, M., Cory, R. and Bockaert, J. (1988) A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol. Pharmacol. 34, 880-887
3. 4 receptor ligands: applications and new prospects. J. Med. Chem. 46, 319-344
4. Hegde, S. S. and Eglen, R. M. (1996) Peripheral 5-HT4 receptors. FASEB J. 10, 1398-1407
5. Marchetti, E., Dumuis, A., Bockaert, J., Soumireu-Mourat, B. and Roman, F. S. (2000) Differential modulation of the 5-HT(4) receptor agonists and antagonist on rat learning and memory. Neuropharmacology 39, 2017-2027
6. 4 receptor: a novel therapeutic target for Alzheimer's disease? Curr. Alz. Res. 1, 82-86
7. 4 receptor and the amyloid precursor protein processing. Exp. Gerontol. 38, 159-166
8. Robert, S. J., Zugaza, J. L., Fischmeister, R., Gardier, A. M. and Lezoualc'h, F. (2001) The human serotonin 5-HT4 receptor regulates secretion of non-amyloidogenic precursor protein. J. Biol. Chem. 276, 44881-44888
9. Maillet, M., Robert, S. J., Cacquevel, M., Gastineau, M., Vivien, D., Bertoglio, J., Zugaza, J. L., Fischmeister, R. and Lezoualc'h, F. (2003) Crosstalk between Rap1 and Rac regulates secretion of sAPPα. Nat. Cell. Biol. 5, 633-639
10. Jahnel, U., Rupp, J., Ertl, R. and Nawrath, H. (1992) Positive inotropic response to 5-HT in human atrial but not in ventricular heart muscle. Naunyn Schmiedebergs Arch. Pharmacol. 346, 482-485
11. Schoemaker, R. G., Du, X. Y., Bax, W. A., Bos, E. and Saxena, P. R. (1993) 5-Hydroxytryptamine stimulates human isolated atrium but not ventricle. Eur. J. Pharmacol. 230, 103-105
12. Kaumann, A. J. (1991) 5-HT4-like receptors in mammalian atria. J. Neural. Transm. 34, 195-201
13. Ouadid, H., Seguin, J., Dumuis, A., Bockaert, J. and Nargeot, J. (1992) Serotonin increases calcium current in human atrial myocytes via the newly described 5-hydroxytryptamine4 receptors. Mol. Pharmacol. 41, 346-351
14. Yusuf, S., Al-Saady, N. and Camm, A. J. (2003) 5-Hydroxytryptamine and atrial fibrillation: how significant is this piece in the puzzle. J. Cardiovasc. Electrophysiol. 14, 209-214
15. Blondel, O., Gastineau, M., Dahmoune, Y., Langlois, M. and Fischmeister, R. (1998) Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. J. Neurochem. 70, 2252-2261
16. Claeysen, S., Sebben, M., Becamel, C., Bockaert, J. and Dumuis, A. (1999) Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Mol. Pharmacol. 55, 910-920
17. Bender, E., Pindon, A, van Oers, I., Zhang, Y. B., Gommeren, W., Verhasselt, P., Jurzak, M., Leysen, J. and Luyten, W. (2000) Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant. J. Neurochem. 74, 478-489
18. Mialet, J., Berque-Bestel, I., Eftekhari, P., Gastineau, M., Giner, M., Dahmoune, Y., Donzeau-Gouge, P., Hoebeke, J., Langlois, M., Sicsic, S. et al. (2000) Isolation of the serotoninergic 5-HT4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines. Br. J. Pharmacol. 129, 771-781
19. Vilaro, M. T., Domenech, T., Palacios, J. M. and Mengod, G. (2002) Cloning and characterization of a novel human 5-HT(4) receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT(4) receptor variants. Neuropharmacology 42, 60-73
20. Claeysen, S., Faye, P., Sebben, M., Lemaire, S., Bockaert, J., Dumuis, A. and Taviaux, S. (1997) Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31-q33 by in situ hybridization. Cytogenet. Cell Genet. 78, 133-140
21. Hiroi, T, Hayashi-Kobayashi, N., Nagumo, S., Ino, M., Okawa, Y., Aoba, A. and Matsui, H. (2001) Identification and characterization of the human serotonin-4 receptor gene promoter. Biochem. Biophys. Res. Commun. 289, 337-344
22. Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B. and Behr, J. P. (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. U.S.A. 92, 7297-7301
23. Schreiber, E., Matthias, P., Muller, M. M. and Schaffner, W. (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17, 6419-6423
24. Medhurst, A. D., Lezoualc'h, F., Fischmeister, R., Middlemiss, D. N. and Sanger, G. J. (2001) Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT(4) receptor in the central nervous system by TaqMan real time RT-PCR. Mol. Brain Res. 90, 125-134
25. Boukouvala, S., Price, N., Plant, K. E. and Sim, E. (2003) Structure and transcriptional regulation of the Nat2 gene encoding for the drug-metabolizing enzyme arylamine N-acetyltransferase type 2 in mice. Biochem. J. 375, 593-602
26. Stickeler, E., Fraser, S. D., Honig, A., Chen, A. L., Berget, S. M. and Cooper, T. A. (2001) The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. EMBO J. 20, 3821-3830
27. Quandt, K., Frech, K., Karas, H., Wingender, E. and Werner, T. (1995) MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 23, 4878-4884
28. Heinemeyer, T., Wingender, E., Reuter, I., Hermjakob, H., Kel, A. E., Kel, O. V., Ignatieva, E. V., Ananko, E. A., Podkolodnaya, O. A., Kolpakov, F. A. et al. (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res. 26, 362-370
29. Meijer, H. A. and Thomas, A. A. (2002) Control of eukaryotic protein synthesis by upstream open reading frames in the 5′-untranslated region of an mRNA. Biochem. J. 367, 1-11
30. Kaumann, A. J., Lynham, J. A. and Brown, A. M. (1996) Comparison of the densities of 5-HT4 receptors, beta 1- and beta 2-adrenoceptors in human atrium: functional implications. Naunyn Schmiedebergs Arch. Pharmacol. 353, 592-595
31. Cazzola, M. and Skoda, R. C. (2000) Translational pathophysiology: a novel molecular mechanism of human disease. Blood 95, 3280-3288
32. Zhu, Q. S., Chen, K. and Shih, J. C. (1995) Characterization of the human 5-HT2A receptor gene promoter. J. Neurosci. 15, 4885-4895
33. Smale, S. T. (1997) Transcription initiation from TATA-less promoters within eukaryotic protein-coding genes. Biochim. Biophys. Acta 1351, 73-88
34. Akazawa, H. and Komuro, I. (2003) Roles of cardiac transcription factors in cardiac hypertrophy. Circ. Res. 92, 1079-1088
35. Di Lisi, R., Millino, C., Calabria, E., Altruda, F., Schiaffino, S. and Ausoni, S. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac traponin I gene in vitro and in vivo. J. Biol. Chem. 273, 25371-25380
36. Schwartz, R. J. and Olson, E. N. (1999) Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription. Development 126, 4187-4192
37. Shiojima, I., Komuro, I., Mizuno, T., Aikawa, R., Akazawa, H., Oka, T., Yamazaki, T. and Yazaki, Y. (1996) Molecular cloning and characterization of human cardiac homeobox gene CSX1. Circ. Res. 79, 920-929
38. Chen, C. Y. and Schwartz, R. J. (1995) Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, Nkx-2.5. J. Biol. Chem. 270, 15628-15633
39. Durocher, D., Chen, C. Y., Ardati, A., Schwartz, R. J. and Nemer, M. (1996) The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Mol. Cell. Biol. 16, 4648-4655
40. Sepulveda, J. L., Belaguli, N., Nigam, V., Chen, C. Y., Nemer, M. and Schwartz, R. J. (1998) GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol. Cell. Biol. 18, 3405-3415
41. Sepulveda, J. L., Vlahopoulos, S., Iyer, D., Belaguli, N. and Schwartz, R. J. (2002) Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity. J. Biol. Chem. 277, 25775-25782
42. 2+-ATPaSe type 3 gene in endothelial cells is controlled by Ets-1 and Sp1. J. Biol. Chem. 277, 36471-36478
43. Sebastian, S., White, J. A. and Wilson, J. E. (1999) Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity. J. Biol. Chem. 274, 31700-31706
44. Parks, C. L. and Shenk, T. (1996) The serotonin 1A receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. J. Biol. Chem. 271, 4417-4430
45. 2C: complete cDNA, genomic structure, and alternatively spliced variant. Genomics 35, 551-561
46. Chiu, I. M., Touhalisky, K. and Baran, C. (2001) Multiple controlling mechanisms of FGF1 gene expression through multiple tissue-specific promoters. Prog. Nucleic Acid Res. Mol. Biol. 70, 155-174