Synthesis and biological evaluation of S-[11C]methylated mercaptoimidazole piperazinyl derivatives as potential radioligands for imaging 5-HT1A receptors by positron emission tomography (PET)

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 48, Issue 4, 2005, Pages 301-315

  Garcia, Raquel ^a   Xavier, Catarina ^a   Paulo, António ^a   Santos, Isabel ^a   Kniess, Torsten ^b   Bergmann, R ^b   Wüst, Frank ^b  

^a INSTITUTO TECNOLÓGICO E NUCLEAR   (Portugal)

^b INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

Author keywords

5 HT1A receptors; Carbon 11; Mercaptoimidazoles; Piperazines; Positron emission tomography

Indexed keywords

ALKYLATION; BINDING ENERGY; CARBON; ELECTRONS; POSITRONS;

1-METHYLIMIDAZOLE; 5-HT1A RECEPTOR; BIOLOGICAL EVALUATION; BRAIN UPTAKE; CARBON-11; MERCAPTOIMIDAZOLE; METHYLIMIDAZOLE; PIPERAZINE; RADIOLIGANDS; SYNTHESIS EVALUATION;

POSITRON EMISSION TOMOGRAPHY;

1 [4 [(2 METHOXYPHENYL) 1 PIPERAZINYL]BUTYL] 2 THIOMETHYLIMIDAZOLE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; CARBON 11; IMIDAZOLE DERIVATIVE; KETANSERIN; MERCAPTOIMIDAZOLE; METHYL [4 [(2 METHOXYPHENYL) 1 PIPERAZINYL]BUTYL](2 THIOMETHYL 1 METHYLIMIDAZOL 5 YL)METHANAMIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; PRAZOSIN; RADIOLIGAND; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; ISOTOPE LABELING; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RECEPTOR BINDING; SYNTHESIS;

EID: 17444420276     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.924     Document Type: Article

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