Sports pharmacology and ergogenic aids

Primary Care - Clinics in Office Practice

Volumn 32, Issue 1, 2005, Pages 277-292

  Ellender, Lee ^a   Linder, Michael M ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; ANABOLIC AGENT; ANDROSTENEDIONE; ARGININE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA HYDROXY BETA METHYLBUTYRATE; BICARBONATE; BUTYRIC ACID DERIVATIVE; CAFFEINE; COCAINE; CREATININE; EPHEDRINE; GROWTH HORMONE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LYSINE; METANDIENONE; NICOTINE; ORNITHINE; PHENYLPROPANOLAMINE; PRASTERONE; PSEUDOEPHEDRINE; RECOMBINANT ERYTHROPOIETIN; STEROID; TAMOXIFEN; TESTOSTERONE; UNCLASSIFIED DRUG;

ACNE; AGGRESSION; ALOPECIA; ATHLETE; BLOOD TRANSFUSION; BLOOD VISCOSITY; CLITORIS; DEPRESSION; DIET SUPPLEMENTATION; DOPING; DRUG USE; EUPHORIA; FATIGUE; GASTROINTESTINAL DISEASE; GYNECOMASTIA; HISTORY; HUMAN; HYPERTENSION; HYPOMANIA; LIBIDO DISORDER; MANIA; MEDICAL SOCIETY; MENSTRUAL IRREGULARITY; MICTURITION DISORDER; MUSCLE CRAMP; PARANOIA; PHYSICAL PERFORMANCE; PRESCRIPTION; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; REVIEW; SPORT; TESTIS ATROPHY; THROMBOSIS;

EID: 17044389836     PISSN: 00954543     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pop.2004.11.008     Document Type: Review

References (108)

1. A. Pipe, and C. Ayotte Nutritional supplements and doping Clin J Sport Med 12 4 2002 245 249
2. F.T. Delbeke, P.V. Eenoo, and W.V. Thuyne Prohormone and sport J Steroid Biochem Mol Biol 83 2003 245 251
3. W.N. Taylor The first fifty years Macho medicine: a history of the anabolic steroid epidemic 1991 McFarland Jefferson (NC) 3 16
4. R.H. Strauss, and T.J. Curry Magic, science and drugs R.H. Strauss Drugs and performance in sports medicine 1987 W.B. Saunders Philadelphia 3 9
5. V.G. Laties, and B. Weiss The amphetamine margin in sports Fed Proc 40 12 1981 2689 2692
6. H. Thomason Drugs and the athlete B. Davies G. Thomas Science and sporting performance: management or manipulation? 1982 Oxford University Press Oxford (UK) 100 110
7. R. Voy, and K. Deeter Glory Years Drugs, sport, and politics 1991 Leisure Press Champaign (IL) 3 11
8. J.C. Wagner Enhancement of athletic performance with drugs an overview Sports Med 12 4 1991 250 265
9. M.D. Silver Use of ergogenic aids by athletes J Am Acad Orthop Surg 9 1 2001 61 70
10. I. Waddington Sport, health and drugs a critical sociological perspective 2000 E&FN SPON Rutledge, New York p. 170-86
11. P.M. Clarkson, and H.S. Thompson Drugs and sport Sports Med 24 1997 366 384
12. G.A. Fleming The FDA, regulation and the risk of stroke N Engl J Med 343 25 2000 1886 1887
13. L.L. Spriet Caffeine M.S. Bahrke C.E. Yesalis Performance-enhancing substances in sport and exercise 2002 Human Kinetics Champaign (IL) 267 268
14. T.E. Graham Caffeine and exercise metabolism, endurance and performance Sports Med 31 11 2001 785 807
15. B. Weiss, and U.G. Laties Enhancement of human performance by caffeine and the amphetamines Pharmacol Rev 14 1962 1 36
16. T.E. Graham, E. Hibbert, and P. Sathasivam Metabolic and exercise endurance effects of coffee and caffeine ingestion J Appl Physiol 85 1998 883 889
17. J. Sawynok, and T.L. Yaksh Caffeine as an analgesic adjuvant. A review of pharmacology and mechanisms of action Pharmacol Rev 45 1993 43 85
18. K. Collomp, S. Ahmaid, and J.C. Chatard Benefits of caffeine ingestion on sprint performance in trained and untrained swimmers Eur J Appl Physiol 64 1992 377 380
19. J. Le Blanc, M. Jobin, and J. Cote Enhanced metabolic response to caffeine in exercise-trained human subjects J Appl Physiol 59 1985 832 837
20. T.E. Grahm, and L.L. Spriet Metabolic, catecholamine, and exercise performance responses to various doses of caffeine J Appl Physiol 78 1995 867 874
21. G.A. Wadler, and B. Hainline Drugs and the athlete 1999 FA Davies Company Philadelphia p. 107-13
22. Hitler's final days recalled by physician Am Med News October 11, 1985 14
23. R.H. Strauss Anabolic steroids R.H. Strauss Drugs and performance in sports medicine 1987 WB Saunders Philadelphia 59 68
24. W.N. Taylor The search for medical applications Macho medicine: a history of the anabolic steroid epidemic 1991 McFarland Jefferson (NC) 17 23
25. P. Grunding, and M. Bachmann World anabolic review 1996 1995 M.B. Muscle Books Houston, TX p. 6-15
26. American College of Sports Medicine Position statement on the use and abuse of anabolic-androgenic steroids in sports Med Sci Sports 9 4 1977 xi xii
27. American College of Sports Medicine Position statement on the use and abuse of anabolic-androgenic steroids in sports Sports Medicine Bulletin 19 1984 13 18
28. C.E. Yesalis, and M.S. Bahrke Anabolic-androgenic steroids and related substances Curr Sports Med Rep 1 4 2002 246 252
29. S. Bhasin, T.W. Storer, and N. Berman The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men N Engl J Med 335 1 1996 1 7
30. J.G. Blue, and J.A. Lombardo Steroids and steroid-like compounds Clin Sports Med 18 3 1999 667 689
31. W.N. Taylor The period of false dogma Macho medicine: a history of the anabolic steroid epidemic 1991 McFarland Jefferson (NC) 24 33
32. R.O. Voy, and K.D. Deeter Beyond humanity Drugs, sport, and politics 1991 Leisure Press Champaign (IL) 13 33
33. L.D. Bowers Analytic advances in detection of performance-enhancing compounds Clin Chem 43 7 1997 1299 1304
34. D.H. Catlin, C.K. Hatton, and S.H. Starcevic Issues in detecting abuse of xenobiotic anabolic steroids and testosterone by analysis of athletes' urine Clin Chem 43 7 1997 1280 1288
35. W.N. Taylor The reclassification as Schedule III controlled substances Macho medicine: a history of the anabolic steroid epidemic 1991 McFarland Jefferson (NC) 39 65
36. E.C. Kutscher, B.C. Lund, and P.J. Perry Anabolic steroids a review for the clinician Sports Med 32 5 2002 285 296
37. Available at: www.nida.nih.gov/Infofax/steroids.html. Accessed October 4, 2003.
38. The NCAA Research Staff. NCAA study of substance use habits of college student-athletes. Presented to The National Collegiate Athetic Association Committee on Competitive Safeguards and Medical Aspects of Sports. Indianapolis, Indiana, May 23, 2001.
39. S. Ungerleider Faust's gold inside the East German doping machine 2001 Thomas Dunne Books New York p. 3-8
40. M. Parssinen, and T. Seppala Steroid use and long-term health risks in former athletes Sports Med 32 2 2002 83 94
41. S.A. Wemyss-Holden, F.C. Hamdy, and K.J. Hastie Steroid abuse in athletes, prostatic enlargement and bladder outflow obstruction - is there a relationship? Br J Urol 74 1994 476 478
42. F.C.W. Wu Endocrine aspects of anabolic steroids Clin Chem 43 7 1997 1280 1288
43. R.H. Strauss, and C.E. Yesalis Anabolic steroids in the athlete Annu Rev Med 42 1991 449 457
44. D.A. Seehusen, and J.E. Glorioso Tamoxifen as an ergogenic in women body builders Clin J Sport Med 12 5 2002 313 314
45. Pecci MA, Lombardo JA. Performance-enhancing supplements. Phys Med Rehabil Clin N Am 200; 11(4): 949-60.
46. T.L. Schwenk, and C.D. Costley When food becomes a drug: nonanabolic nutritional supplement use in athletes Am J Sports Med 30 6 2002 907 916
47. Z.N. Kenkare, and D.G. Federman Over-the-counter sports supplements: what clinicians need to know Compr Ther 28 2 2002 148 154
48. D.V. Gammeren, D. Falk, and J. Antonio The effects of supplementation with 19-nor-4-androstene-3, 17-dione and 19-nor-4-androstene-3,17-diol on body composition and athletic performance in previously weight-trained male athletes Eur J Appl Physiol 84 2001 426 431
49. P.R. Stricker Other ergogenic agents Clin Sports Med 17 2 1998 283 297
50. A.J. Morales, J.J. Nolan, and J.C. Nelson Effects of replacement dose dehydroepianrosterone in men and women of advancing age J Clin Endocrinol Metab 78 1994 1360 1367
51. M.E. Lawrence, and D.F. Kirby Nutrition and sports supplements J Clin Gastroenterol 35 4 2002 299 306
52. J.W. Fisher Erythropoietin: physiology and pharmacology update Exp Biol Med 228 2003 1 14
53. D.J. Shaskey, and G.A. Green Sports haematology Sports Med 29 1 2000 27 38
54. R.L. Wilber Detection of DNA-recombinant human epoetin-alfa as a pharmacological ergogenic aid Sports Med 32 2 2002 125 142
55. H.G. Klein Blood transfusion and athletics. Games people play N Engl J Med 312 13 1985 854 856
56. D.H. Catlin, and T.H. Murray Performance-enhancing drugs, fair competition, and olympic sport JAMA 276 3 1996 231 237
57. D.J. Armstrong, and T. Reilly Blood boosting and sport D.R. Mottran Drugs in Sport 3rd edition 2003 Routledge London and New York 205 225
58. S. Begley, and M. Brant The real scandal Newsweek February 15, 1999 48 54
59. D.E. Greydanus Sports doping in the adolescent athlete: the hope, hype and hyperbole Pediatr Clin North Am 49 4 2002 829 855
60. R.C. Harris, K. Soderlund, and E. Hultman Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation Clin Sci 83 3 1992 367 374
61. M. Gaie Olympic athletes face heat, other hurdles JAMA 276 3 1996 178 180
62. A.M. Persky, and G.A. Brazeau Clinical Pharmacology of the dietary supplement creatine monohydrate Pharmacol Rev 53 2 2001 161 176
63. T.W. Demant, and E.C. Rhodes Effects of creatine supplementation on exercise performance Sports Med 28 1 1999 49 60
64. E. Hultman, K. Soderlund, and J.A. Timmons Muscle creatine loading in men J Appl Physiol 81 1 1996 232 237
65. A. Casey, D. Constantine-Theodosine, and S. Howell Creatine ingestion favorable affects performance and muscle metabolism during maximal exercise in humans Am J Physiol 271 1 Pt. 1 1996 E31 E37
66. R. Birch, D. Noble, and P.L. Greenhaff The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man Eur J Appl Physiol Occup Physiol 69 3 1994 268 276
67. P.L. Greenhaff, K. Bodin, and K. Soderlund Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis Am J Physiol 266 5 Pt. 1 1994 E725 E730
68. A.L. Green, E. Hultman, and I.A. Macdonald Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans Am J Physiol 271 5 Pt. 1 1996 E821 E826
69. K. Vandenberghe, N. Gillis, and M. Van Leemputte Caffeine counteracts the ergogenic action of muscle creatine loading J Appl Physiol 80 2 1996 452 457
70. W.J. Kraemer, and J.S. Volek Cretinine supplementation. Its role in human performance Clin Sports Med 18 3 1999 651 666
71. R.B. Kreider, M. Ferreira, and M. Wilson Effects of creatine supplementation on body composition, strength, and sprint performance Med Sci Sports Exerc 30 1 1998 73 82
72. J.S. Volek, N.D. Duncan, and S.A. Mazetti Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training Med Sci Sports Exerc 31 8 1999 1147 1156
73. Juhn MS. Oral creatine supplementation. The physician and sports medicine. Available at: http://www.physsportsmed.com/issues/1999/05_99/juhn.htm. Accessed November 6, 2003.
74. R.B. Kreider Creatine, the next ergogenic supplement? Sports science training and technology Internet Society for Sport Science 1998 Available at: http://www.sportsci.org/traintech/creatine/rbk.html Accessed November 6, 2003
75. M. Greenwood, J. Farris, and R. Kreider Creatine supplementation patterns and perceived effects in select Division I collegiate athletes Clin J Sport Med 10 3 2000 191 194
76. N.R. Pritchard, and P.A. Kalra Renal dysfunction accompanying oral creatine supplements Lancet 351 9111 1998 1252 1253
77. K.M. Koshy, E. Griswold, and E.E. Schneeberger Interstitial nephritis in a patient taking creatine N Engl J Med 340 10 1999 814 815
78. R.L. Terjung, P. Clarkson, and E.R. Eichner The physiological and health effects of oral creatine supplementation Med Sci Sports Exerc 32 3 2000 706 717
79. T.A. McGuire, J.C. Sullivan, and D.A. Bernhardt Creatine supplementation in Wisconsin high school athletes WMJ 101 2 2002 25 30
80. K.E. Yarasheski Growth hormone effects on metabolism, body composition, muscle mass, and strength Exerc Sport Sci Rev 21 1994 285 312
81. S. Welle, C. Thornton, and M. Statt Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old J Clin Endocrinol Metab 81 9 1996 3239 3243
82. K.E. Yarasheski, J.A. Campbell, and K. Smith Effect of growth hormone and resistance exercise on muscle growth in young men Am J Physiol 262 3 Pt. 1 1992 E261 E267
83. D.R. Taaffe, L. Pruitt, and J. Reim Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men J Clin Endocrinal Metab 79 5 1994 1361 1366
84. K.E. Yarasheski, J.J. Zachwieja, and J.A. Cambell Effect of growth hormone and resistance exercise on muscle growth and strength in older men Am J Physiol 268 2 Pt. 1 1995 E268 E276
85. W.J. Kraemer, B.C. Nindl, and M.R. Rubin Growth hormone: physiological effects of exogenous administration M.S. Bahrke C.E. Yesalis Performance enhancing substances in sport and exercise 2002 Human Kinetics Champaign (IL) 65 78
86. K.A. Mossberg, and C. Peel Beta adrenergic antagonists M.S. Bahrke C.E. Yesalis Performance enhancing substances in sport and exercise 2002 Human Kinetics Champaign (IL) 149 156
87. P. Kaiser, B. Hylander, and K. Eliasson Effect of beta sensitive and nonselective beta blockade on blood pressure relative to physical performance in men with systemic hypertension Am J Cardiol 55 1985 79D 84D
88. N. Gordon, and J. Duncan Effect of beta blockers on exercise physiology: implications for exercise training Med Sci Sports Exerc 23 6 1991 668 676
89. H. Rusko, H. Kantola, and R. Luhtanen Effect of beta-blockade on performances requiring force, velocity, coordination and/or anaerobic metabolism J Sports Med Phys Fitness 20 1980 139 144
90. C. Robazza, Bortoli L., and V. Nougier Emotions, heart rate, and performance in archery J Sports Med Phys Fitness 39 1999 169 176
91. P. Helin, T. Sihuonen, and O. Hanninen Timing of the triggering action of shooting in relation to the cardiac cycle Br J Sports Med 2 1 1987 33 36
92. I. Waddington Sport, health and drugs: a critical sociological perspective 2000 E&FN Spon Rutledge, New York p. 114-34
93. N.F. Gordon, T.P. Van Rensburg, and H.M.S. Russell Effect of beta-adrenoceptor blockade and calcium antagonism, alone and in combination, on thermoregulation during prolonged exercise Int J Sports Med 8 1 1987 1 5
94. J.G. Macintyre Growth hormone and athletes Sports Med 4 2 1987 129 142
95. H.A. Haupt Anabolic steroids and growth hormone Am J Sports Med 21 3 1993 468 474
96. J.A. Chromiak, and J. Antonio Use of amino acids as growth hormone-realeasing agents by athletes Nutrition 18 7-8 2002 657 661
97. T.J. Marcell, D.R. Taaffe, and S.A. Hawkins Oral arginine does not stimulate basal or augment exercise-induced GH secretion in either young or old adults J Gerontol A Biol Sci Med Sci 53 8 1999 M395 M399
98. S. Nissen, R. Sharp, and M. Ray Effect of leucine metabolite β-methylbutyrate on muscle metabolism during resistance exercise training J Appl Physiol 81 5 1996 2095 2104
99. R.B. Kreider, M. Ferreira, and M. Wilson Effects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance training on markers of catabolism, body composition and strength Int J Sports Med 20 8 1999 503 509
100. J. Ransone, K. Neighbors, and Lefavir The effect of beta-hydroxy-beta- methylbutyrate on muscular strength and body composition in collegiate football players J Strength Cond Res 17 1 2003 34 39
101. L.G. Matson, and Z.V. Tran Effects of sodium bicarbonate imgestion on anaerobic performance Int J Sport Nutr 3 1 1993 2 28
102. S.R. Bird, J. Wiles, and J. Robbins The effect of sodium bicarbonate on 1500m racing time J Sports Sci 13 5 1995 399 403
103. J.R. Sutton, N.L. Jones, and C.L. Toews Effect of pH on muscle glycolysis during exercise Clin Sci 61 3 1981 331 338
104. J.C. Rupp, R.L. Bartels, and W. Zuelzer Effect of sodium bicarbonate ingestion on blood and muscle pH and exercise performance Med Sci Sports Exerc 15 2 1983 115
105. L. McNaughton, B. Dalton, and G. Palmer Sodium bicarbonate can be used as an ergogenic aid in high-intensity competitive cycle ergometry of 1 h duration Eur J Appl Physiol Occup Physiol 80 1 1999 64 69
106. M. Price, P. Moss, and S. Rance Effects of sodium bicarbonate ingestion on prolonged intermittent exercise Med Sci Sports Exerc 35 8 2003 1303 1308
107. L.R. McNaughton Bicarbonate ingestion: effects of dosage on 60 s cycle ergometry J Sports Sci 10 5 1992 415 423
108. L. McNaughton, K. Backx, and G. Palmer Effects of chronic bicarbonate ingestion on the performance of high-intensity work Eur J Appl Physiol Occup Physiol 80 4 1999 333 336