-
1
-
-
0032584083
-
The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death
-
Bazenet CE, Mota MA, Rubin LL. 1998. The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death. Proc Natl Acad Sci U S A 95:3984-3989.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 3984-3989
-
-
Bazenet, C.E.1
Mota, M.A.2
Rubin, L.L.3
-
2
-
-
0038554077
-
Biology of the p21-activated kinases
-
Bokoch GM. 2003. Biology of the p21-activated kinases. Annu Rev Biochem 72:743-781.
-
(2003)
Annu Rev Biochem
, vol.72
, pp. 743-781
-
-
Bokoch, G.M.1
-
3
-
-
0032698075
-
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
-
Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. 1999. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286:1358-1362.
-
(1999)
Science
, vol.286
, pp. 1358-1362
-
-
Bonni, A.1
Brunet, A.2
West, A.E.3
Datta, S.R.4
Takasu, M.A.5
Greenberg, M.E.6
-
4
-
-
0031873788
-
Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis
-
Borodezt K, D'Mello SR. 1998. Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis. J Neurosci Res 53:531-534.
-
(1998)
J Neurosci Res
, vol.53
, pp. 531-534
-
-
Borodezt, K.1
D'Mello, S.R.2
-
5
-
-
4043132339
-
Survival of cultured cerebellar granule neurons can be maintained by Akt-dependent and Akt-independent signaling pathways
-
in press
-
Chin PC, D'Mello SR. 2004. Survival of cultured cerebellar granule neurons can be maintained by Akt-dependent and Akt-independent signaling pathways. Brain Res Mol Brain Res (in press).
-
(2004)
Brain Res Mol Brain Res
-
-
Chin, P.C.1
D'Mello, S.R.2
-
6
-
-
3342974363
-
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism
-
Chin PC, Liu L, Morrison BE, Siddiq A, Ratan RR, Bottiglieri T, D'Mello SR. 2004. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem 90:595-608.
-
(2004)
J Neurochem
, vol.90
, pp. 595-608
-
-
Chin, P.C.1
Liu, L.2
Morrison, B.E.3
Siddiq, A.4
Ratan, R.R.5
Bottiglieri, T.6
D'Mello, S.R.7
-
7
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
8
-
-
0036897230
-
Dysregulation of glycogen synthase kinase-3beta signaling in hepatocellular carcinoma cells
-
Desbois-Mouthon C, Blivet-Van Eggelpoel MJ, Beurel E, Boissan M, Delelo R, Cadoret A, Capeau J. 2002. Dysregulation of glycogen synthase kinase-3beta signaling in hepatocellular carcinoma cells. Hepatology 36:1528-1536.
-
(2002)
Hepatology
, vol.36
, pp. 1528-1536
-
-
Desbois-Mouthon, C.1
Blivet-Van Eggelpoel, M.J.2
Beurel, E.3
Boissan, M.4
Delelo, R.5
Cadoret, A.6
Capeau, J.7
-
9
-
-
0027483920
-
Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
-
D'Mello SR, Galli C, Ciotti T, Calissano P. 1993. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc Natl Acad Sci U S A 90:10989-10993.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 10989-10993
-
-
D'Mello, S.R.1
Galli, C.2
Ciotti, T.3
Calissano, P.4
-
10
-
-
0031054670
-
Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: Possible involvement of PI 3-kinase in IGF-1 signaling
-
D'Mello SR, Borodezt K, Soltoff SP. 1997. Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling. J Neurosci 17:1548-1560.
-
(1997)
J Neurosci
, vol.17
, pp. 1548-1560
-
-
D'Mello, S.R.1
Borodezt, K.2
Soltoff, S.P.3
-
11
-
-
0033977687
-
Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium
-
D'Mello SR, Kuan CY, Flavell RA, Rakic P. 2000. Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium. J Neurosci Res 59:24-31.
-
(2000)
J Neurosci Res
, vol.59
, pp. 24-31
-
-
D'Mello, S.R.1
Kuan, C.Y.2
Flavell, R.A.3
Rakic, P.4
-
12
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665.
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
13
-
-
0034671936
-
p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-Ikappa B kinases NF-kappa B pathway and proinflammatory cytokines in Helicobacter pylori infection
-
Foryst-Ludwig A, Naumann M. 2000. p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-Ikappa B kinases NF-kappa B pathway and proinflammatory cytokines in Helicobacter pylori infection. J Biol Chem 275:39779-39785.
-
(2000)
J Biol Chem
, vol.275
, pp. 39779-39785
-
-
Foryst-Ludwig, A.1
Naumann, M.2
-
14
-
-
0030830220
-
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
-
Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH. 1997. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J 16:6426-6438.
-
(1997)
EMBO J
, vol.16
, pp. 6426-6438
-
-
Frost, J.A.1
Steen, H.2
Shapiro, P.3
Lewis, T.4
Ahn, N.5
Shaw, P.E.6
Cobb, M.H.7
-
15
-
-
0034733041
-
Stimulation of NF kappa B activity by multiple signaling pathways requires PAK-1
-
Frost JA, Swantek JL, Stippec S, Yin MJ, Gaynor R, Cobb MH. 2000. Stimulation of NF kappa B activity by multiple signaling pathways requires PAK-1. J Biol Chem 275:19693-19699.
-
(2000)
J Biol Chem
, vol.275
, pp. 19693-19699
-
-
Frost, J.A.1
Swantek, J.L.2
Stippec, S.3
Yin, M.J.4
Gaynor, R.5
Cobb, M.H.6
-
16
-
-
0034677861
-
Insulin-like growth factor-1-mediated protection from neuronal apoptosis is linked to phosphorylation of the pro-apoptotic protein BAD but not to inhibition of cytochrome c translocation in rat cerebellar neurons
-
Gleichmann M, Weller M, Schulz JB. 2000. Insulin-like growth factor-1-mediated protection from neuronal apoptosis is linked to phosphorylation of the pro-apoptotic protein BAD but not to inhibition of cytochrome c translocation in rat cerebellar neurons. Neurosci Lett 282:69-72.
-
(2000)
Neurosci Lett
, vol.282
, pp. 69-72
-
-
Gleichmann, M.1
Weller, M.2
Schulz, J.B.3
-
17
-
-
0035957986
-
The serine/threonine kinase PAK-4 prevents caspase activation and protects cells from apoptosis
-
Gnesutta N, Qu J, Minden A. 2001. The serine/threonine kinase PAK-4 prevents caspase activation and protects cells from apoptosis. J Biol Chem 276:14414-14419.
-
(2001)
J Biol Chem
, vol.276
, pp. 14414-14419
-
-
Gnesutta, N.1
Qu, J.2
Minden, A.3
-
18
-
-
0035853447
-
Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes
-
Hernandez R, Teruel T, Lorenzo M. 2001. Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes. FEBS Lett 494:225-231.
-
(2001)
FEBS Lett
, vol.494
, pp. 225-231
-
-
Hernandez, R.1
Teruel, T.2
Lorenzo, M.3
-
19
-
-
0036223236
-
p21-activated kinases: Three more join the Pak
-
Jaffer ZM, Chernoff J. 2002. p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol 34:713-717.
-
(2002)
Int J Biochem Cell Biol
, vol.34
, pp. 713-717
-
-
Jaffer, Z.M.1
Chernoff, J.2
-
20
-
-
0033986791
-
Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons
-
Kanamoto T, Mota M, Takeda K, Rubin LL, Miyazono K, Ichijo H, Bazenet CE. 2000. Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons. Mol Cell Biol 20:196-204.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 196-204
-
-
Kanamoto, T.1
Mota, M.2
Takeda, K.3
Rubin, L.L.4
Miyazono, K.5
Ichijo, H.6
Bazenet, C.E.7
-
21
-
-
0034731505
-
p21-activated kinase (PAK-1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1)
-
King CC, Gardiner EM, Zenke FT, Bohl BP, Newton AC, Hemmings BA, Bokoch GM. 2000. p21-activated kinase (PAK-1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem 275:41201-41209.
-
(2000)
J Biol Chem
, vol.275
, pp. 41201-41209
-
-
King, C.C.1
Gardiner, E.M.2
Zenke, F.T.3
Bohl, B.P.4
Newton, A.C.5
Hemmings, B.A.6
Bokoch, G.M.7
-
22
-
-
0036282745
-
Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery
-
Konishi Y, Lehtinen M, Donovan N, Bonni A. 2002. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell 9:1005-1016.
-
(2002)
Mol Cell
, vol.9
, pp. 1005-1016
-
-
Konishi, Y.1
Lehtinen, M.2
Donovan, N.3
Bonni, A.4
-
23
-
-
0035112978
-
NF-kappaB is involved in the survival of cerebellar granule neurons: Association of IkappaBbeta phosphorylation with cell survival
-
Koulich E, Nguyen T, Johnson K, Giardina C, D'Mello S. 2001. NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaBbeta phosphorylation with cell survival. J Neurochem 76:1188-1198.
-
(2001)
J Neurochem
, vol.76
, pp. 1188-1198
-
-
Koulich, E.1
Nguyen, T.2
Johnson, K.3
Giardina, C.4
D'Mello, S.5
-
24
-
-
0031443641
-
Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis
-
Lee N, MacDonald H, Reinhard C, Halenbeck R, Roulston A, Shi T, Williams LT. 1997. Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis. Proc Natl Acad Sci U S A 94:13642-13647.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 13642-13647
-
-
Lee, N.1
MacDonald, H.2
Reinhard, C.3
Halenbeck, R.4
Roulston, A.5
Shi, T.6
Williams, L.T.7
-
25
-
-
0035914433
-
An essential role for Rac/Cdc42 GTPases in cerebellar granule neuron survival
-
Linseman DA, Laessig T, Meintzer MK, McClure M, Barth H, Aktories K, Heidenreich KA. 2001. An essential role for Rac/Cdc42 GTPases in cerebellar granule neuron survival. J Biol Chem 276:39123-39131.
-
(2001)
J Biol Chem
, vol.276
, pp. 39123-39131
-
-
Linseman, D.A.1
Laessig, T.2
Meintzer, M.K.3
McClure, M.4
Barth, H.5
Aktories, K.6
Heidenreich, K.A.7
-
26
-
-
0028078824
-
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
-
Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367:40-46.
-
(1994)
Nature
, vol.367
, pp. 40-46
-
-
Manser, E.1
Leung, T.2
Salihuddin, H.3
Zhao, Z.S.4
Lim, L.5
-
27
-
-
0030797727
-
Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
-
Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmukh M, Korsmeyer SJ, Johnson EM Jr. 1997. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol 139:205-217.
-
(1997)
J Cell Biol
, vol.139
, pp. 205-217
-
-
Miller, T.M.1
Moulder, K.L.2
Knudson, C.M.3
Creedon, D.J.4
Deshmukh, M.5
Korsmeyer, S.J.6
Johnson Jr., E.M.7
-
28
-
-
0029166671
-
Rho, rac and Cdc42 GTPases: Regulators of actin structures, cell adhesion and motility
-
Nobes CD, Hall A. 1995. Rho, rac and Cdc42 GTPases: regulators of actin structures, cell adhesion and motility. Biochem Soc Trans 23:456-459.
-
(1995)
Biochem Soc Trans
, vol.23
, pp. 456-459
-
-
Nobes, C.D.1
Hall, A.2
-
29
-
-
0033570320
-
Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis
-
Padmanabhan J, Park DS, Greene LA, Shelanski ML. 1999. Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. Neuroscience 19:8747-8756.
-
(1999)
Neuroscience
, vol.19
, pp. 8747-8756
-
-
Padmanabhan, J.1
Park, D.S.2
Greene, L.A.3
Shelanski, M.L.4
-
30
-
-
0030918572
-
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK-2
-
Rudel T, Bokoch GM. 1997. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK-2. Science 276:1571-1574.
-
(1997)
Science
, vol.276
, pp. 1571-1574
-
-
Rudel, T.1
Bokoch, G.M.2
-
31
-
-
0040056864
-
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis
-
Schurmann A, Mooney AF, Sanders LC, Sells MA, Wang HG, Reed JC, Bokoch GM. 2000. p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol 20:453-461.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 453-461
-
-
Schurmann, A.1
Mooney, A.F.2
Sanders, L.C.3
Sells, M.A.4
Wang, H.G.5
Reed, J.C.6
Bokoch, G.M.7
-
32
-
-
0034673376
-
PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes
-
Smith U, Carvalho E, Mosialou E, Beguinot F, Formisano P, Rondinone C. 2002. PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytes. Biochem Biophys Res Commun 268:315-320.
-
(2002)
Biochem Biophys Res Commun
, vol.268
, pp. 315-320
-
-
Smith, U.1
Carvalho, E.2
Mosialou, E.3
Beguinot, F.4
Formisano, P.5
Rondinone, C.6
-
33
-
-
0034655467
-
Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition
-
Tanaka T, Tatsuno I, Uchida D, Moroo I, Morio H, Nakamura S, Noguchi Y, Yasuda T, Kitagawa M, Saito Y, Hirai A. 2000. Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. J Neurosci 20:2852-2859.
-
(2000)
J Neurosci
, vol.20
, pp. 2852-2859
-
-
Tanaka, T.1
Tatsuno, I.2
Uchida, D.3
Moroo, I.4
Morio, H.5
Nakamura, S.6
Noguchi, Y.7
Yasuda, T.8
Kitagawa, M.9
Saito, Y.10
Hirai, A.11
-
34
-
-
0037500256
-
Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition
-
Tran NH, Frost JA. 2003. Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition. J Biol Chem 278:11221-11226.
-
(2003)
J Biol Chem
, vol.278
, pp. 11221-11226
-
-
Tran, N.H.1
Frost, J.A.2
-
35
-
-
0032582669
-
Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity
-
Walter BN, Huang Z, Jakobi R, Tuazon PT, Alnemri ES, Litwack G, Traugh JA. 1998. Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. J Biol Chem 273:28733-28739.
-
(1998)
J Biol Chem
, vol.273
, pp. 28733-28739
-
-
Walter, B.N.1
Huang, Z.2
Jakobi, R.3
Tuazon, P.T.4
Alnemri, E.S.5
Litwack, G.6
Traugh, J.A.7
-
36
-
-
0037040291
-
Interaction between active PAK-1 and Raf-1 is necessary for phosphorylation and activation of Raf-1
-
Zang M, Hayne C, Luo Z. 2002. Interaction between active PAK-1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. J Biol Chem 277:4395-4405.
-
(2002)
J Biol Chem
, vol.277
, pp. 4395-4405
-
-
Zang, M.1
Hayne, C.2
Luo, Z.3
|