Positional ordering of reacting groups contributes significantly to the efficiency of proton transfer at an antibody active site

Journal of the American Chemical Society

Volumn 127, Issue 4, 2005, Pages 1307-1312

  Seebeck, Florian P ^a   Hilvert, Donald ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CATALYSTS; ENZYMES; HYDROPHOBICITY; MUTAGENESIS; PROTONS;

CATALYTIC ANTIBODY; CATALYTIC RESIDUE; PROTON ABSTRACTION; PROTON TRANSFER;

PARTICLE ACCELERATORS;

ALANINE; ASPARTIC ACID; CARBOXYLIC ACID; CATALYTIC ANTIBODY; CHIMERIC ANTIBODY; FORMIC ACID; GLUTAMINE; GLYCINE; PROTON;

ANTIBODY COMBINING SITE; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); COVALENT BOND; MATHEMATICAL ANALYSIS; MATHEMATICAL COMPUTING; MOLECULAR WEIGHT; MUTAGENESIS; PROTON TRANSPORT; SEQUENCE HOMOLOGY;

ANIMALS; ANTIBODIES, CATALYTIC; BINDING SITES; ESCHERICHIA COLI; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN FRAGMENTS; ISOXAZOLES; KINETICS; MICE; MUTAGENESIS, SITE-DIRECTED; NITRILES; PROTEIN ENGINEERING; PROTONS; RECOMBINANT FUSION PROTEINS; THERMODYNAMICS;

EID: 13644271603     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja044647l     Document Type: Article

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