Nutrition and sports supplements: Fact or fiction

Journal of Clinical Gastroenterology

Volumn 35, Issue 4, 2002, Pages 299-306

  Lawrence, Marvin E ^a   Kirby, Donald F ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

Alternative medicine; Ergogenic aids; Sports supplements

Indexed keywords

AMINO ACID; ANDROSTENEDIONE; CHROMIUM; CREATINE; EPHEDRA EXTRACT; PROTEIN;

ALTERNATIVE MEDICINE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DIET SUPPLEMENTATION; EPHEDRA; GASTROINTESTINAL SYMPTOM; HUMAN; KIDNEY DISEASE; LIVER DISEASE; NUTRITION; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; REVIEW; WEIGHT REDUCTION;

ADOLESCENT; ADULT; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; NUTRITION PHYSIOLOGY; SPORTS;

EID: 0036784453     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004836-200210000-00005     Document Type: Review

References (66)

1. Sport supplement dangers. Consumer Reports 2001;June:40-2.
2. Sobal J, Marquart LF. Vitamin/mineral supplement use among high school athletes. Adolescence 1994;29:835-43.
3. Wadler GI, Hainlain B. Foundation of drug abuse in sports. In: Drugs and the athlete. Philadelphia: FA Davis Co., 1989:3-15.
4. Stephens M. Ergogenic aids: powders, pills and potions to enhance performance. Am Fam Physician 2001;63:842-3.
5. King DS, Sharp RL, Matthew DV, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men. JAMA 1999; 281:2020-8.
6. Mahesh VB, Greenblatt RB. The in vivo conversion of dehydroepiandosterone and androstenedione to testosterone in the human. Acta Endocrinol 1962;41: 400-6.
7. Brown GA, Vukovich MD, Reifenrath TA, et al. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 2000;10:340-59.
8. Balsom PD, Hultman E, Soderlund K, et al. Creatine supplementation and dynamic high intensity intermittent exercise. Scand J Med Sports 1993;3:143-9.
9. Balsom PD, Soderlund K, Sjodin B, et al. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatinine supplementation. Acta Physiol Scand 1995;1154:303-10.
10. Birch R, Noble D, Greenhaff PL. The influence of dietary creatinine supplementation on performance during repeated bouts of maximal isokinetic cycling in man. Eur J Appl Physiol 1994;69:268-70.
11. Bosco C, Tihanyi, Pucspk J, et al. Effect of oral creatine supplementation on jumping and running performance. Int J Sports Med 1997;18:368-72.
12. Casey A, Constantin-Teodosiu D, Howell S, et al. Creatine supplementation favorably affects performance and muscle metabolism during maximal intensity exercise in humans. Am J Physiol 1996;271:E31-7.
13. Dawson B, Cutler M, Moody A, et al. Effects of oral creatine loading on single and repeated maximal short sprints. Aust J Sci Med Sport 1995;27:56-61.
14. Earnest CP, Almada AL, Mitchell TL. Effects of creatine monohydrate ingestion on intermediate duration anaerobic treadmill running to exhaustion. J Strength Cond Res 1997;11:234-8.
15. Earnest CP, Almada AL, Mitchell TL, et al. The effect of creatine monohydrate on anaerobic power indices, muscular strength and body composition. Acta Physiol Scand 1995;153:207-9.
16. Gordon A, Hultman E, Kauser L. Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance. Cardiovasc Res 1995;30:413-8.
17. Greenhaff PL, Casey A, Short AH, et al. Influence of oral creatine supplementation on muscle torque during repeated bouts of voluntary exercise in man. Clin Sci 1993;84:565-71.
18. Harris RC, Viru M, Greenhaff PL, et al. The effect of oral creatine supplementation on running performance during maximal short term exercise in man. J Physiol 1993;467:74P.
19. Jacobs I, Bleue S, Goodman J. Creatine ingestion increases anaerobic capacity and maximum accumulated oxygen deficit. Can J Appl Physiol 1997;22:231-43.
20. Bloch K, Schoenheimer R. The biologic precursors of creatine. J Biol Chem 1941;138:167-94.
21. The American College of Sports Med roundtable on the physiologic and health effects of oral creatine supplementation. Med Sci Sports Exerc 2000;32:706-17.
22. Hoberman HD, Sims EA, Peters JH. Creatine and creatine metabolism in the normal adult male adult studied with the aid of isotropic nitrogen. J Biol Chem 1948;172:45-58.
23. Picou D, Reeds PJ, Jackson A, et al. The measurement of muscle mass in children using [15N] creatine. Pediatr Res 1976;10:184-8.
24. Bangsbo J, Gollnick PD, Graham TE, et al. Anaerobic energy production and oxygen deficit-debt relationship during exhaustive exercise in humans. J Physiol 1990;42:539-59.
25. Febbraio M, Flanagan R, Snow S, et al. Effect of creatine supplementation on intramuscular TCr, metabolism and performance during intermittent supramaximal exercise in humans. Acta Physiol Scand 1995;155:387-95.
26. Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 1992;83: 367-74.
27. Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7.
28. Balsom PD, Harridge SDR, Soderlund K, et al. Creatine supplementation per se does not enhance endurance exercise performance. Acta Physiol Scand 1993;149: 521-3.
29. Barnett CM, Hinds M, Jenkins DG. Effects of oral creatine supplementation on multiple sprint cycle performance. Aust J Sci Med Sport 1996;28:35-9.
30. Burke LM, Pyne DB, Teleford RD. Effect of oral creatine supplementation on single effort sprint performance in swimmers. Int J Sports Nutr 1996;6:222-33.
31. Cooke WH, Barnes WS. The influence of recovery duration on high intensity exercise performance after oral creatine supplementation. Can J Appl Physiol 1997;22:454-67.
32. Cooke WH, Grandjean PW, Barnes WS. Effect of oral creatine supplementation on power output and fatigue during bicycle ergometry. J Appl Physiol 1995;78: 670-3.
33. Mujika I, Chatard JC, Lacoste L, et al. Creatine supplementation does not improve sprint performance in competitive swimmers. Med Sci Sports Exerc 1996; 28:1435-41.
34. Vanderberie FB, Vandeneynde BM, Vandenberghe K, et al. Effect of creatine on endurance capacity and sprint power in cyclists. Int J Sports Med 1998;8: 2055-63.
35. Kreider RB, Ferreira M, Wilson M. Effects of creatine supplementation on body composition, strength, and sprint performance. Med Sci Sports Exerc 1998;30: 73-82.
36. Poortmans J, Francaux M. Long term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10.
37. Koshy K, Griswold E, Schneeberger E. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5.
38. Mihic S, Macdonald JR, Mckenzie S, et al. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine nor CK activity. Med Sci Sports Exerc 2000;32:291-6.
39. Peeters BM, Lantz CD, Mayhew JL. Effect of oral creatine monohydrate and creatine phosphate supplementation on maximal strength indices, body composition, and blood pressure. J Strength Cond Res 1999;13:3-9.
40. Groff JL, Gropper SS, Hunt SM. Macrominerals. In: Advanced nutrition and human metabolism. Minneapolis/St Paul: West Publishing Co., 1995:385-9.
41. Beltz S, Doering P. Efficacy of nutritional supplements used by athletes. Clin Pharm 1993;12:900-8.
42. Clarkson P. Effects of exercise on chromium levels: is supplementation required? Sports Med 1997;23:341-9.
43. Anderson RA, Polansky MM, Bryden NA, et al. Effect of exercise (running) on serum glucose, insulin, glucagon, and chromium excretion. Diabetes 1982;31: 212-6.
44. Anderson RA, Polansky MM, Bryden NA. Strenuous running: acute effects on chromium, copper, zinc, and selected clinical variables in urine and serum of male runners. Biol Trace Elem Res 1984;6:327-36.
45. Gatteschi L, Castellani W, Galvan P, et al. Effects of aerobic exercise on plasma chromium concentrations. In: Kies CV, Driskell JA, eds. Sports nutrition: minerals and electrolytes. Boca Raton: CRC Press. 1995:199-204.
46. Evans GW. The effect of chromium picolinate on insulin controlled parameters in humans. Int J Biosocial Med Res 1989;11:163-80.
47. Hasten DL, Rome EP, Franks BD. Effects of chromium picolinate on beginning weight training students. Int J Sport Nutr 1992;2:343-50.
48. Lukaski HC, Bolonchuk WW, Siders WA, et al. Chromium supplementation and resistance training: effects of body composition, strength, and trace element status of men. Am J Clin Nutr 1996;63:954-65.
49. Trent LK, Theiding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
50. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Am Pharm 1998;32:428-31.
51. Haller C, Benowitz N. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2001;343:1833-8.
52. Traub SJ, Hoyek W, Hoffman R: Case report. N Engl J Med 2001;344:1096.
53. Powell T, Hsu F, Turk J, et al. Ma-huang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis 1998;32:153-9.
54. Bruno A, Nolte KB, Chapin J. Stroke associated with ephedrine use. Neurology 1993;43:1313-6.
55. Canadians begin recall of dangerous drug supplement ephedra. Worst Pills Best Pills News 2002;7:10.
56. National Research Council. Recommended dietary allowances, 10th ed. Washington, DC: National Academy Press. 1989.
57. Rock CL. Nutrition in the older athlete. Clin Sports Med 1975;10:445-75.
58. Grandjean AC. Macronutrient intake of US athletes compared with the general population and recommendations made for athletes. Am J Clin Nutr 1989;49: 1070-6.
59. Faber M, Benade AJS. Nutrient uptake and dietary supplementation in body builders. S Afr Med J 1987;72:831-4.
60. Tarnopolsky MA, MacDougall JD, Atkinson SA. Influence of protein intake and training status on nitrogen balance and lean body mass. JAppl Physiol 1988;64: 187-93.
61. American Dietetic Association. Position of the American Dietetic Association and the Canadian Dietetic Association: nutrition for physical fitness and athletic performance for adults. J Am Diet Assoc 1993;93:691-6.
62. Kleiner SM. Performance-enhancing aids in sport: health consequences and nutritional alternatives. J Am Coll Nutr 1991;10:163-72.
63. Wilmore JH, Freund BJ. Nutritional enhancement of athletic performance. In: Winick M, ed. Nutrition and exercise. New York: Wiley, 1986:67-97.
64. Hecker AL. Nutrition and physical performance. In: Strauss RH, ed. Drugs and performance in sports, Philadelphia: WB Saunders Co., 1987:23-52.
65. Rasch PJ, Pierson WR. Effect of a protein dietary supplement on muscular strength and hypertrophy. Am J Clin Nutr 1962;11:530-2.
66. Kreik J. Performance-enhancing substances: what athletes are using. Clev Clin J Med 2001;68:283-302.