Practical synthesis of an orally active CCR5 antagonist, 7-{4-[2-(Butoxy)-ethoxy]phenyl}-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino] methyl}phenyl)-1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxamide

Organic Process Research and Development

Volumn 9, Issue 2, 2005, Pages 168-173

  Ikemoto, Tomomi ^a   Ito, Tatsuya ^a   Nishiguchi, Atsuko ^a   Miura, Syotaro ^a   Tomimatsu, Kiminori ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 BROMO 4 (2 BUTOXYETHOXY)BENZENE; 4 [(4 BROMO 2 FORMYLPHENYL)(PROPYL)AMINO]BUTANOIC ACID; 7 [4 [2 (BUTOXY)ETHOXY]PHENYL] N [4 [[METHYL(TETRAHYDRO 2H PYRAN 4 YL)AMINO]METHYL]PHENYL] 1 PROPYL 2,3 DIHYDRO 1H 1 BENZAZEPINE 4 CARBOXAMIDE; BENZENE DERIVATIVE; BUTYRIC ACID DERIVATIVE; CARBONIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR5; DIMETHYLCARBONATE; METHOXIDE SODIUM; METHYL 7 BROMO 1 PROPYL 2,3 DIHYDRO 1H 1 BENZAZEPINE 4 CARBOXYLATE; SODIUM DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CLAISEN REARRANGEMENT; DRUG ACTIVITY; DRUG SYNTHESIS; ESTERIFICATION; MOLECULE; MOUTH; REACTION ANALYSIS; TECHNIQUE;

EID: 17444422562     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0497916     Document Type: Article

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