Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum

Journal of Neurophysiology

Volumn 93, Issue 5, 2005, Pages 2841-2848

  Takeuchi, Tadayoshi ^a   Fujinami, Kaori ^a   Goto, Hiroto ^a   Fujita, Akikazu ^a   Taketo, Makoto M ^b   Manabe, Toshiya ^c   Matsui, Minoru ^c   Hata, Fumiaki ^a  

^a Osaka Prefecture University   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ATROPINE; CHOLINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; PHYSOSTIGMINE SALICYLATE; CHOLINE ACETYLTRANSFERASE; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROFILAMENT PROTEIN; SYNAPTOPHYSIN;

ACETYLCHOLINE RELEASE; ANALYSIS OF VARIANCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTRIC FIELD; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ILEUM; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KNOCKOUT MOUSE; MOUSE; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE; SMOOTH MUSCLE FIBER; STIMULATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COMPARATIVE STUDY; CYTOLOGY; ELECTROSTIMULATION; FEMALE; HISTOLOGY; IN VITRO STUDY; MALE; METABOLISM; METHODOLOGY; MOUSE MUTANT; NERVE CELL; NORTHERN BLOTTING; PHYSIOLOGY;

ACETYLCHOLINE; ANALYSIS OF VARIANCE; ANIMALS; ATROPINE; BLOTTING, NORTHERN; CHOLINE O-ACETYLTRANSFERASE; ELECTRIC STIMULATION; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; ILEUM; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCARINIC ANTAGONISTS; MYENTERIC PLEXUS; NEUROFILAMENT PROTEINS; NEURONS; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M4; RECEPTORS, MUSCARINIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYNAPTOPHYSIN;

EID: 17644371641     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00986.2004     Document Type: Article

References (36)

1. Coulson FR, Jacoby DB, and Fryer AD. Increased function of inhibitory neuronal M2 muscarinic receptors in trachea and ileum of diabetic rats. Br J Pharmacol 135: 1355-1362, 2002.
2. Dietrich C and Kilbinger H. Prejunctional M1 and postjunctional M3 muscarinic receptors in the circular muscle of the guinea-pig ileum. Naunyn Schmiedebergs Arch Pharmacol 351: 237-243, 1995.
3. Eglen RM, Hegde SS, and Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 48: 531-565, 1996.
4. + channel, SK3, in fibroblast-like cells forming gap junctions with smooth muscle cells in the mouse small intestine. J Pharmacol Sci 92: 35-42, 2003.
5. Fujita A, Takeuchi T, Saitoh N, Hanai J, and Hata F. Expression of Ca(2+)-activated K(+) channels, SK3, in the interstitial cells of Cajal in the gastrointestinal tract. Am J Physiol Cell Physiol 281: C1727-C1733, 2001.
6. Fukudome Y, Ohno-Shosaku T, Matsui M, Omori Y, Fukaya M, Tsubokawa H, Taketo MM, Watanabe M, Manabe T, and Kano M. Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling. Eur J Neurosci 19: 2682-2692, 2004.
7. Giraldo E, Monferini E, Ladinsky H, and Hammer R. Muscarinic receptor heterogeneity in guinea pig intestinal smooth muscle: binding studies with AF-DX 116. Eur J Pharmacol 141: 475-477, 1987.
8. Gomeza J, Shannon H, Kostenis E, Felder C, Zhang L, Brodkin J, Grinberg A, Sheng H, and Wess J. Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci USA 96: 1692-1697, 1999a.
9. Gomeza J, Zhang L, Kostenis E, Felder C, Bymaster F, Brodkin J, Shannon H, Xia B, Deng C, and Wess J. Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci USA 96: 10483-10488, 1999b.
10. Hamilton SE, Loose MD, Qi M, Levey AI, Hille B, McKnight GS, Idzerda RL, and Nathanson NM. Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc Natl Acad Sci USA 94: 13311-13316, 1997.
11. Hersch SM, Gutekunst CA, Rees HD, Heilman CJ, and Levey AI. Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies. J Neurosci 14: 3351-3363, 1994.
12. Karasawa H, Taketo MM, and Matsui M. Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4. Eur J Pharmacol 468: 15-19, 2003.
13. Kawashima K, Fujimoto K, Suzuki T, and Oohata H. Pharmacological differentiation of presynaptic M1 muscarinic receptors modulating acetylcholine release from postsynaptic muscarinic receptors in guinea-pig ileum. Gen Pharmacol 21: 17-21, 1990.
14. Kilbinger H, Dietrich C, and von Bardeleben RS. Functional relevance of presynaptic muscarinic autoreceptors. J Physiol (Paris) 87: 77-81, 1993.
15. Kilbinger H and Wessler I. Pre- and postsynaptic effects of muscarinic agonists in the guinea-pig ileum. Naunyn Schmiedebergs Arch Pharmacol 314: 259-266, 1980.
16. Levey AI. Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain. Life Sci 52: 441-448, 1993.
17. Matsui M, Motomura D, Fujikawa T, Jiang J, Takahashi S, Manabe T, and Taketo MM. Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J Neurosci 22: 10627-10632, 2002.
18. Matsui M, Motomura D, Karasawa H, Fujikawa T, Jiang J, Komiya Y, Takahashi S, and Taketo MM. Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci USA 97: 9579-9584, 2000.
19. Matsui M, Yamada S, Oki T, Manabe T, Taketo MM, and Ehlert FJ. Functional analysis of muscarinic acetylcholine receptors using knockout mice. Life Sci 75: 2971-2981, 2004.
20. Nakamura T, Matsui M, Uchida K, Futatsugi A, Kusakawa S, Matsumoto N, Nakamura K, Manabe T, Taketo MM, and Mikoshiba K. M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice. J Physiol 558: 561-575, 2004.
21. Nishiwaki H, Saitoh N, Nishio H, Takeuchi T, and Hata F. Possible role of potassium channels in mu-receptor-mediated inhibition and muscarinic autoinhibition in acetylcholine release from myenteric plexus of guinea pig ileum. Jpn J Pharmacol 82: 343-349, 2000.
22. Ogishima M, Kaibara M, Ueki S, Kurimoto T, and Taniyama K. Z-338 facilitates acetylcholine release from enteric neurons due to blockade of muscarinic autoreceptors in guinea pig stomach. J Pharmacol Exp Ther 294: 33-37, 2000.
23. Ohno-Shosaku T, Matsui M, Fukudome Y, Shosaku J, Tsubokawa H, Taketo MM, Manabe T, and Kano M. Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus. Eur J Neurosci 18: 109-116, 2003.
24. Saitoh N, Fujimoto R, Ishii T, Nishio H, Takeuchi T, and Hata F. Muscarinic autoinhibition and modulatory role of protein kinase C in acetylcholine release from the myenteric plexus of guinea pig ileum. Jpn J Pharmacol 74: 155-163, 1997.
25. Slutsky I, Wess J, Gomeza J, Dudel J, Parnas I, and Parnas H. Use of knockout mice reveals involvement of M2-muscarinic receptors in control of the kinetics of acetylcholine release. J Neurophysiol 89: 1954-1967, 2003.
26. Soejima O, Katsuragi T, and Furukawa T. Opposite modulation by muscarinic M1 and M3 receptors of acetylcholine release from guinea pig ileum as measured directly. Eur J Pharmacol 249: 1-6, 1993.
27. Somogyi GT and de Groat WC. Function, signal transduction mechanisms and plasticity of presynaptic muscarinic receptors in the urinary bladder. Life Sci 64: 411-418, 1999.
28. Starke K, Gothert M, and Kilbinger H. Modulation of neurotransmitter release by presynaptic autoreceptors. Physiol Rev 69: 864-989, 1989.
29. Takeuchi T, Fujita A, Roumy M, Zajac JM, and Hata F. Effect of 1DMe, a neuropeptide FF analog, on acetylcholine release from myenteric plexus of guinea pig ileum. Jpn J Pharmacol 86: 417-422, 2001.
30. Trendelenburg AU, Gomeza J, Klebroff W, Zhou H, and Wess J. Heterogeneity of presynaptic muscarinic receptors mediating inhibition of sympathetic transmitter release: a study with M2- and M4-receptor-deficient mice. Br J Pharmacol 138: 469-480, 2003.
31. Tzavara ET, Bymaster FP, Felder CC, Wade M, Gomeza J, Wess J, McKinzie DL, and Nomikos GG. Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry 8: 673-679, 2003.
32. Wess J. Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications. Annu Rev Pharmacol Toxicol 44: 423-450, 2004.
33. Yamada M, Miyakawa T, Duttaroy A, Yamanaka A, Moriguchi T, Makita R, Ogawa M, Chou CJ, Xia B, Crawley JN, Felder CC, Deng CX, and Wess J. Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature 410: 207-212, 2001.
34. Zhang W, Basile AS, Gomeza J, Volpicelli LA, Levey AI, and Wess J. Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice. J Neurosci 22: 1709-1717, 2002a.
35. Zhang W, Yamada M, Gomeza J, Basile AS, and Wess J. Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. J Neurosci 22: 6347-6352, 2002b.
36. Zhou H, Meyer A, Starke K, Gomeza J, Wess J, and Trendelenburg AU. Heterogeneity of release-inhibiting muscarinic autoreceptors in heart atria and urinary bladder: a study with M(2)- and M(4)-receptor-deficient mice. Naunyn Schmiedebergs Arch Pharmacol 365: 112-122, 2002.