Biodegradable Triblock Copolymer of PLGA-PEG-PLGA Enhances Gene Transfection Efficiency

Pharmaceutical Research

Volumn 21, Issue 1, 2004, Pages 50-54

  Jeong, Ji Hoon ^a   Kim, Sung Wan ^a,b   Park, Tae Gwan ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Biodegradable; Excipient; Gene delivery; Nontoxic; PLGA PEG PLGA triblock copolymer

Indexed keywords

CATION; COPOLYMER; DNA; EXCIPIENT; LUCIFERASE; MACROGOL; PLASMID DNA; POLOXAMER; POLYETHYLENEIMINE; POLYGLACTIN;

ARTICLE; BIODEGRADABILITY; CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; EMBRYO; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ISOTOPE LABELING; PLASMID; PRIORITY JOURNAL; PRODUCTIVITY; QUANTITATIVE ANALYSIS;

BIOCOMPATIBLE MATERIALS; BIOTRANSFORMATION; CELL LINE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; HUMANS; LUCIFERASES; POLYETHYLENE GLYCOLS; POLYGLACTIN 910; TRANSFECTION;

EID: 1642579663     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000012151.05441.bf     Document Type: Article

References (24)

1. F. D. Ledley. Nonviral gene therapy: the promise of genes as pharmaceutical products. Hum. Gene Ther. 6:1129-1144 (1995).
2. A. Rolland and P. Felgner. (eds). Non-viral gene delivery systems. Adv. Drug Del. Rev. 30:1-227 (1998).
3. S. C. De Smedt, J. Demeester, and W. E. Hennink. Cation polymer based gene delivery systems. Pharm. Res. 17:113-126 (2000).
4. O. Boussif, F. Lezoualc'h, M. A, Zanta, M. D. Mergny, D. Scheman, B. Demeneix, and J. P. Behr. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. USA 92:7297-7303 (1995).
5. J. H. Jeong, S. H. Song, D. W. Lim, H. Lee, and T. G. Park. DNA Transfection Using Linear Poly(ethylenimine) Prepared by Controlled Acid Hydrolysis of Poly(2-ethyl-2-oxazoline). J. Control. Release 73:391-399 (2001).
6. R. J. Mumper, J. G. Duguid, K. Anwer, M. K. Barron, H. Nitta, and A. P. Rolland. Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle. Pharm. Res. 13:701-709 (1996).
7. P. L. Felgner, T. R. Gader, M. Holm, R. Roman, H. W. Chan, M. Wenz, J. P. Nerthrop, G. M. Ringold, and M. Danielsen. Lipofection: a highly efficient, lipid-mediated DNA transfection procedure. Proc. Natl. Acad. Sci. USA 84:7412-7417 (1987).
8. S. Han, R. I. Mahato, and S. W. Kim. Water-soluble lipopolymer for gene delivery. Bioconjug. Chem. 12:337-345 (2001).
9. Y. H. Choi, F. Liu, J. S. Park, and S. W. Kim. Lactose-poly(ethylene glycol)-grafted poly-L-lysine as hepatoma cell targeted gene carrier. Bioconjug. Chem. 9:708-718 (1998).
10. H. Lee, J. H. Jeong, and T. G. Park. PEG grafted polylysine with fusogenic peptide for gene delivery: high transfection efficiency with low cytotoxicity. J. Control. Release 79:283-291 (2002).
11. H. Lee, J. H. Jeong, and T. G. Park. A New Gene Delivery Formulation of polyethyleneimine/DNA complexes coated with PEG conjugated fusogenic peptide. J. Control. Release 76:138-192 (2001).
12. P. Lemieux, N. Guerin, G. Paradis, R. Proulx, L. Chistyakova, A. Kabanov, and V. Alakhov. A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle. Gene Ther. 7:986-991 (2000).
13. J. Liaw, S.-F. Chang, and F.-C. Hsiao. In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide) -poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles. Gene Ther. 8:999-1004 (2001).
14. H.-K. Nguyen, P. Lemieux, S. V. Vinogradov, C. L. Gebhart, N. Guerin, G. Paradis, T. K. Bronich, V. Y. Alakhov, and A. V. Kabanov. Evaluation of polyether-polyethylenimine graft copolymers as gene transfer agents. Gene Ther. 7:986-991 (2000).
15. I. Astafieva, I. Maksimova, E. Lukanidin, V. Alakhov, and A. Kabanov. Enhancement of the polycation-mediated uptake and cell transfection with Pluronic P85 block co-polymer. FEBS Lett. 389:278-280 (1996).
16. C. W. Cho, Y. S. Cho, H. K. Lee, Y. I. Yeom, S. N. Park, and D. Y. Yoon. Improvement of receptor-mediated gene delivery to HepG2 cells using an amphiphilic gelling agent. Biotechnol. Appl. Biochem. 32:21-26 (2000).
17. B. Jeong, Y. H. Bae, D. S. Lee, and S. W. Kim. Biodegradable block copolymers as injectable drug delivery systems. Nature 388: 860-862 (1997).
18. F. Liu, J. Yang, L. Huang, and D. Liu. Effect of non-ionic surfactants on the formation of DNA/emulsion complexes and emulsion-mediated gene transfer. Pharm. Res. 13:1642-1646 (1996).
19. J. Hartikka, L. Sukhu, C. Buchner, D. Hazard, V. Bozoukova, M. Margalith, W. K. Nishioka, C. J. Wheeler, M. Manthorp, and M. Sawdey. Electroporation- facilitated delivery of plasmid DNA in skeletal muscle: plasmid dependence of muscle damage and effect of poloxamer 188. Mol. Ther. 4:407-415 (2001).
20. M. Y. Kozlov, N. S. Melik-Nubarov, E. V. Batrakova, and A. V. Kabanov. Relationship between Pluronic block copolymer structure, critical micellization concentration and partitioning coefficients of low molecular mass solutes. Macromolecules 33:3305-3313 (2000).
21. A. V. Kabanov, P. Lemieux, S. Vinogradov, and V. Alakhov. Pluronic® block copolymers: novel functional molecules for gene therapy. Adv. Drug Del. Rev. 54:223-233 (2002).
22. V. Alakhov, E. Moskaleva, E. V. Batrakova, and A. V. Kabanov. Hypersensitization of multidrug resistant human ovarian carcinoma cells by Pluronic P85 block copolymer. Bioconjug. Chem. 7:209-216 (1995).
23. V. Alakhov and A. V. Kabanov. Block copolymeric biotransport carriers as versatile vehicles for drug delivery. Exp. Op. Invest. Drugs 7:1453-1473 (1998).
24. G. M. Zentner, R. Rathi, C. Shih, J. C. McRea, M.-H. Seo, H. Oh, B. G. Rhee, J. Mestecky, Z. Moldoveanu, M. Morgan, and S. Weitman. Biodegradable block copolymers for delivery of proteins and water-insoluble drugs. J. Control Release. 72:203-215 (2001).