A nuclear receptor ligand down-regulates cytosolic phospholipase A 2 expression to reduce bile acid-induced cyclooxygenase 2 activity in cholangiocytes: Implications of anticarcinogenic action of farnesoid X receptor agonists

Digestive Diseases and Sciences

Volumn 50, Issue 3, 2005, Pages 514-524

  Komichi, Daisuke ^a   Tazuma, Susumu ^a   Nishioka, Tomoji ^a   Hyogo, Hideyuki ^a   Chayama, Kazuaki ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Cytoprotection; Glycochenodeoxycholate; GW4064; Prostaglandin

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY] PHENYL]VINYL]BENZOIC ACID; 3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; BILE ACID; CELL NUCLEUS RECEPTOR; CYCLOOXYGENASE 2; FARNESOID X RECEPTOR; FARNESOID X RECEPTOR BLOCKING AGENT; GLYCOCHENODEOXYCHOLIC ACID; LIGAND; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; RECEPTOR BLOCKING AGENT; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BILE ACID METABOLISM; BILE DUCT; CARCINOGENIC ACTIVITY; CELL IMMORTALIZATION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; HEPATOBILIARY SYSTEM; INCUBATION TIME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BILE ACIDS AND SALTS; BILIARY TRACT; BLOTTING, WESTERN; CELLS, CULTURED; DOWN-REGULATION; GENE EXPRESSION REGULATION; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PROBABILITY; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

EID: 17444390461     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-2467-2     Document Type: Article

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