Process development of 4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]aniline dihydrochloride: A key intermediate for TAK-779, a small-molecule nonpeptide CCR5 antagonist

Organic Process Research and Development

Volumn 6, Issue 1, 2002, Pages 70-73

  Hashimoto, Hideo ^a   Ikemoto, Tomomi ^a   Itoh, Tatsuya ^a   Maruyama, Hideaki ^a   Hanaoka, Tadashi ^a   Wakimasu, Mitsuhiro ^b   Mitsudera, Hiroyuki ^a   Tomimatsu, Kiminori ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b Scientific Information Pharmaceutical Business Development   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 [N METHYL N (TETRAHYDROPYRAN 4 YL)AMINOMETHYL]ANILINE; 4 NITROBENZYLBROMIDE; AMINE; ANILINE DERIVATIVE; BROMINE DERIVATIVE; CHEMICAL COMPOUND; CHEMOKINE RECEPTOR CCR5; METHYLAMINE; N (4 NITROBENZYL) N (TETRAHYDROPYRAN 4 YL)AMINE; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; N METHYL N (TETRAHYDROPYRAN 4 YL)AMINE; REAGENT; RECEPTOR BLOCKING AGENT; TETRAHYDRO 4H PYRAN 4 ONE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; COMMERCIAL PHENOMENA; METHODOLOGY; REDUCTION; SYNTHESIS;

EID: 0036003915     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op010052o     Document Type: Article

References (20)