Comparative effects of estrogens plus androgens and tibolone on bone, lipid pattern and sexuality in postmenopausal women

Maturitas

Volumn 34, Issue 2, 2000, Pages 161-168

  Castelo Branco, Camil ^a   Vicente, Juan J ^a   Figueras, Francesc ^a   Sanjuan, Alex ^a   Martínez De Osaba, María J ^a   Casals, Elena ^a   Pons, Francesca ^a   Balasch, Juan ^a   Vanrell, Juan A ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

Androgens; Bone density; Estrogens; Lipids; Menopause; Replacement therapy; Sexuality; Tibolone

Indexed keywords

ANDROGEN; ANDROSTANEDIOL; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CHOLESTEROL; ESTRADIOL; ESTRADIOL VALERATE; ESTROGEN; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TIBOLONE; TRIACYLGLYCEROL;

ADULT; ARTICLE; BONE MASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HORMONE SUBSTITUTION; HUMAN; HYSTERECTOMY; LIPID METABOLISM; MAJOR CLINICAL STUDY; OSTEOPOROSIS; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; SEXUAL BEHAVIOR; X RAY ANALYSIS;

ADMINISTRATION, CUTANEOUS; ANABOLIC AGENTS; APOLIPOPROTEIN A-I; APOLIPOPROTEINS B; BONE AND BONES; BONE DENSITY; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DEHYDROEPIANDROSTERONE; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ESTROGENS, CONJUGATED (USP); FEMALE; FOLLOW-UP STUDIES; HUMANS; LIPIDS; MIDDLE AGED; NORPREGNENES; OSTEOPOROSIS, POSTMENOPAUSAL; POSTMENOPAUSE; PROSPECTIVE STUDIES; SEXUALITY; TRIGLYCERIDES;

EID: 0033973263     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5122(99)00096-1     Document Type: Article

References (39)

1. Castelo-Branco C., Pons F., Gonzalez-Merlo J. Bone mineral density in surgically postmenopausal women receiving hormonal replacement therapy as assessed by dual photon absorptiometry. Maturitas. 16:1993;133-137.
2. Lindsay R. Why do estrogens prevent bone loss? Baillieres. Clin. Obstet. Gynaecol. 5:1991;837-845.
3. Castelo-Branco C., Martinez de Osaba M.J., Pons F., Gonzalez-Merlo J. The effect of hormone replacement therapy on postmenopausal bone loss. Eur. J. Obstet. Gynaecol. Reprod. Biol. 44:1992;131-136.
4. Cauley J., Seely D., Ensrud K. et al. Estrogen replacement therapy and fractures in older women. Ann. Intern. Med. 122:1995;9-16.
5. Rozenberg S., Gevers R., Peretz A., Vandromme J., Robyn C., Ham H. Decrease of bone mineral density during estrogen substitution therapy. Maturitas. 17:1993;205-210.
6. Ginsburg J., Prelevic G., Butler D., Okolo S. Clinical experience with tibolone over 8 years. Maturitas. 21:1995;71-76.
7. Berning B., Kuijk C.V., Kuiper J.W., Bennink H.J., Kicovik P.M., Fauser B.C. Effects of two doses of tibolone on trabecular and cortical bone loss in early postmenopausal women: a two year randomized, placebo-controlled study. Bone. 19:1996;395-399.
8. Prelevic G.M., Bartram C., Wood J., Okolo S., Ginsburg J. Comparative effects on bone mineral density of tibolone, transdermal estrogen and oral estrogen-progestogen therapy in postmenopausal women. Gynecol. Endocrinol. 10:1996;413-420.
9. NAMS roundtable. Physiologic androgen replacement in menopausal women. Menopause Management 1998;7:26-28.
10. Davis S.R., McCloud P., Strauss B.J.G., Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas. 21:1995;227-236.
11. Dow M.G.T., Hart D.M., Forrest C.A. Hormonal treatments of sexual unresponsiveness in postmenopausal women: a comparative study. Br. J. Obstet. Gynaecol. 90:1983;361-366.
12. Sherwin B.B., Gelfand M.M., Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in surgical menopause. Psychosom. Med. 47:1985;339-351.
13. Sarvas M., Studd J.W.W., Fogelman I. et al. Skeletal effects of oral estrogen compared with subcutaneous estrogen and testosterone in postmenopausal women. Br. Med. J. 297:1988;331-333.
14. Watts N., Notelovitz M., Timmons C. et al. Comparison of oral estrogens and estrogens plus androgens on bone density, menopausal symptoms and lipo-protein profiles in surgical menopause. Obstet. Gynecol. 85:1995;529-537.
15. Morales A.J., Nolan J.J., Nelson J.C. et al. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J. Clin. Endocrinol. Metab. 78:1994;1360-1367.
16. Simon J., Kay G., Huh T., Shepanek M., Artis A., Wiita B. Cognitive function, mood and quality of life: Double blind comparison of estrogen and estrogen+androgen therapy in surgically menopausal women (abstract). Menopause. 4:1997;258-259.
17. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use the preparative ultracentrifuge. Clin. Chem. 18:1972;499-502.
18. Del Río L., Pons F., Huguet M., Setoain F.J., Setoain J. Anterioposterior versus lateral bone mineral density of spine assessed by dual X-ray absorptiometry. Eur. J. Nucl. Med. 22:1995;407-412.
19. Christiansen C., Christiansen S., McNair P., Hagen C. Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females. Eur. J. Clin. Invest. 10:1980;273-279.
20. Steinberg K.K., Freni-Titulear L.W., DePuey E.G. et al. Sex steroids and bone density in premenopausal and perimenopausal women. J. Clin. Endocrinol. Metab. 69:1989;533-539.
21. Nordin B.E.C., Robertson A., Seamrak R.F. et al. The relation between calcium absorption serum DHEA and vertebral mineral density in postmenopausal women. J. Clin. Endoc. Metab. 60:1985;651-657.
22. Taelman P., Kayman J.M., Janssens X. et al. Persistence of increased bone resorption and possible role of dehydroepiandrosterone as bone metabolism determinant in osteoporotic women in late menopause. Maturitas. 11:1989;65-73.
23. Longcope C., Franz C., Morello C. et al. Steroid and gonadotropin levels in women during the perimenopausal years. Maturitas. 8:1986;189-196.
24. Colvard D.S., Eriksen E.F., Keeting P.E. et al. Identification of androgen receptors in normal human osteoblast-like cells. Proc. Natl. Acad. Sci. USA. 86:1989;854-857.
25. Kasperk C.H., Wergedal J.E., Farley J.R. et al. Androgens directly stimulate proliferation of bone cells in vitro. Endocrinology. 124:1989;1576-1578.
26. Farish E., Fletcher C.D., Hart D.M. et al. The effects of hormone implants on serum lipoproteins and steroid hormones in bilateral oophorectomized women. Acta Endocrinol. 106:1984;116-120.
27. Notelovitz M., Gudat J.C., Ware M.D. et al. Lipids and lipoproteins in women after oophorectomy and the response to oestrogen therapy. Br. J. Obstet. Gynaecol. 90:1983;171-177.
28. Schaefer E.J., Foster D.M., Zech L.A. et al. The effects of estrogen administration on plasma lipoprotein metabolism in premenopausal females. J. Clin. Endocrinol. Metab. 57:1983;262-267.
29. Luciano A.A., Turksoy R.N., Carleo J., Hendrix J.W. Clinical and metabolic responses of menopausal women to sequential versus continuous estrogen and progestin replacement therapy. Obstet. Gynecol. 71:1988;39-43.
30. Cano A., Fernandes H., Serrano S., Mahiques P. Effect of continuous oestradiol-medroxyprogesterone administration on plasma lipids and lipoproteins. Maturitas. 13:1991;35-42.
31. Jensen J., Riis B.J., Ström V., Christiansen C. Long-term and withdrawal effects of two different oestrogen-progestogen combinations on lipid and lipoprotein profiles in postmenopausal women. Maturitas. 11:1989;117-128.
32. Yancey M.K., Hannan C.J., Plymate S.R., Stone I.K., Friendl K.E., Wright J.R. Serum lipids and lipoproteins in continuous or cyclic medroxyprogesterone acetate treatment in postmenopausal women treated with conjugated estrogens. Fertil. Steril. 54:1990;778-782.
33. Farish E., Fletcher C.D., Dagen M.M. et al. Lipoprotein and apolipoprotein levels in postmenopausal women on continuous oestrogen/progestogen therapy. Br. J. Obstet. Gynecol. 96:1989;358-364.
34. Hazzard W.R. Estrogen replacement and cardiovascular disease: serum lipids and blood pressure effects. Am. J. Obstet. Gynecol. 161 (Suppl.):1989;1847-1853.
35. Castelo-Branco C., Casals E., Sanllehy C., González-Merlo J., Iglesias X. Effect of oophorectomy and hormone replacement therapy on plasma lipids. Maturitas. 17:1993;113-122.
36. Castelo-Branco C., Casals E., Sanllehy C., Fortuny A., Vanrell J.A., González-Merlo J. Endometrium, plasma lipids, lipoproteins and apolipoproteins during postmenopausal estrogen replacement therapy with low doses of medroxiprogesterone acetate. J. Reprod. Med. 40:1995;305-311.
37. Castelo-Branco C., Casals E., Sanllehy C., Duran M. et al. Effects of progestogen on lipids, lipoproteins and apolipoproteins during transdermal hormone replacement therapy with and without medroxyprogesterone acetate. J. Reprod. Med. 41:1996;833-838.
38. Bush T.L., Miller V.T. Effects of pharmacologic agents used during menopause: impact on lipids and lipoproteins. Mishell D.R. Menopause: Physiology and Pharmacology. 1987;187-208 Medical Publishers Year Book, Chicago.
39. Morris N.M., Udry J.R., Khan-Dawood F., Dawood M.Y. Marital sex frequency and midcycle female testosterone. Arch. Sex. Behav. 16:1987;27-37.