The endothelial cell protein receptor: A two-faced receptor, between coagulation and inflammation;Le récepteur endothélial à la protéine C (EPCR): Un récepteur à l'interface entre coagulation et système inflammatoire

Hematologie

Volumn 7, Issue 6, 2001, Pages 418-428

  Gandrille, Sophie ^a   Saposnik, Béatrice ^a   Aiach, Martine ^a  

^a INSERM   (France)

Author keywords

Coagulation; Endothelial cell receptor (EPCR); Inflammation; Inhibitor; Thrombomodulin

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; CELL ADHESION MOLECULE; CELL RECEPTOR; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOLIPID; PROTEIN C; PROTEIN S; PROTHROMBIN; THROMBIN; THROMBOMODULIN;

ANIMAL MODEL; BLOOD CLOTTING; ENDOTHELIUM CELL; GENE STRUCTURE; GENETIC TRANSCRIPTION; INFLAMMATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVIEW;

EID: 17344395431     PISSN: 12647527     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (47)

1. The protein C anticoagulant system: Inherited defects as a basis for venous thrombosis
2. The role of protein C and thrombomodulin in the regulation of blood coagulation
3. High affinity binding sites for activated protein C and protein C on cultured human umbilical vein endothelial cells. Independent of protein S and distinct from known ligands
4. Deficiency of protein C in congenital thrombotic disease
5. Thrombomodulin
6. Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor
7. Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: Comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains
8. Structural prediction and analysis of endothelial cell protein C/activated protein C receptor
9. The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor
10. Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR
11. Nucleotide structure and characterization of the murine gene encoding the endothelial cell protein C receptor
12. Organization and chromosomal localization of the human endothelial protein C receptor gene
13. Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo
14. One single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR)
15. Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway
16. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor
17. The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endathelial cells in arteries, veins, and capillaries
18. Characterization and regulation of the 5′-flanking region of the murine endothelial protein C receptor gene
19. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
20. Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation
21. Endothelial cell protein C receptor plays an important role in protein C activalion in vivo
22. Tafi, or plasma carboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomoduline complex
23. Expression and anticoagulant function of the endothelial cell protein C receptor (EPCR) in cancer cell lines
24. Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner
25. Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor: Implications for a novel mode of ligand recognition by an MHC class 1-type receptor
26. The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C
27. The Gla26 residue of protein C is required for the binding of protein C to factor Va
28. Identification of functional endothelial protein C receptor in human plasma
29. Mechanisms by which soluble endothelial cell pratein C receptar modulates protein C and activated pratein C function
30. The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors
31. The soluble endathelial protein C receptor binds to activated neutraphils: Invalvement of proteinase-3 and CD11b/CD18
32. Metalloprotealytic release of endothelial cell protein C receptor
33. A model for thrombin protection against endotoxin
34. Protein C prevents the caagulopathic and lethal effects of Escherichia coli infusion in the baboon
35. C4b-binding protein exacerbates the host response to Escherichia coli
36. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis
37. Selective effects of protein C activation of human monocytes by lipopolysaccharide, interferon-gamma, or PMA, modulation of effects on CD11b and CD14 but not CD25 or CD54 induction
38. Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: Treatment with protein C concentrate
39. Treatment of purpura fulminans in meningococcemia with protein C concentrate
40. An update on clinical and basic aspects of the protein C anticoagulant pathway
41. Efficacity and safety of recombinant human activated protein C for severe sepsis
42. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
43. Targeted disruption of the endothelial protein C receptor (EPCR) causes early lethality in mice
44. Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system
45. Direct detection of activated protein C in blood from human subjects
46. Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes
47. A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function