Inhibition of MUC1 expression by indole-3-carbinol

International Journal of Cancer

Volumn 109, Issue 6, 2004, Pages 810-816

  Lee, Insong J ^a   Han, Feng ^a   Baek, Jin ^a   Hisatsune, Akinori ^a   Kim, Kwang Chul ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Cancer; Chemoprevention; Transcription

Indexed keywords

3 INDOLEMETHANOL; ESTROGEN RECEPTOR; LUCIFERASE; MUCIN 1;

ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER PREVENTION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; XENOBIOTIC METABOLISM;

ANTICARCINOGENIC AGENTS; BREAST NEOPLASMS; CA-15-3 ANTIGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGEN ANTAGONISTS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOLES; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; RNA, MESSENGER; SEQUENCE DELETION; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 16544387591     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20031     Document Type: Article

References (33)

1. Spicer AP, Rowse GJ, Lidner TK, Gendler SJ. Delayed mammary tumor progression in Muc-1 null mice. J Biol Chem 1995;270:30093-101.
2. Schroeder JA, Adriance MC, Thompson MC, Camenisch TD, Gendler SJ. MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion. Oncogene 2003;22:1324-32.
3. Li Y, Liu D, Chen D, Kharbanda, S, Kufe D. Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene 2003;22:6107-10.
4. Ligtenberg MJL, Kruijshaar L, Buijs F, van Meijer M, Litvinov SV, Hilkins J. Cell associated Episialin is a complex containing two proteins derived from a common precursor. J Biol Chem 1992;267:6171-7.
5. Parry S, Silverman HS, McDermott K, Willis A, Hollingsworth MA, Harris A. Identification of MUC1 proteolytic cleavage sites in vivo. Biochem Biophys Res Commun 2001;283:715-20.
6. Wesseling J, van der Valk SW, Vos HL, Sonnenberg A, Hilkens J. Episialin (MUC1) overexpression inhibits integrin-mediated cell-adhesion to extracellular-matrix components. J Cell Biol 1995;129:255-65.
7. Satoh S, Hinoda Y, Hayashi T, Burdick MD, Imai K, Hollingsworth MA. Enhancement of metastatic properties of pancreatic cancer cells by MUC1 gene encoding an anti-adhesion molecule. Int J Cancer 2000;88:507-18.
8. Agrawal B, Gendler SJ, Longenecker BM. The biological role of mucins in cellular interactions and immune regulation: prospects for cancer immunotherapy. Mol Med Today 1998;4:397-403.
9. Chan AK, Lockhart DC, von Bernstorff W, Spanjaard RA, Joo HG, Eberlein TJ, Goedegebuure PS. Soluble MUC1 secreted by human epithelial cancer cells mediates immune supression by blocking T-cell activation. Int J Cancer 1999;82:721-6.
10. Gendler SJ. MUC1, the renaissance molecule. J Mammary Gland Biol Neoplasia 2001;6:339-53.
11. Wen Y, Caffrey TC, Wheelock MJ, Johnson KR, and Hollingsworth MA. Nuclear association of the cytoplasmic tail of MUC1 and 13 β-catenin. J Biol Chem 2003;278:38029-39.
12. Gaemers IC, Vos HL, Volders HH, van der Valk SW, Hilkens J. A STAT-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells. J Biol Chem 2001;276:6191-9.
13. Abe M., Kufe D. Characterization of cis-acting elements regulating transcription of the human DF3 breast carcinoma-associated antigen (MUC1) gene. Proc Natl Acad Sci U S A 1993;90:282-6.
14. Kovarik A, Peat N, Wilson D, Gendler SJ, Taylor-Papadimitriou J. Analysis of the tissue-specific promoter of the MUC1 gene. J Biol Chem 1993;268:9917-26.
15. Lagow EL, Carson DD. Synergistic stimulation of MUC1 expression in normal breast epithelia and breast cancer cells by interferon-gamma and tumor necrosis factor-alpha. J Cell Biochem 2002;86:759-72.
16. Kovarik A, Lu PJ, Peat N, Morris J, Taylor-Papadimitriou J. Two GC boxes (Sp1 sites) are involved in regulation of the activity of the epithelium-specific MUC1 promoter. J Biol Chem 1996;271:18140-7.
17. Lee IJ, Hyun SW, Nandi A, Kim KC. Transcriptional regulation of the hamster Muc1 gene: identification of a putative negative regulatory element. Am J Physiol-Lung Cell Mol Physiol 2003;284:L160-8.
18. Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, de Herreros AG, Baulida J. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem 2002;277:39209-16.
19. Schmidt JV, Bradfield CA. Ah receptor signaling pathways. Annu Rev Cell Dev Biol 1996;12:55-89.
20. Safe S. Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicol Lett 2001;120:1-7.
21. Lillehoj EP, Han F, Kim KC. Mutagenesis of a Gly-Ser cleavage site in MUC1 inhibits ectodomain shedding. Biochem Biophys Res Commun 2003;307:743-9.
22. Schuebel KE, Bustelo XR, Nielsen DA, Song BJ, Barbacid M, Goldman D, Lee IJ. Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. Oncogene 1996;13:363-71.
23. Zaretsky JZ, Sarid R, Aylon Y, Mittelman LA, Wreschner DH, Keydar I. Analysis of the promoter of the MUC1 gene overexpressed in breast cancer. FEBS Lett 1999;461:189-95.
24. Whitlock JP Jr. Induction of cytochrome P4501A1. Annu Rev Pharmacol Toxicol 1999;39:103-25.
25. Cram EJ, Liu BD, Bjeldanes LF, Firestone GL. Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter. J Biol Chem 2001;276:22332-40.
26. Shertzer HG, Senft AP. The micronutrient indole-3-carbinol: implications for disease and chemoprevention. Drug Metabol Drug Interact 2000;17:159-88.
27. Brignall MS. Prevention and treatment of cancer with indole-3-carbinol. Altern Med Rev 2001;6:580-9.
28. Zhou X, DeSouza MM, Julian J, Gendler SJ, Carson DD. Estrogen receptor does not directly regulate the murine Muc-1 promoter. Mol Cell Endocrinol 1998;143:65-78.
29. Botti C, Seregni E, Lombardo C, Massaron S, Bombardieri E. Effects of steroid-free fetal serum and steroid supplementation on MUC1 gene expression in human breast cancer cell line MCF-7. Anticancer Res 1997;17:205-8.
30. Puga A, Barnes SJ, Dalton TP, Chang CY, Knudsen ES, Maier MA. Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J Biol Chem 2000;275:2943-50.
31. Cover CM, Hsieh SJ, Tran SH, Hallden G, Kim GS, Bjeldanes LF, Firestone GL. Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G(1) cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling. J Biol Chem 1998;273:3838-47.
32. Meng QH, Qi M, Chen DZ, Yuan RQ, Goldberg ID, Rosen EM, Auborn K, Fan SJ. Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J Mol Med 2000;78:155-65.
33. Wegner CC, Zhou X, Ding Z-M, Kuo MT, Carson DD. Tyrosine kinase inhibition decreases Muc-1 expression in mouse epithelial cells. J Cell Physiol 1997;170:200-8.