Graft-versus-leukemia effect in allogeneic marrow transplant recipients with acute leukemia is maintained using cyclosporin A combined with methotrexate as prophylaxis

Bone Marrow Transplantation

Volumn 18, Issue 5, 1996, Pages 921-929

  Ringden O ^a   Labopin, M ^b   Gluckman, E ^c   Reiffers, J ^d   Vernant, J P ^e   Jouet, J P ^f   Harrousseau, J L ^g   Fiere, D ^h   Bacigalupo, A ⁱ   Frassoni, F ⁱ   Gorin, N C ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b HÔPITAL SAINT ANTOINE   (France)

^c SAINT LOUIS HOSPITAL   (France)

^d HAUT LÉVÊQUE HOSPITAL   (France)

^e HENRI MONDOR HOSPITAL   (France)

^f Hôpital   (France)

^g HÔTEL DIEU   (France)

^h EDOUARD HERRIOT HOSPITAL   (France)

ⁱ UNIVERSITY OF GENOA   (Italy)

Author keywords

Cyclosporin A; GVL; Methotrexate

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTARABINE; MELPHALAN; METHOTREXATE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CHILD; FEMALE; GRAFT VERSUS HOST REACTION; HLA MATCHING; HUMAN; LEUKEMIA REMISSION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROBABILITY; RELAPSE; SIBLING; SURVIVAL;

ADOLESCENT; ADULT; BONE MARROW TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; CYCLOSPORINE; DRUG THERAPY, COMBINATION; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; LEUKEMIA; METHOTREXATE; MIDDLE AGED; RECURRENCE; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 0345206680     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Weiden PL, Flournoy N, Thomas ED et al. Antileukemic effect of graft-versus-host disease in human recipients of allogeneic marrow grafts. New Engl J Med 1979; 300: 1068-1073.
2. Weiden PL, Sullivan KM, Flournoy N et al. Antileukemic effect of chronic graft-versus-host disease. Contribution to improved survival after allogeneic marrow transplantation. New Engl J Med 1981; 304: 1529-1533.
3. Horowitz MM, Gale RP, Sondel PM et al. Graft-versus-leukemia reactions following bone marrow transplantation in humans. Blood 1989; 175: 555-562.
4. Gale RP, Horowitz MM, Biggs JC et al. Transplant or chemotherapy in acute myelogenous leukaemia. Lancet 1989; 1: 1119-1122.
5. Fefer A, Sullivan KM, Weiden P et al. Graft-versus-leukemia effect in man: the relapse rate of acute leukemia is lower after allogeneic than after syngeneic marrow transplantation. In: Truitt RL, Gale RP, Bortin MM (eds). Cellular Immunotherapy of Cancer. AR Liss: New York, 1987, pp 401-408.
6. Ringdén O, Zwaan FE, Hermans J, Gratwohl A for the Leukemia Working Party of the European Group for Bone Marrow Transplantation. European experience of bone marrow transplantation for leukemia. Transplant Proc 1987; 19: 2600-2604.
7. Storb R, Deeg HJ, Whitehead J et al. Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft-versus-host disease after marrow transplantation for leukemia. New Engl J Med 1986; 314: 729-735.
8. Ringdén O, Horowitz MM, Sondel P et al. Methotrexate, cyclosporine or both to prevent graft-versus-host disease after HLA-identical sibling bone marrow transplants for early leukemia? Blood 1993; 81: 1094-1101.
9. Aschan J, Ringdén O, Sundberg B et al. Methotrexate combined with cyclosporine A decreases graft-versus-host disease, but increases leukemic relapse compared to monotherapy. Bone Marrow Transplant 1991; 7: 113-119.
10. Weaver CH, Hansen JA, Martin PO et al. Effect of graft-versus-host disease prophylaxis on relapse in patients transplanted for acute myeloid leukemia. Bone Marrow Transplant 1994; 14: 885-893.
11. Kaplan EI, Meier P. Non-parametric estimation for incomplete observations. J Am Stat Assoc 1958; 53: 457-481.
12. Cox DR. Regression models and life tables. J R Stat Soc Ser B 1972; 34: 187-220.
13. Thomas ED, Storb R, Clift RA, Fefer A et al. Bone-marrow transplantation I and II. New Engl J Med 1975; 292: 832-843, 895-902.
14. Shulman HM, Sullivan KM, Weiden PL et al. Chronic graft-versus-host syndrome in man: a clinicopathological study of 20 long-term Seattle patients. Am J Med 1980; 69: 204-217.
15. Ringdén O. Management of graft-versus-host disease. Eur J Haematol 1993; 51: 1-12.
16. Storb R, Prentice RL, Sullivan KM et al. Predictive factors in chronic graft-versus-host disease in patients with aplastic anemia treated by marrow transplantation from HLA-identical siblings. Ann Intern Med 1983; 98: 461-466.
17. Ringdén O, Paulin T, Lönnqvist B, Nilsson B. An analysis of factors predisposing to chronic graft-versus-host disease. Exp Hematol 1985; 13: 1062-1067.
18. Gratwohl A, Hermans J, Apperley J et al. Acute graft-versus-host disease: Grade and outcome in patients with chronic myelogenous leukemia. Blood 1995; 86: 813-818.
19. Fefer A, Einstein AB Jr, Cheever MA. Adoptive chemoimmunotherapy of cancer in animals: a review of results, principles and problems. Ann NY Acad Sci 1976; 277: 492-504.
20. Sullivan KM, Weiden PL, Storb R et al. Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia. Blood 1989; 73: 1720-1728.
21. Bacigalupo A, Van Lint MT, Occhini D et al. Increased risk of leukemia relapse with high-dose cyclosporine A after allogeneic marrow transplantation for acute leukemia. Blood 1991; 77: 1423-1428.
22. Aschan J, Ringdén O, Andström E et al. Individualized prophylaxis against graft-versus-host disease in leukemic marrow transplant recipients. Bone Marrow Transplant 1994; 14: 79-87.
23. Santos WG. Workshop Summary: Preparative regimens for allogeneic bone marrow transplantation in leukemia. In: RP Gale, R Champlin (eds). Progress in Bone Marrow Transplantation. AR Liss: New York, 1987, pp 113-119.
24. Clift RA, Buckner CD, Appelbaum FR et al. Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens. Blood 1990; 76: 1867-1871.
25. Buckner CD, Clift RA, Appelbaum FR et al. Effects of treatment regimens in patients allografted for acute and chronic myelogenous leukemia. Bone Marrow Transplant 1991; 7 (Suppl. 2): 6.