Structure of 9-amino-[N-(2-dimethylamino)propyl]-acridine-4-carboxamide bound to d(CGTACG)2: A comparison of structures of d(CGTACG) 2 complexed with intercalators in the presence of cobalt

Acta Crystallographica Section D: Biological Crystallography

Volumn 60, Issue 5, 2004, Pages 823-828

  Adams, Adrienne ^a   Guss, J Mitchell ^a   Denny, William A ^b   Wakelin, Laurence P G ^c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

9 AMINO (N (2 DIMETHYLAMINO)PROPYL)ACRIDINE 4 CARBOXAMIDE; 9-AMINO-(N-(2-DIMETHYLAMINO)PROPYL)ACRIDINE-4-CARBOXAMIDE; ACRIDINE DERIVATIVE; COBALT; GUANINE; HETERODUPLEX; INTERCALATING AGENT;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; CONFORMATION; HYDROGEN BOND; METABOLISM; X RAY CRYSTALLOGRAPHY;

ACRIDINES; COBALT; CRYSTALLOGRAPHY, X-RAY; GUANINE; HYDROGEN BONDING; INTERCALATING AGENTS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES;

EID: 16644400145     PISSN: 09074449     EISSN: None     Source Type: Journal    
DOI: 10.1107/S0907444904003907     Document Type: Article

References (26)

1. Adams, A., Guss, J. M., Collyer, C. A., Denny, W. A., Prakash, A. S. & Wakelin, L. P. G. (2000). Mol. Pharmacol. 58, 649-658.
2. Adams, A., Guss, J. M., Collyer, C. A., Denny, W. A. & Wakelin, L. P. G. (1999). Biochemistry, 38, 9221-9233.
3. Adams, A., Guss, J. M., Collyer, C. A., Denny, W. A. & Wakelin, L. P. G. (2000). Nucleic Acids Res. 28, 4244-1253.
4. Adams, A., Guss, J. M., Denny, W. A. & Wakelin, L. P. G. (2002). Nucleic Acids Res. 30, 719-725.
5. Atwell, G. J., Cain, B. F., Baguley, B. C., Finlay, G. J. & Denny, W. A. (1984). J. Med. Chem. 27, 1481-1485.
6. Berman, H. M., Olson, W. K., Beveridge, D. L., Westbrook, J., Gelbin, A., Demeny, T., Hsieh, S. H., Srinivasan, A. R. & Schneider, B. (1992). Biophys. J. 63, 751-759.
7. Collaborative Computational Project, Number 4 (1994). Acta Cryst. D50, 760-763.
8. Denny, W. A. (1997). Expert Opin. Investig. Drugs, 6, 1845-1851.
9. Denny, W. A., Atwell, G. J., Rewcastle, G. W. & Baguley, B. C. (1987). J. Med. Chem. 30, 658-663.
10. Denny, W. A., Roos, I. A. G. & Wakelin, L. P. G. (1986). Anti-Cancer Drug Des. 1, 141-147.
11. Fortune, J. M. & Osheroff, N. (2000). Prog. Nucleic Acid Res. Mol. Biol. 64, 221-253.
12. Lavery, R. & Sklenar, H. (1989). J. Biomol. Struct. Dyn. 6, 655-667.
13. Li, T. K. & Liu, L. F. (2001). Annu. Rev. Pharmacol. Toxicol. 41, 53-77.
14. Malonne, H. & Atassi, G. (1997). Anti-Cancer Drugs, 8, 811-822.
15. Neidle, S. & Parkinson, G. N. (2003). Curr. Opin. Struct. Biol. 13, 775-283.
16. Nitiss, J. L. (2002). Curr. Opin. Investig. Drugs, 3, 1512-1516.
17. Ortiz-Lombardia, M., Gonzalez, A., Eritja, R., Aymami, J., Azorin, F. & Coll, M. (1999). Nature Struct. Biol. 6, 913-917.
18. Otwinowski, Z. & Minor, W. (1997). Methods Enzymol. 276, 307-326.
19. Rewcastle, G. W., Atwell, G. J., Chambers, D., Baguley, B. C. & Denny, W. A. (1986). J. Med. Chem. 29, 472-477.
20. Sheldrick, G. M. (1997). The SHELX97 Manual. University of Göttingen, Germany.
21. Teixeira, S. C. M., Thorpe, J. H., Todd, A. K., Powell, H. R., Adams, A., Wakelin, L. P. G., Denny, W. A. & Cardin, C. J. (2002). J. Mol. Biol. 323, 167-171.
22. Thorpe, J. H., Hobbs, J. R., Todd, A. K., Denny, W. A., Charlton, P. & Cardin, C. J. (2000). Biochemistry, 39, 15055-15061.
23. Todd, A. K., Adams, A., Thorpe, J. H., Denny, W. A., Wakelin, L. P. G. & Cardin, C. J. (1999). J. Med. Chem. 42, 536-540.
24. Wakelin, L. P. G., Atwell, G. J., Rewcastle, G. W. & Denny, W. A. (1987). J. Med. Chem. 30, 855-861.
25. Wakelin, L. P. G., Bu, X., Eleftheriou, A., Parmar, A., Hayek, C. & Stewart, B. W. (2003). J. Med. Chem. 46, 5790-5802.
26. Yang, X.-L., Robinson, H., Gao, Y.-G. & Wang, A. H.-J. (2000). Biochemistry, 39, 10950-10957.